2008
N-acylphosphatidylethanolamine, a Gut- Derived Circulating Factor Induced by Fat Ingestion, Inhibits Food Intake
Gillum MP, Zhang D, Zhang XM, Erion DM, Jamison RA, Choi C, Dong J, Shanabrough M, Duenas HR, Frederick DW, Hsiao JJ, Horvath TL, Lo CM, Tso P, Cline GW, Shulman GI. N-acylphosphatidylethanolamine, a Gut- Derived Circulating Factor Induced by Fat Ingestion, Inhibits Food Intake. Cell 2008, 135: 813-824. PMID: 19041747, PMCID: PMC2643061, DOI: 10.1016/j.cell.2008.10.043.Peer-Reviewed Original ResearchConceptsFood intakeInhibits food intakeTreatment of obesityNovel therapeutic targetCentral nervous systemUnknown physiological significanceFat ingestionCirculating factorsN-acylphosphatidylethanolaminePlasma lipidsIntracerebroventricular infusionPhysiologic dosesSystemic administrationTherapeutic targetBody weightNervous systemIngested fatSmall intestineIntakeTaste aversionInfusionPhysiological significanceNanomolar amountsObesityHypothalamus
1995
Local Ventromedial Hypothalamus Glucopenia Triggers Counterregulatory Hormone Release
Borg W, Sherwin R, During M, Borg M, Shulman G. Local Ventromedial Hypothalamus Glucopenia Triggers Counterregulatory Hormone Release. Diabetes 1995, 44: 180-184. PMID: 7859938, DOI: 10.2337/diab.44.2.180.Peer-Reviewed Original ResearchConceptsVentromedial hypothalamusFrontal lobeMicrodialysis probeCounterregulatory hormone releaseCellular glucopeniaCounterregulatory hormonesCounterregulatory responsesPlasma glucagonPlasma glucoseLocal perfusionHormone releaseCerebral tissueStriking elevationControl groupGlucopeniaBrain tissueGlucopenic agentHypoglycemiaRatsTwofold increaseLobeTissueNorepinephrineHypothalamusEpinephrine