2021
Anterior-posterior axis of hippocampal subfields across psychoses: A B-SNIP study
del Re E, Zeng V, Alliey-Rodriguez N, Lizano P, Bolo N, Lutz O, Pearlson G, Sweeney J, Clementz B, Gershon E, Tamminga C, Keshavan M. Anterior-posterior axis of hippocampal subfields across psychoses: A B-SNIP study. Biomarkers In Neuropsychiatry 2021, 5: 100037. DOI: 10.1016/j.bionps.2021.100037.Peer-Reviewed Original ResearchVolumetric abnormalitiesPsychosis probandsBipolar type 1Granule cell layerT MRI scansB-SNIP studyB-SNIPDentate gyrusBipolar-Schizophrenia NetworkHealthy controlsClinical dataHippocampal subfieldsDSM categoriesMRI scansSchizoaffective disorderHippocampusType 1Schizophrenia NetworkAbnormalitiesUnaffected relativesAnterior-posterior axisSchizophreniaPsychosisProbandsConclusions Differences
2017
Alzheimer disease brain atrophy subtypes are associated with cognition and rate of decline
Risacher S, Anderson W, Charil A, Castelluccio P, Shcherbinin S, Saykin A, Schwarz A, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Morris J, Shaw L, Khachaturian Z, Sorensen G, Carrillo M, Kuller L, Raichle M, Paul S, Davies P, Fillit H, Hefti F, Holtzman D, Mesulam M, Potter W, Snyder P, Schwartz A, Montine T, Petersen R, Aisen P, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Jiminez G, Balasubramanian A, Mason J, Sim I, Beckett L, Harvey D, Donohue M, Jack C, Bernstein M, Fox N, Thompson P, Schuff N, DeCArli C, Borowski B, Gunter J, Senjem M, Vemuri P, Jones D, Kantarci K, Ward C, Jagust W, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Landau S, Morris J, Cairns N, Householder E, Taylor-Reinwald L, Shaw L, Trojanowki J, Lee V, Korecka M, Figurski M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Faber K, Kim S, Nho K, Thal L, National N, Albert M, Frank R, Hsiao J, Kaye J, Quinn J, Silbert L, Lind B, Carter R, Dolen S, Schneider L, Pawluczyk S, Beccera M, Teodoro L, Spann B, Brewer J, Vanderswag H, Fleisher A, Heidebrink J, Lord J, Petersen R, Mason S, Albers C, Knopman D, Johnson K, Doody R, Villanueva-Meyer J, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Ances B, Morris J, Carroll M, Creech M, Franklin E, Mintun M, Schneider S, Oliver A, Marson D, Griffith R, Clark D, Geldmacher D, Brockington J, Roberson E, Love M, Grossman H, Mitsis E, Shah R, deToledo-Morrell L, Duara R, Varon D, Greig M, Roberts P, Albert M, Onyike C, D’Agostino D, Kielb S, Galvin J, Cerbone B, Michel C, Pogorelec D, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy M, Petrella J, Borges-Neto S, Wong T, Coleman E, Arnold S, Karlawish J, Wolk D, Clark C, Smith C, Jicha G, Hardy P, Sinha P, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, Mc-Adams-Ortiz C, Womack K, Mathews D, Quiceno M, Levey A, Lah J, Cellar J, Burns J, Swerdlow R, Brooks W, Apostolova L, Tingus K, Woo E, Silverman D, Lu P, Bartzokis G, Graff-Radford N, Parfitt F, Kendall T, Johnson H, Farlow M, Hake A, Matthews B, Brosch J, Herring S, Hunt C, van Dyck C, Carson R, MacAvoy M, Varma P, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Robin Hsiung G, Feldman H, Mudge B, Assaly M, Finger E, Pasternack S, Rachisky I, Trost D, Kertesz A, Bernick C, Munic D, Mesulam M, Lipowski K, Weintraub S, Bonakdarpour B, Kerwin D, Wu C, Johnson N, Sadowsky C, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Allard J, Lerner A, Ogrocki P, Tatsuoka C, Fatica P, Fletcher E, Maillard P, Olichney J, DeCarli C, Carmichael O, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Burke A, Trncic N, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Adeli A, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Flashman L, Seltzer M, Hynes M, Santulli R, Sink K, Gordineer L, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Perry D, Mintzer J, Spicer K, Bachman D, Finger E, Pasternak S, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Boles Ponto L, Shim H, Smith K, Relkin N, Chaing G, Lin M, Ravdin L, Smith A, Raj B, Fargher K. Alzheimer disease brain atrophy subtypes are associated with cognition and rate of decline. Neurology 2017, 89: 2176-2186. PMID: 29070667, PMCID: PMC5696639, DOI: 10.1212/wnl.0000000000004670.Peer-Reviewed Original ResearchConceptsMini-Mental State ExaminationDisease Assessment ScaleClinical declineAlzheimer's diseaseBaseline executive functionTau neuropathologyHippocampal volumeAD subtypesMRI scansAlzheimer's Disease Assessment ScaleClinical Dementia Rating SumF-fluorodeoxyglucose (FDG) PETBaseline clinical measuresFunctional Assessment QuestionnaireBaseline hippocampal volumeBaseline MRI scansAlzheimer's Disease Neuroimaging Initiative-1Amyloid-positive participantsVolumetric MRI scansExecutive functionAtrophy subtypesHippocampal atrophyClinical variablesCDR-SBADAS-Cog
2016
Morphometricity as a measure of the neuroanatomical signature of a trait
Sabuncu MR, Ge T, Holmes AJ, Smoller JW, Buckner RL, Fischl B, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Shaw L, Khachaturian Z, Sorensen G, Carrillo M, Kuller L, Raichle M, Paul S, Davies P, Fillit H, Hefti F, Holtzman D, Mesulam M, Potter W, Snyder P, Schwartz A, Green R, Montine T, Petersen R, Aisen P, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Jiminez G, Balasubramanian A, Mason J, Sim I, Beckett L, Harvey D, Donohue M, Jack C, Bernstein M, Fox N, Thompson P, Schuff N, DeCArli C, Borowski B, Gunter J, Senjem M, Vemuri P, Jones D, Kantarci K, Ward C, Jagust W, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Landau S, Morris J, Cairns N, Franklin E, Taylor-Reinwald L, Shaw L, Trojanowki J, Lee V, Korecka M, Figurski M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Faber K, Kim S, Nho K, Weiner M, Thal L, Thal L, Buckholtz N, Weiner M, Snyder P, Potter W, Paul S, Albert M, Frank R, Khachaturian Z, Hsiao J, Kaye J, Quinn J, Silbert L, Lind B, Carter R, Dolen S, Schneider L, Pawluczyk S, Becerra M, Teodoro L, Spann B, Brewer J, Vanderswag H, Fleisher A, Heidebrink J, Lord J, Petersen R, Mason S, Albers C, Knopman D, Johnson K, Doody R, Villanueva-Meyer J, Pavlik V, Shibley V, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Ances B, Morris J, Carroll M, Creech M, Franklin E, Mintun M, Schneider S, Oliver A, Marson D, Geldmacher D, Love M, Griffith R, Clark D, Brockington J, Roberson E, Grossman H, Mitsis E, Shah R, deToledo-Morrell L, Duara R, Greig-Custo M, Barker W, Albert M, Onyike C, D’Agostino D, Kielb S, Sadowski M, Sheikh M, Ulysse A, Gaikwad M, Doraiswamy P, Petrella J, Borges-Neto S, Wong T, Coleman E, Arnold S, Karlawish J, Wolk D, Clark C, Smith C, Jicha G, Hardy P, Sinha P, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Potkin S, Preda A, Nguyen D, Womack K, Mathews D, Quiceno M, Levey A, Lah J, Cellar J, Burns J, Swerdlow R, Brooks W, Apostolova L, Tingus K, Woo E, Silverman D, Lu P, Bartzokis G, Graff-Radford N, Parfitt F, Poki-Walker K, Farlow M, Hake A, Matthews B, Brosch J, Herring S, van Dyck C, Carson R, MacAvoy M, Varma P, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Mudge B, Sossi V, Feldman H, Assaly M, Finger E, Pasternack S, Rachisky I, Trost D, Kertesz A, Bernick C, Munic D, Mesulam M, Rogalski E, Lipowski K, Weintraub S, Bonakdarpour B, Kerwin D, Wu C, Johnson N, Sadowsky C, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Allard J, Lerner A, Ogrocki P, Tatsuoka C, Fatica P, Fletcher E, Maillard P, Olichney J, DeCarli C, Carmichael O, Kittur S, Borrie M, Lee T, Bartha D, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Burke A, Milliken A, Trncic N, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Kelley B, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Flashman L, Seltzer M, Hynes M, Santulli R, Sink K, Gordineer L, Williamson J, Garg P, Watkins F, Ott B, Tremont G, Daiello L, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Perry D, Mintzer J, Spicer K, Bachman D, Finger E, Pasternak S, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Smith K, Koleva H, Nam K, Shim H, Relkin N, Chiang G, Lin M, Ravdin L, Smith A, Raj B, Fargher K, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Green R, Harvey D, Jack C, Jagust W, Morris J, Saykin A, Shaw L, Toga A, Trojanowki J, Neylan T, Grafman J, Green R, Montine T, Weiner M, Petersen R, Aisen P, Thomas R, Donohue M, Gessert D, Sather T, Davis M, Morrison R, Jiminez G, Neylan T, Hayes J, Finley S, Harvey D, Donohue M, Jack C, Bernstein M, Borowski B, Gunter J, Senjem M, Kantarci K, Ward C, Jagust W, Koeppe R, Foster N, Reiman E, Chen K, Landau S, Morris J, Cairns N, Householder E, Shaw L, Trojanowki J, Lee V, Korecka M, Figurski M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Faber K, Kim S, Nho K, Weiner M, Friedl K, Schneider L, Pawluczyk S, Becerra M, Brewer J, Vanderswag H, Stern Y, Honig L, Bell K, Fleischman D, Arfanakis K, Shah R, Duara R, Varon D, Greig M, Doraiswamy P, Petrella J, James O, Porsteinsson A, Goldstein B, Martin K, Potkin S, Preda A, Nguyen D, Mintzer J, Massoglia D, Brawman-Mintzer O, Sadowsky C, Martinez W, Villena T, Jagust W, Landau S, Rosen H, Perry D, Turner R, Behan K, Reynolds B, Sperling R, Johnson K, Marshall G, Sabbagh M, Jacobson S, Sirrel S, Obisesan T, Wolday S, Allard J, Johnson S, Fruehling J, Harding S, Peskind E, Petrie E, Li G, Yesavage J, Taylor J, Furst A, Chao S, Relkin N, Chiang G, Ravdin L. Morphometricity as a measure of the neuroanatomical signature of a trait. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: e5749-e5756. PMID: 27613854, PMCID: PMC5047166, DOI: 10.1073/pnas.1604378113.Peer-Reviewed Original Research
2014
Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia
Meda SA, Ruaño G, Windemuth A, O’Neil K, Berwise C, Dunn SM, Boccaccio LE, Narayanan B, Kocherla M, Sprooten E, Keshavan MS, Tamminga CA, Sweeney JA, Clementz BA, Calhoun VD, Pearlson GD. Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: e2066-e2075. PMID: 24778245, PMCID: PMC4024891, DOI: 10.1073/pnas.1313093111.Peer-Reviewed Original ResearchConceptsDefault mode networkPsychotic bipolar disorderUnaffected first-degree relativesFirst-degree relativesSZ probandsResting-state functional MRI scansBipolar disorderMode networkFunctional MRI scansLong-term potentiationBrain's default mode networkGlobal enrichment analysisSubset of controlsPatient groupHealthy controlsDMN modulationDrug treatmentImmune responsePsychiatric disordersStudy subjectsMRI scansDMN connectivityMultivariate analysisFunctional connectivitySchizophrenia
2009
Subregional neuroanatomical change as a biomarker for Alzheimer's disease
Holland D, Brewer J, Hagler D, Fennema-Notestine C, Dale A, Weiner M, Thal L, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Gamst A, Potter W, Montine T, Anders D, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, Bandy D, Koeppe R, Foster N, Reiman E, Chen K, Shaw L, Lee V, Korecka M, Crawford K, Neu S, Harvey D, Kornak J, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Vorobik R, Quinn J, Schneider L, Pawluczyk S, Spann B, Fleisher A, Vanderswag H, Heidebrink J, Lord J, Johnson K, Doody R, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig L, Bell K, Morris J, Mintun M, Schneider S, Marson D, Griffith R, Badger B, Grossman H, Tang C, Stern J, deToledo-Morrell L, Shah R, Bach J, Duara R, Isaacson R, Strauman S, Albert M, Pedroso J, Toroney J, Rusinek H, de Leon M, De Santi S, Doraiswamy P, Petrella J, Aiello M, Clark C, Pham C, Nunez J, Smith C, Given C, Hardy P, DeKosky S, Oakley M, Simpson D, Ismail M, Porsteinsson A, McCallum C, Cramer S, Mulnard R, McAdams-Ortiz C, Diaz-Arrastia R, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Laubinger M, Bartzokis G, Silverman D, Lu P, Fletcher R, Parfitt F, Johnson H, Farlow M, Herring S, Hake A, van Dyck C, MacAvoy M, Bifano L, Chertkow H, Bergman H, Hosein C, Black S, Graham S, Caldwell C, Feldman H, Assaly M, Hsiung G, Kertesz A, Rogers J, Trost D, Bernick C, Gitelman D, Johnson N, Mesulam M, Sadowsky C, Villena T, Mesner S, Aisen P, Johnson K, Behan K, Sperling R, Rentz D, Johnson K, Rosen A, Tinklenberg J, Ashford W, Sabbagh M, Connor D, Obradov S, Killiany R, Norbash A, Obisesan T, Jayam-Trouth A, Wang P, Auchus A, Huang J, Friedland R, DeCarli C, Fletcher E, Carmichael O, Kittur S, Mirje S, Johnson S, Borrie M, Lee T, Asthana S, Carlsson C, Potkin S, Highum D, Preda A, Nguyen D, Tariot P, Hendin B, Scharre D, Kataki M, Beversdorf D, Zimmerman E, Celmins D, Brown A, Gandy S, Marenberg M, Rovner B, Pearlson G, Blank K, Anderson K, Saykin A, Santulli R, Pare N, Williamson J, Sink K, Potter H, Raj B, Giordano A, Ott B, Wu C, Cohen R, Wilks K, Safirstein B. Subregional neuroanatomical change as a biomarker for Alzheimer's disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 20954-20959. PMID: 19996185, PMCID: PMC2791580, DOI: 10.1073/pnas.0906053106.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentAlzheimer's diseaseClinical trialsOutcome measuresCerebral volume changesDisease-modifying effectsCerebral structural changesDisease-modifying agentsSerial MRI scansTemporal lobe cortical regionsSensitive outcome measuresDisease-related changesBrain atrophyNeuroprotective effectsAD pathologyHealthy controlsSubregional atrophyCortical changesEarly diagnosisNeuroanatomical changesCortical thicknessNormal subjectsMRI scansVentricular volumeClinical practice
2000
MRI findings differentiate between late‐onset schizophrenia and late‐life mood disorder
Rabins P, Aylward E, Holroyd S, Pearlson G. MRI findings differentiate between late‐onset schizophrenia and late‐life mood disorder. International Journal Of Geriatric Psychiatry 2000, 15: 954-960. PMID: 11044878, DOI: 10.1002/1099-1166(200010)15:10<954::aid-gps224>3.0.co;2-o.Peer-Reviewed Original ResearchConceptsLate-onset schizophreniaLate-life bipolar disorderBilateral cortical atrophyLarger third ventriclesRight temporal hornLate-life mood disordersLate-life depressionDegree of atrophyNormal control groupGender-matched controlsFunctional imaging studiesSulcal enlargementCortical atrophyMRI findingsTemporal hornFunctional abnormalitiesSylvian fissureMood disordersThird ventricleOutpatient servicesMRI scansPatientsAffective disordersControl groupBipolar disorderMeasurement of the planum temporale (PT) on magnetic resonance imaging scans: temporal PT alone and with parietal extension
Honeycutt N, Musick A, Barta P, Pearlson G. Measurement of the planum temporale (PT) on magnetic resonance imaging scans: temporal PT alone and with parietal extension. Psychiatry Research 2000, 98: 103-116. PMID: 10762736, DOI: 10.1016/s0925-4927(00)00043-3.Peer-Reviewed Original Research
1997
Measurement of frontal lobe volume on magnetic resonance imaging scans
Aylward E, Augustine A, Li Q, Barta P, Pearlson G. Measurement of frontal lobe volume on magnetic resonance imaging scans. Psychiatry Research 1997, 75: 23-30. PMID: 9287371, DOI: 10.1016/s0925-4927(97)00026-7.Peer-Reviewed Original Research