Hydrophilic Agarose Macrobead Cultures Select for Outgrowth of Carcinoma Cell Populations That Can Restrict Tumor Growth
Smith B, Gazda L, Conn B, Jain K, Asina S, Levine D, Parker T, Laramore M, Martis P, Vinerean H, David E, Qiu S, North A, Couto C, Post G, Waters D, Cordon-Cardo C, Hall R, Gordon B, Diehl C, Stenzel K, Rubin A. Hydrophilic Agarose Macrobead Cultures Select for Outgrowth of Carcinoma Cell Populations That Can Restrict Tumor Growth. Cancer Research 2011, 71: 725-735. PMID: 21266362, DOI: 10.1158/0008-5472.can-10-2258.Peer-Reviewed Original ResearchConceptsTumor suppression functionStem cell nicheEpithelial-derived tumor cellsMouse cell modelNegative regulatory controlTumor-type specificStem cell-like subpopulationCarcinoma cell populationsCancer stem cellsCell nicheMolecular basisGrowth regulationTumor growth regulationGrowth controlTumor growthS phaseCell cycle accumulationSuppression functionStem cellsColony formationCancer cellsCell populationsRegulatory controlUnregulated proliferationCell model