2019
Renal clearable nanochelators for iron overload therapy
Kang H, Han M, Xue J, Baek Y, Chang J, Hu S, Nam H, Jo M, El Fakhri G, Hutchens M, Choi H, Kim J. Renal clearable nanochelators for iron overload therapy. Nature Communications 2019, 10: 5134. PMID: 31723130, PMCID: PMC6853917, DOI: 10.1038/s41467-019-13143-z.Peer-Reviewed Original ResearchConceptsIron overloadIntravenous injectionDaily sc injectionsUrinary iron excretionSecondary iron overloadIron-overloaded miceAdverse side effectsIron chelatorsIron overload disordersGastrointestinal bleedingSC injectionIron excretionLiver fibrosisSide effectsKidney damageKidney failureIron overload therapyIron levelsToxic ironPharmacokinetic propertiesDeferoxamineNanochelatorKidneyExcretionInjection
2016
Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery
Kang H, Gravier J, Bao K, Wada H, Lee J, Baek Y, Fakhri G, Gioux S, Rubin B, Coll J, Choi H. Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery. Advanced Materials 2016, 28: 8162-8168. PMID: 27414255, PMCID: PMC5155334, DOI: 10.1002/adma.201601101.Peer-Reviewed Original Research