2023
Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions
McIntyre R, Alsuwaidan M, Baune B, Berk M, Demyttenaere K, Goldberg J, Gorwood P, Ho R, Kasper S, Kennedy S, Ly-Uson J, Mansur R, McAllister-Williams R, Murrough J, Nemeroff C, Nierenberg A, Rosenblat J, Sanacora G, Schatzberg A, Shelton R, Stahl S, Trivedi M, Vieta E, Vinberg M, Williams N, Young A, Maj M. Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions. World Psychiatry 2023, 22: 394-412. PMID: 37713549, PMCID: PMC10503923, DOI: 10.1002/wps.21120.Peer-Reviewed Original ResearchTreatment-resistant depressionTranscranial magnetic stimulationEuropean Medicines AgencyIntravenous ketamineManagement of TRDRepetitive transcranial magnetic stimulationOlanzapine-fluoxetine combinationSecond-generation antipsychoticsSignificant symptomatic reliefManual-based psychotherapiesSerious public health implicationsTheta-burst transcranial magnetic stimulationQuality of carePublic health implicationsIntranasal esketaminePartial respondersAdjunctive treatmentElectroconvulsive therapySymptomatic reliefConventional antidepressantsMedication switchingAntidepressant trialsRisk factorsInvestigational interventionMagnetic stimulation
2000
A randomized clinical trial of repetitive transcranial magnetic stimulation in the treatment of major depression
Berman R, Narasimhan M, Sanacora G, Miano A, Hoffman R, Hu X, Charney D, Boutros N. A randomized clinical trial of repetitive transcranial magnetic stimulation in the treatment of major depression. Biological Psychiatry 2000, 47: 332-337. PMID: 10686268, DOI: 10.1016/s0006-3223(99)00243-7.Peer-Reviewed Original ResearchConceptsRepetitive transcranial magnetic stimulationTranscranial magnetic stimulationMajor depressionHDRS scoresMagnetic stimulationEfficacy of rTMSHamilton Depression Rating Scale scoresActive repetitive transcranial magnetic stimulationRandomized double-blind mannerTreatment-resistant major depressionDepression Rating Scale scoresDouble-blind mannerTreatment-resistant patientsRandomized clinical trialsRating Scale scoresMotor threshold determinationActive treatmentSham treatmentTreatment trialsClinical trialsTreatment resistanceMean decreaseDepressive symptomsControl groupScale score