2020
Preclinical Validation of a Single-Scan Rest/Stress Imaging Technique for 13N-Ammonia Positron Emission Tomography Cardiac Perfusion Studies
Guehl N, Pelletier-Galarneau M, Wooten D, Guerrero J, Kas A, Normandin M, Fakhri G, Alpert N. Preclinical Validation of a Single-Scan Rest/Stress Imaging Technique for 13N-Ammonia Positron Emission Tomography Cardiac Perfusion Studies. Circulation Cardiovascular Imaging 2020, 13: e009407. PMID: 31959009, PMCID: PMC7205554, DOI: 10.1161/circimaging.119.009407.Peer-Reviewed Original ResearchConceptsMyocardial blood flowPerfusion imagingMyocardial perfusion imaging proceduresSCAN-ALeft anterior descending arteryDose of adenosineAbsolute myocardial blood flowStress perfusion imagingAnterior descending arteryCardiac perfusion studiesMyocardial blood flow measurementsBland-Altman analysisNonstationary kinetic modelPositron emission tomographyMeasurement of restMyocardial blood flow valuesPharmacological stressorDescending arteryPreclinical validationMyocardial blood flow estimatesSingle-scan acquisitionPerfusion studiesVariable dosesImaging sessionMicrosphere MBF measurements
2009
Reproducibility and Accuracy of Quantitative Myocardial Blood Flow Assessment with 82Rb PET: Comparison with 13N-Ammonia PET
Fakhri G, Kardan A, Sitek A, Dorbala S, Abi-Hatem N, Lahoud Y, Fischman A, Coughlan M, Yasuda T, Di Carli M. Reproducibility and Accuracy of Quantitative Myocardial Blood Flow Assessment with 82Rb PET: Comparison with 13N-Ammonia PET. Journal Of Nuclear Medicine 2009, 50: 1062-1071. PMID: 19525467, PMCID: PMC3133618, DOI: 10.2967/jnumed.104.007831.Peer-Reviewed Original ResearchConceptsCoronary flow reserveMyocardial blood flowQuantitation of myocardial blood flowTime-activity curvesInterobserver reliabilityBaseline myocardial blood flowBlood poolPET studiesAssessment of myocardial perfusionTissue time-activity curvesEstimation of myocardial blood flowMyocardial blood flow quantitationBland-Altman plotsBlood flow assessmentRight ventricular blood poolCompartment analysisMyocardial blood flow assessmentPeak stressVentricular blood poolReproducibility of myocardial blood flowDynamic restCardiac PETEstimation of coronary flow reserveIntraobserver variabilityMyocardial perfusion