2024
Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm
Jiang Y, Luo C, Wang J, Palaniyappan L, Chang X, Xiang S, Zhang J, Duan M, Huang H, Gaser C, Nemoto K, Miura K, Hashimoto R, Westlye L, Richard G, Fernandez-Cabello S, Parker N, Andreassen O, Kircher T, Nenadić I, Stein F, Thomas-Odenthal F, Teutenberg L, Usemann P, Dannlowski U, Hahn T, Grotegerd D, Meinert S, Lencer R, Tang Y, Zhang T, Li C, Yue W, Zhang Y, Yu X, Zhou E, Lin C, Tsai S, Rodrigue A, Glahn D, Pearlson G, Blangero J, Karuk A, Pomarol-Clotet E, Salvador R, Fuentes-Claramonte P, Garcia-León M, Spalletta G, Piras F, Vecchio D, Banaj N, Cheng J, Liu Z, Yang J, Gonul A, Uslu O, Burhanoglu B, Uyar Demir A, Rootes-Murdy K, Calhoun V, Sim K, Green M, Quidé Y, Chung Y, Kim W, Sponheim S, Demro C, Ramsay I, Iasevoli F, de Bartolomeis A, Barone A, Ciccarelli M, Brunetti A, Cocozza S, Pontillo G, Tranfa M, Park M, Kirschner M, Georgiadis F, Kaiser S, Van Rheenen T, Rossell S, Hughes M, Woods W, Carruthers S, Sumner P, Ringin E, Spaniel F, Skoch A, Tomecek D, Homan P, Homan S, Omlor W, Cecere G, Nguyen D, Preda A, Thomopoulos S, Jahanshad N, Cui L, Yao D, Thompson P, Turner J, van Erp T, Cheng W, Feng J. Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm. Nature Communications 2024, 15: 5996. PMID: 39013848, PMCID: PMC11252381, DOI: 10.1038/s41467-024-50267-3.Peer-Reviewed Original ResearchConceptsGray matter changesDisorder constructsEnlarged striatumPsychiatric conditionsMental disordersSubcortical regionsSchizophreniaBiological foundationsMatter changesBrain imagingStriatumDisordersBiological factorsIndividualsSubtypesHealthy subjectsCross-sectional brain imagingHippocampusTemporal trajectoriesInternational cohortSubgroup 2Subgroup 1Subgroups
2023
Identifying psychosis subtypes use individualized covariance structural differential networks and multi-site clustering
Ji Y, Pearlson G, Bustillo J, Kochunov P, Turner J, Jiang R, Shao W, Zhang X, Fu Z, Li K, Liu Z, Xu X, Zhang D, Qi S, Calhoun V. Identifying psychosis subtypes use individualized covariance structural differential networks and multi-site clustering. Schizophrenia Research 2023, 264: 130-139. PMID: 38128344, DOI: 10.1016/j.schres.2023.12.013.Peer-Reviewed Original ResearchPsychosis subtypesSchizoaffective disorderBipolar disorderClinical phenotypeFirst-degree relativesTemporal-occipital cortexAmygdala-hippocampusClinical symptomsNeuroimaging featuresBipolar-Schizophrenia NetworkBrain alterationsHealthy controlsIntermediate Phenotypes (B-SNIP) consortiumOccipital cortexDecreased connectivitySubtypesStructural covarianceFractional amplitudeSubtype IILow-frequency fluctuationsNeurobiological heterogeneityGreater predispositionPsychosis spectrumGroup differencesDiagnostic classification
2017
965 Investigating Brain Structure Across Bipolar Disorder Subtypes: Findings from the Psychosis Affective Research Domain Intermediate Phenotypes (PARDIP) Study
Lutz O, Lizano P, Mothi S, Tandon N, Tamminga C, Clementz B, Sweeney J, Pearlson G, Keshavan M. 965 Investigating Brain Structure Across Bipolar Disorder Subtypes: Findings from the Psychosis Affective Research Domain Intermediate Phenotypes (PARDIP) Study. Biological Psychiatry 2017, 81: s390-s391. DOI: 10.1016/j.biopsych.2017.02.691.Peer-Reviewed Original Research