Synergistic Anti-Tumor Efficacy of BET Inhibitors JQ1 and Otx-015 in Combination with Dasatinib in Preclinical Models of T-Cell Lymphomas
Rizzitano S, Cavanè A, Piazzoni M, Vendramin A, Gimondi S, Biancon G, Malan S, Dodero A, Corradini P, Carniti C. Synergistic Anti-Tumor Efficacy of BET Inhibitors JQ1 and Otx-015 in Combination with Dasatinib in Preclinical Models of T-Cell Lymphomas. Blood 2016, 128: 3967. DOI: 10.1182/blood.v128.22.3967.3967.Peer-Reviewed Original ResearchPeripheral T-cell lymphomaT-cell lymphomaT cell receptorChou-Talalay combination indexDose-dependent mannerCell cycle distributionFlow cytometryCell cycle arrestC-myc expressionPreclinical modelsTK inhibitorsCell linesLeukemia cell linesInhibitor dasatinibC-MycWestern blottingG1 populationGene expression profilingSynergistic anti-tumor effectBET inhibitorsLong-term remissionG0/G1 phase arrestStem cell transplantationSynergistic anti-tumor efficacyMitochondrial depolarizationCirculating miRNA panel for prediction of acute graft-versus-host disease in lymphoma patients undergoing matched unrelated hematopoietic stem cell transplantation
Gimondi S, Dugo M, Vendramin A, Bermema A, Biancon G, Cavané A, Corradini P, Carniti C. Circulating miRNA panel for prediction of acute graft-versus-host disease in lymphoma patients undergoing matched unrelated hematopoietic stem cell transplantation. Experimental Hematology 2016, 44: 624-634.e1. PMID: 27013207, DOI: 10.1016/j.exphem.2016.03.005.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBiomarkersCluster AnalysisCombined Modality TherapyFemaleGene ExpressionGene Expression ProfilingGene Regulatory NetworksGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansLymphomaMaleMicroRNAsMiddle AgedPrognosisReproducibility of ResultsTime FactorsTransplantation, HomologousYoung AdultConceptsAllo-HSCTLymphoma patientsReal-time polymerase chain reactionAcute graftPolymerase chain reactionAllogeneic hematopoietic stem cell transplantationUnrelated hematopoietic stem cellHematopoietic stem cell transplantationHost disease (GVHD) resultsNon-aGVHD patientsStem cell transplantationChain reactionQuantitative real-time polymerase chain reactionRoutine clinical useCutaneous GVHDIntestinal GVHDHost diseaseSignificant morbidityUnrelated donorsCell transplantationPredictive biomarkersMicroRNA expression profileBlood samplingTherapeutic strategiesPatients