2022
Impact of 40 Hz Transcranial Alternating Current Stimulation on Cerebral Tau Burden in Patients with Alzheimer’s Disease: A Case Series1
Dhaynaut M, Sprugnoli G, Cappon D, Macone J, Sanchez J, Normandin M, Guehl N, Koch G, Paciorek R, Connor A, Press D, Johnson K, Pascual-Leone A, Fakhri G, Santarnecchi E. Impact of 40 Hz Transcranial Alternating Current Stimulation on Cerebral Tau Burden in Patients with Alzheimer’s Disease: A Case Series1. Journal Of Alzheimer's Disease 2022, 85: 1667-1676. PMID: 34958021, PMCID: PMC9023125, DOI: 10.3233/jad-215072.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseAmyloid beta-PeptidesAnimalsBrainEntorhinal CortexFemaleHumansMaleMiceMicrogliaPositron-Emission TomographyTau ProteinsTemporal LobeTranscranial Direct Current StimulationConceptsMicroglia activationGamma spectral powerDecrease of microglia activationNo adverse eventsTranscranial alternating current stimulationSlow disease progressionPlacebo-controlled conditionsPreclinical dataCase seriesAdverse eventsGamma oscillationsElectrophysiological assessmentP-tauMouse modelDisease progressionMesial regionMild to moderate ADAnimal modelsPatientsPET imagingAlzheimer's diseaseSpectral powerAD mouse modelAD patientsProtein clearance
2021
Toward noninvasive brain stimulation 2.0 in Alzheimer’s disease
Menardi A, Rossi S, Koch G, Hampel H, Vergallo A, Nitsche M, Stern Y, Borroni B, Cappa S, Cotelli M, Ruffini G, El-Fakhri G, Rossini P, Dickerson B, Antal A, Babiloni C, Lefaucheur J, Dubois B, Deco G, Ziemann U, Pascual-Leone A, Santarnecchi E. Toward noninvasive brain stimulation 2.0 in Alzheimer’s disease. Ageing Research Reviews 2021, 75: 101555. PMID: 34973457, PMCID: PMC8858588, DOI: 10.1016/j.arr.2021.101555.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseBrainCognitionHumansTranscranial Direct Current StimulationTranscranial Magnetic StimulationImpact of multisession 40Hz tACS on hippocampal perfusion in patients with Alzheimer’s disease
Sprugnoli G, Munsch F, Cappon D, Paciorek R, Macone J, Connor A, El Fakhri G, Salvador R, Ruffini G, Donohoe K, Shafi M, Press D, Alsop D, Pascual Leone A, Santarnecchi E. Impact of multisession 40Hz tACS on hippocampal perfusion in patients with Alzheimer’s disease. Alzheimer's Research & Therapy 2021, 13: 203. PMID: 34930421, PMCID: PMC8690894, DOI: 10.1186/s13195-021-00922-4.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseCognitive DysfunctionHippocampusHumansPerfusionTranscranial Direct Current StimulationConceptsTemporal lobeMethodsIn two open-label studiesMild to moderate AD participantsPreclinical models of ADGamma bandBrain oscillatory activityModerate AD participantsBilateral temporal lobesEpisodic memoryAdministered 1 hSpectral power changesBrain areasModulates cerebral perfusionAD participantsPlacebo-controlled trialHippocampal perfusionModel of ADOpen-label studyNeural activityAssociated with alterationsNon-invasive countermeasureCognitive AssessmentCognitive impairmentCognitive protectionOscillatory activity