Attenuation of genome-wide 5-methylcytosine level is an epigenetic feature of cutaneous malignant melanomas
Micevic G, Theodosakis N, Taube JM, Bosenberg MW, Rodi N. Attenuation of genome-wide 5-methylcytosine level is an epigenetic feature of cutaneous malignant melanomas. Melanoma Research 2017, 27: 85-96. PMID: 27997431, PMCID: PMC5812886, DOI: 10.1097/cmr.0000000000000315.Peer-Reviewed Original ResearchConceptsS-adenosyl methionineMelanoma cell linesEpigenetic featuresCell linesInactive chromatin regionsGenome-wide increaseUniversal methyl group donorMethyl group donorChromatin regionsCancer epigenomeEpigenetic modificationsEpigenetic abnormalitiesCytosine residuesMelanoma cell growthEpigenome modulationMalignant melanomaCell growthCovalent changesGroup donorSubcytotoxic levelsChemical substratesMelanoma cellsCutaneous malignant melanomaDose-dependent increaseResiduesHistone demethylase KDM5B is critical for PI3K‐AKT‐mTOR signaling and stemness of melanoma
Yan Q, Zhang S, Meeth K, Micevic G, Bosenberg M. Histone demethylase KDM5B is critical for PI3K‐AKT‐mTOR signaling and stemness of melanoma. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.468.1.Peer-Reviewed Original ResearchKnockdown of KDM5BHistone demethylase KDM5BMTOR signalingPI3K-AktImmune checkpoint blockadeEpigenetic stateMouse melanoma cellsCancer stem cellsMouse melanoma modelMPC populationKDM5BMelanoma formationCheckpoint blockadeTumor initiationStem cellsMelanoma modelMelanoma cellsCareer Development AwardKnockdownSignalingPilot grantsMelanoma