2007
Prevention of nosocomial transmission of extensively drug-resistant tuberculosis in rural South African district hospitals: an epidemiological modelling study
Basu S, Andrews JR, Poolman EM, Gandhi NR, Shah NS, Moll A, Moodley P, Galvani AP, Friedland GH. Prevention of nosocomial transmission of extensively drug-resistant tuberculosis in rural South African district hospitals: an epidemiological modelling study. The Lancet 2007, 370: 1500-1507. PMID: 17964351, PMCID: PMC3711808, DOI: 10.1016/s0140-6736(07)61636-5.Peer-Reviewed Original ResearchConceptsInfection control strategiesDrug-resistant tuberculosisXDR tuberculosisTuberculosis casesTuberculosis transmissionRural South African district hospitalSouth African district hospitalMask useTugela FerryAfrican district hospitalEffects of HIVInfection control measuresDrug resistance testingCommunity-based dataResource-limited settingsEpidemiological modelling studyCommunity-based programsAntiretroviral therapyNosocomial transmissionHospitalisation timeHIV treatmentOutpatient therapyDistrict hospitalTuberculosis epidemicHospital staff
2006
Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa
Gandhi NR, Moll A, Sturm AW, Pawinski R, Govender T, Lalloo U, Zeller K, Andrews J, Friedland G. Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. The Lancet 2006, 368: 1575-1580. PMID: 17084757, DOI: 10.1016/s0140-6736(06)69573-1.Peer-Reviewed Original ResearchConceptsDrug-resistant tuberculosisCo-infected patientsXDR tuberculosisMDR tuberculosisHIV co-infected patientsCulture-confirmed tuberculosisRecent hospital admissionTime of diagnosisSecond-line drugsDrug susceptibility testingCause of deathDate of deathHigh mortality rateAntiretroviral therapyMedian survivalHospital admissionSputum cultureHIV-1PatientsMortality rateHigh mortalityUrgent interventionTreatment programTuberculosisSusceptibility testing