2018
P1‐047: COGNITIVE BEHAVIORAL THERAPY TO ENHANCE MEMORY TRAINING EFFICACY IN PEOPLE WITH DEMENTIA: 1‐YEAR FOLLOW‐UP
Teti A, Fiszdon J, Taylor B, Twamley E, Pearlson G, Choi J. P1‐047: COGNITIVE BEHAVIORAL THERAPY TO ENHANCE MEMORY TRAINING EFFICACY IN PEOPLE WITH DEMENTIA: 1‐YEAR FOLLOW‐UP. Alzheimer's & Dementia 2018, 14: p285-p285. DOI: 10.1016/j.jalz.2018.06.048.Peer-Reviewed Original Research
2017
APOE genotype and early &bgr;-amyloid accumulation in older adults without dementia
Lim Y, Mormino E, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Liu E, Green R, Montine T, Petersen R, Aisen P, Gamst A, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Beckett L, Harvey D, Gamst A, Donohue M, Kornak J, Jack C, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Jagust W, Bandy D, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Morris J, Cairns N, Taylor-Reinwald L, Trojanowki J, Shaw L, Lee V, Korecka M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Dolen S, Schneider L, Pawluczyk S, Spann B, Brewer J, Vanderswag H, Heidebrink J, Lord J, Petersen R, Johnson K, Doody R, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig L, Bell K, Morris J, Ances B, Carroll M, Leon S, Mintun M, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah R, Duara R, Varon D, Roberts P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Coleman R, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, McAdams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Lu P, Bartzokis G, Silverman D, Graff-Radford, MBBCH N, Parfitt F, Johnson H, Farlow M, Hake A, Matthews B, Herring S, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Robin Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Bwayo S, Lerner A, Hudson L, Ogrocki P, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha D, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Saykin A, Santulli R, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Longmire C, Spicer K, Finger E, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Boles Ponto L, Shim H, Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Raj B. APOE genotype and early &bgr;-amyloid accumulation in older adults without dementia. Neurology 2017, 89: 1028-1034. PMID: 28794245, PMCID: PMC5589795, DOI: 10.1212/wnl.0000000000004336.Peer-Reviewed Original ResearchConceptsLongitudinal Aβ accumulationAβ accumulationAβ groupOlder ageOlder adultsPrimary prevention trialsΒ-amyloid accumulationInfluence of agePrevention trialsAmyloid accumulationΕ4 carriageFlorbetapir PETΕ4 alleleHigh riskChronologic ageLongitudinal accumulationAbnormal levelsLongitudinal rateDementiaLinear mixed modelsAgeHigh rateΕ4AβAdults
2012
Hexanucleotide repeat expansions in C9ORF72 in the spectrum of motor neuron diseases
van Rheenen W, van Blitterswijk M, Huisman M, Vlam L, van Doormaal P, Seelen M, Medic J, Dooijes D, de Visser M, van der Kooi A, Raaphorst J, Schelhaas H, van der Pol W, Veldink J, van den Berg L, Weiner M, Aisen P, Petersen R, Clifford R, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Liu E, Montine T, Gamst A, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Beckett L, Harvey D, Gamst A, Donohue M, Kornak J, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Bandy D, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Cairns N, Taylor-Reinwald L, Shaw L, Lee V, Korecka M, Crawford K, Neu S, Foroud T, Potkin S, Shen L, Kachaturian Z, Frank R, Snyder P, Kaye J, Dolen S, Quinn J, Schneider L, Pawluczyk S, Spann B, Brewer J, Vanderswag H, Heidebrink J, Lord J, Petersen R, Johnson K, S. Doody R, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig L, Bell K, Morris J, Mintun M, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah R, Duara R, Varon D, Roberts P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon M, Glodzik L, Doraiswamy P, Petrella J, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Lopez O, Oakley M, Simpson D, Ismail M, Brand C, Mulnard R, Thai G, Mc-Adams-Ortiz C, Diaz-Arrastia R, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Bartzokis G, Silverman D, Lu P, Apostolova L, Graff-Radford N, Parfitt F, Johnson H, Farlow M, Herring S, Hake A, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Feldman H, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Wu C, Johnson N, Mesulam M, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Frey M, Johnson K, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Killiany R, Norbash A, Obisesan T, Wolday S, Bwayo S, Lerner A, Hudson L, Ogrocki P, DeCarli C, Fletcher E, Carmichael O, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Hendin B, Scharre D, Kataki M, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Saykin A, Santulli R, Schwartz E, Williamson J, Sink K, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Longmire C, Spicer K, Kwon S, Kim J, Cho K, Shin D, Ko Y, Lee S, Cha J, Kim Y, Shin D, Jang H, Choi N, Hong S, Rha J, Hong K, Kim E, Choi J, Sohn S, Shin W, HyukHeo S, Chung K, Park J, Lee J, Park J, Park T, Bae H, Han M, Kwon H, Lee K, Lee T, Jeong D, Lee J, Ashwal S, deVeber G, Ferriero D, Fullerton H, Ichord R, Kirkham F, Lynch J, O'Callaghan F, Pavlakis S, Sebire G, Willan A, Willan A, Sofronas M, Dlamini N, Elbers J, Nowak-Göttl U, Düring C, Krümpel A, Plumb P, Journeycake J, van de Bruinhorst K, Gossett D, Hernandez Chavez M, Monagle P, MacKay M, Barnes C, Furmedge J, Gordon A, Benedict S, Bale J, Nielson D, Abdalla A, Chadehumbe M, Kabbouche M, Karti P, Phillips T, Friedman N, Rizkallah E, Zamel K, Wiznitzer M, Lidsky K, Bernard T, Goldenberg N, Armstrong-Wells J, Booth F, Nash M, Beslow L, Carpenter J, Chang T, Weinstein S, Kan L, Smith R, Maytal J, Sy-Kho R, Yager J, Massicotte P, Ashwal S, McClure C, Bjornson B, Hukin J, Bucevska M, Kent S, Riviello J, Rivkin M, Trenor C, Amlie-Lefond C, Whelan H, Ferriero D, Fullerton H, Fox C, Pavlakis S, Goodman S, Levinson K, Kolk A, Laugesaar R, Talvik T, Imam H, Thomas T, Golomb M, Kirton A, Heyer G, Ganesan V, Saengpattrachai M, Crosswell H, Mancuso A, Tatishvili N, Yeh A, Humpherys P, Abraham L, Alveal L, Ortiz M, Altuna D, Maxit C, Gonzalez V, Alam M, Buckley D, Penney S, Jordan L, Grabowski E, Chan A, Deray M, Khatib Z, Kovacevic G, Kosofsky B, Leifer D, Nass R, Wong V, Catsman C, El-Hakam L, Sebire G, Cholette J, Narang S, Lerner N, Carpenter S, Bischoff K, Frei-Jones M, Masur D, Epstein L, Bagiella E, Hinton V, Gallentine W, Rende E, Provenzale J, Voyvodic J, Song A, Conklin T, O'Hara K, Seinfeld S, Conry J, Glauser T, Ayala J, Facchini R, Sigalova M, Hannigan J, Weiss E, Mancini A, Curran J, Ahlm S, Renaldi J, Umanzour D, Kim A, Hamidullah A, Litherland C, Bonner M, Xu Y, Van de Water V, Grasso S, Kushner D, Culbert J, Bush B, Chandrasekaran S, Davis L, Rogers C, Sabo C, Wang H, Noebels J. Hexanucleotide repeat expansions in C9ORF72 in the spectrum of motor neuron diseases. Neurology 2012, 79: 878-882. PMID: 22843265, DOI: 10.1212/wnl.0b013e3182661d14.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAgedAged, 80 and overAmyotrophic Lateral SclerosisC9orf72 ProteinCohort StudiesConfidence IntervalsDementiaDNADNA Repeat ExpansionFemaleFrontotemporal Lobar DegenerationGenotypeHumansMaleMiddle AgedMotor Neuron DiseaseMuscular Atrophy, SpinalMutationParkinson DiseasePolymerase Chain ReactionProportional Hazards ModelsProteinsSurvivalYoung AdultConceptsProgressive muscular atrophyPrimary lateral sclerosisAmyotrophic lateral sclerosisSporadic amyotrophic lateral sclerosisParkinson's diseaseShorter survivalLateral sclerosisRelatives of patientsFamilial aggregationRepeat expansionHexanucleotide repeat expansionControl subjectsMotor neuronsLarge cohortPatientsMuscular atrophyGenetic testingEarly onsetMajor causeDementiaC9orf72SclerosisFALSEarly ageDutch descent
1994
Altered cortical blood flow in HIV-seropositive individuals with and without dementia
Harris G, Pearlson G, McArthur J, Zeger S, LaFrance N. Altered cortical blood flow in HIV-seropositive individuals with and without dementia. AIDS 1994, 8: 495-500. PMID: 8011253, DOI: 10.1097/00002030-199404000-00012.Peer-Reviewed Original ResearchConceptsHIV-1-infected groupHIV-1-infected individualsNormal controlsBlood flowHIV-1-seropositive individualsRegional cerebral blood flowCortical profilesCerebral cortical perfusionCortical perfusion changesHIV-seropositive individualsCerebral perfusion abnormalitiesCortical blood flowCerebral blood flowSingle photon emissionTomographic imaging studiesHigh-frequency powerCortical perfusionCerebral cortexPerfusion abnormalitiesPerfusion changesSevere dementiaImaging studiesDistribution of radiotracerPhoton emissionDementiaComputed Tomography
Burns A, Pearlson G. Computed Tomography. 1994, 407-426. DOI: 10.1007/978-1-4615-6805-6_23.Peer-Reviewed Original ResearchComputed tomographyCerebral angiographyCerebrovascular accidentHead injuryNon-invasive methodBrain damageIntracerebral lesionsBrain tumorsFirst non-invasive methodClinical practiceClinical neuroscienceIntracranial structuresDementiaTomographyAngiographyInjuryLesionsPneumoencephalographyTumorsDiagnosis
1991
Centrum semiovale white matter CT changes associated with normal ageing, Alzheimer's disease and late life depression with and without reversible dementia
Pearlson G, Rabins P, Burns A. Centrum semiovale white matter CT changes associated with normal ageing, Alzheimer's disease and late life depression with and without reversible dementia. Psychological Medicine 1991, 21: 321-328. PMID: 1876637, DOI: 10.1017/s0033291700020420.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseCT attenuation numbersGray matterAttenuation numberCranial CT scanLate-life depressionElderly patientsReversible dementiaPatient groupCT changesLife depressionMajor depressionCentrum semiovaleAttenuation valuesCT scanNormal controlsElderly controlsNeuropsychological evaluationNormal agingDiseasePatientsDepressionCognitive tasksDementiaReliable meansSuprasellar cistern measures as a reflection of dementia in Alzheimer's disease but not Huntington's disease
Aylward E, Karagiozis H, Pearlson G, Folstein M. Suprasellar cistern measures as a reflection of dementia in Alzheimer's disease but not Huntington's disease. Journal Of Psychiatric Research 1991, 25: 31-47. PMID: 1827501, DOI: 10.1016/0022-3956(91)90014-2.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseSuprasellar cisternDisease patientsAD patientsTemporal lobeCognitive statusHuntington's diseaseRespective age-matched controlsBasal forebrain areasAge-matched controlsHuntington's disease patientsForebrain areasEntorhinal cortexCognitive declinePatientsDiseaseBrain widthLobeHDStatusAtrophyDementiaPerceptual ratingsCortex
1990
Confrontation naming deficit in dementia of depression
Speedie L, Rabins P, Pearlson G, Moberg P. Confrontation naming deficit in dementia of depression. Journal Of Neuropsychiatry 1990, 2: 59-63. PMID: 2136062, DOI: 10.1176/jnp.2.1.59.Peer-Reviewed Original ResearchConceptsDementia of depressionDelayed visual memoryIrreversible dementiaMemory taskVisual memoryFree recallLanguage abilityNondepressed control subjectsDepressed patientsMemoryCognitive impairmentNormal cognitionElderly depressed patientsRecallDepressionTaskDementiaMajor depressionReversible dementiaPatient groupControl subjectsCognitionPatientsDeficitsConfrontation
1988
SPECT IMAGING WITH I-123 ISOPROPYL AMPHETAMINE IN ASYMPTOMATIC HIV SEROPOSITIVE PERSONS
LaFrance N, Pearlson G, Schaerf F, McArthur J, Bascom M, Kumar A, Turek J, Cole P, Chen J, Wagner H. SPECT IMAGING WITH I-123 ISOPROPYL AMPHETAMINE IN ASYMPTOMATIC HIV SEROPOSITIVE PERSONS. Clinical Nuclear Medicine 1988, 13: 393. DOI: 10.1097/00003072-198805000-00042.Peer-Reviewed Original ResearchHIV encephalopathyAsymptomatic HIV-seropositive personsMini-Mental State EvaluationHIV-seropositive personsForamen of MonroSeropositive personsSeropositive individualsBasal gangliaFirst manifestationEarly predictorNormal controlsPatientsSubcortical regionsPET studiesIsopropyl amphetamineSPECT imagingCortical asymmetryAsymmetry indexSPECT slicesTrails BSingle studyDementiaAIDSSPECT dataMonths
1987
Olfactory Recognition: Differential Impairments in Early and Late Huntington's and Alzheimer's Diseases
Moberg P, Pearlson G, Speedie L, Lipsey J, Strauss M, Folstein S. Olfactory Recognition: Differential Impairments in Early and Late Huntington's and Alzheimer's Diseases. Journal Of Clinical And Experimental Neuropsychology 1987, 9: 650-664. PMID: 2961789, DOI: 10.1080/01688638708405208.Peer-Reviewed Original ResearchConceptsHuntington's diseaseOverall patient groupOlfactory brain regionsPatient groupAlzheimer groupSenile dementiaAlzheimer typeNormal controlsDisease processPatientsAlzheimer's diseaseBrain regionsCognitive deficitsHuntington's patientsGlobal impairmentDiseaseOlfactory discriminationOlfactory paradigmVisual performanceDifferential impairmentImpairmentDeficitsGroupOlfactory recognitionDementia
1986
Normal Aging, Alzheimer's Disease, and Senile Dementia: Aspects on Etiology, Pathogenesis, Diagnosis and Treatment
PEARLSON G. Normal Aging, Alzheimer's Disease, and Senile Dementia: Aspects on Etiology, Pathogenesis, Diagnosis and Treatment. American Journal Of Psychiatry 1986, 143: 1302-1302. DOI: 10.1176/ajp.143.10.1302.Peer-Reviewed Original ResearchCerebral ventricular size and cerebrospinal fluid acetylcholinesterase levels in senile dementia of the Alzheimer type
Pearlson G, Tune L. Cerebral ventricular size and cerebrospinal fluid acetylcholinesterase levels in senile dementia of the Alzheimer type. Psychiatry Research 1986, 17: 23-29. PMID: 3484831, DOI: 10.1016/0165-1781(86)90038-7.Peer-Reviewed Original ResearchConceptsVentricle-brain ratioMini-Mental State ExaminationSenile dementiaComputed tomographyAlzheimer typeCerebrospinal fluid acetylcholinesterase activityLateral ventricle-brain ratiosCerebral ventricular sizeDuration of illnessAChE activityCSF AChE activityDegree of dementiaCerebral atrophyVentricular sizeCT scanDilutional effectState ExaminationCognitive impairmentAcetylcholinesterase levelsRadioenzymatic assayDementiaAcetylcholinesterase activityLaboratory dataPatientsSignificant correlation