1996
Time course of the defective α-cell response to hypoglycemia in diabetic BB rats
Jacob R, Dziura J, Morgen J, Shulman G, Sherwin R. Time course of the defective α-cell response to hypoglycemia in diabetic BB rats. Metabolism 1996, 45: 1422-1426. PMID: 8931649, DOI: 10.1016/s0026-0495(96)90125-0.Peer-Reviewed Original ResearchConceptsInsulin-dependent diabetes mellitusDays of diabetesBB ratsBB/Wor ratsNondiabetic BB ratsΑ-cell responseDiabetic BB ratsCourse of diabetesPancreatic glucagon levelsPancreatic glucagon contentBeta-cell functionPancreatic insulin contentHypoglycemic challengeCounterregulatory responsesDiabetes onsetDiabetes mellitusGlucagon levelsGlucagon releasePlasma glucagonGlucagon concentrationsInsulin clampGlucagon contentBaseline plasmaDisease onsetGroup 2
1992
Simultaneous Insulinlike Growth Factor I and Insulin Resistance in Obese Zucker Rats
Jacob R, Sherwin R, Greenawalt K, Shulman G. Simultaneous Insulinlike Growth Factor I and Insulin Resistance in Obese Zucker Rats. Diabetes 1992, 41: 691-697. PMID: 1587396, DOI: 10.2337/diab.41.6.691.Peer-Reviewed Original ResearchConceptsInsulinlike growth factor IGrowth factor IObese Zucker ratsObese ratsLean ratsZucker ratsChain amino acid concentrationsFactor IGlucose uptakeIGF-I infusionDiabetic BB ratsIGF-I levelsEffects of IGFEuglycemic insulin clampLean control ratsObese groupBB ratsInsulin clampInsulin resistanceLean controlsControl ratsRats 6Amino acid concentrationsVivo effectsIGF
1991
The effect of CP 68,722, a thiozolidinedione derivative, on insulin sensitivity in lean and obese Zucker rats
Bowen L, Stein P, Stevenson R, Shulman G. The effect of CP 68,722, a thiozolidinedione derivative, on insulin sensitivity in lean and obese Zucker rats. Metabolism 1991, 40: 1025-1030. PMID: 1943727, DOI: 10.1016/0026-0495(91)90124-f.Peer-Reviewed Original ResearchConceptsHepatic glucose productionInsulin-induced suppressionObese animalsObese Zucker ratsGlucose disposalInsulin sensitivityDrug treatmentFree fatty acidsZucker ratsHigher insulin infusion ratesEuglycemic hyperinsulinemic clamp techniqueInsulin-resistant animal modelsPeripheral glucose disposalHyperinsulinemic clamp techniquePeripheral glucose uptakeInsulin infusion rateInsulin clampInsulin suppressionKetone levelsInfusion rateAnimal modelsClamp techniqueEffect of CPLean animalsLipid metabolism