2024
Evidence from comprehensive independent validation studies for smooth pursuit dysfunction as a sensorimotor biomarker for psychosis
Meyhoefer I, Sprenger A, Derad D, Grotegerd D, Leenings R, Leehr E, Breuer F, Surmann M, Rolfes K, Arolt V, Romer G, Lappe M, Rehder J, Koutsouleris N, Borgwardt S, Schultze-Lutter F, Meisenzahl E, Kircher T, Keedy S, Bishop J, Ivleva E, McDowell J, Reilly J, Hill S, Pearlson G, Tamminga C, Keshavan M, Gershon E, Clementz B, Sweeney J, Hahn T, Dannlowski U, Lencer R. Evidence from comprehensive independent validation studies for smooth pursuit dysfunction as a sensorimotor biomarker for psychosis. Scientific Reports 2024, 14: 13859. PMID: 38879556, PMCID: PMC11180169, DOI: 10.1038/s41598-024-64487-6.Peer-Reviewed Original ResearchConceptsSmooth pursuit eye movementsPsychosis syndromePursuit eye movementsNon-psychotic bipolar disorderNon-psychotic affective disorderEye movementsSmooth pursuit dysfunctionMultivariate pattern analysisHealthy controlsPsychiatric sampleNeurobiological markersPsychosis probandsPsychotic syndromesAffective disordersPsychosis researchBipolar disorderPsychosis statusPsychosisSensorimotor functionSensorimotor measuresIndividual levelSensorimotor dysfunctionSensorimotorDisordersPattern analysis
2023
Peripheral inflammation is associated with impairments of inhibitory behavioral control and visual sensorimotor function in psychotic disorders
Zhang L, Lizano P, Xu Y, Rubin L, Lee A, Lencer R, Reilly J, Keefe R, Keedy S, Pearlson G, Clementz B, Keshavan M, Gershon E, Tamminga C, Sweeney J, Hill S, Bishop J. Peripheral inflammation is associated with impairments of inhibitory behavioral control and visual sensorimotor function in psychotic disorders. Schizophrenia Research 2023, 255: 69-78. PMID: 36965362, PMCID: PMC10175233, DOI: 10.1016/j.schres.2023.03.030.Peer-Reviewed Original ResearchConceptsCognitive domainsInhibitory controlGeneral cognitive abilitySpecific cognitive domainsInhibitory behavioral controlC-reactive proteinPsychotic disordersPsychosis spectrum disordersCognitive abilitiesPeripheral inflammationInflammation factorsSpectrum disorderSensorimotor functionSensorimotor tasksNeurobehavioral domainsGreater deficitsSubgroup of individualsBehavioral controlPsychosis subgroupsCognitive impairmentPreliminary evidenceHigher inflammation scoresNeurobehavioral batteryBrain anatomyBehavioral monitoring