2008
Sequential and simultaneous dual‐isotope brain SPECT: Comparison with PET for estimation and discrimination tasks in early Parkinson disease
Trott C, Fakhri G. Sequential and simultaneous dual‐isotope brain SPECT: Comparison with PET for estimation and discrimination tasks in early Parkinson disease. Medical Physics 2008, 35: 3343-3353. PMID: 18697558, PMCID: PMC2673561, DOI: 10.1118/1.2940605.Peer-Reviewed Original ResearchConceptsEnergy resolutionTime-of-flight PET scannerRealistic Monte Carlo simulationsAcquisition energy windowSequential SPECTSystem energy resolutionGamma cameraEnergy windowThree-head cameraPET scannerEmission energyMonte Carlo simulationsDual-isotope SPECTSimultaneous SPECTBrain PETTwo-headed cameraCarlo simulationsProdromal disease stagesIdentical physiological conditionsSpatial resolutionDiscrimination taskStriatal sizeActivity concentrationsEarly identification of PDCamera head
2007
Fast Monte Carlo based joint iterative reconstruction for simultaneous SPECT imaging
Ouyang J, Fakhri G, Moore S. Fast Monte Carlo based joint iterative reconstruction for simultaneous SPECT imaging. Medical Physics 2007, 34: 3263-3272. PMID: 17879789, DOI: 10.1118/1.2756601.Peer-Reviewed Original ResearchConceptsMC-JOSEMEnergy windowFast Monte CarloSignal-to-noise ratioScatter correction methodOrdered-subsets expectation-maximizationMonte CarloOrdered-subsets expectation-maximization algorithmIterative reconstruction algorithmPrimary photonsReconstruction algorithmPhoton transportSeptal penetrationDetector responseMC simulationsIterative reconstructionAttenuation distributionStandard OSEMPhotonsProjection dataPatient-specific activityDetectorReconstructed imagesScatteringEstimation of scattering