2015
National Electrical Manufacturers Association and Clinical Evaluation of a Novel Brain PET/CT Scanner
Grogg K, Toole T, Ouyang J, Zhu X, Normandin M, Li Q, Johnson K, Alpert N, Fakhri G. National Electrical Manufacturers Association and Clinical Evaluation of a Novel Brain PET/CT Scanner. Journal Of Nuclear Medicine 2015, 57: 646-652. PMID: 26697961, PMCID: PMC4818715, DOI: 10.2967/jnumed.115.159723.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainElectric Power SuppliesHumansNeuroimagingPhantoms, ImagingPositron-Emission TomographyReproducibility of ResultsSafetyScattering, RadiationConceptsNoise-equivalent count rateCount rateLoose cutsMaximum noise-equivalent counting rateSpatial resolutionDetector ringSilicon photomultipliersBrain phantomContrast recoveryAttenuation correctionPET/CT systemCrystal blockPET/CT scannerImage qualityRadial offsetNational Electrical Manufacturers AssociationActivity distributionUnique mobility capabilitiesAxial extentTransverse resolutionPhantomAxial resolutionActivity concentrationsHuman scansLayer 1 cm
2013
Clinical Application of In-Room Positron Emission Tomography for In Vivo Treatment Monitoring in Proton Radiation Therapy
Min C, Zhu X, Winey B, Grogg K, Testa M, Fakhri G, Bortfeld T, Paganetti H, Shih H. Clinical Application of In-Room Positron Emission Tomography for In Vivo Treatment Monitoring in Proton Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2013, 86: 183-189. PMID: 23391817, PMCID: PMC3640852, DOI: 10.1016/j.ijrobp.2012.12.010.Peer-Reviewed Original ResearchConceptsIn-room positron emission tomographyProton therapyIn-roomPositron emission tomography scanIn-room PET scannerPassive scattering proton therapyShapes of target volumesPositron emission tomographyMC predictionBeam range uncertaintiesMeasured PET imagesMonte CarloProton radiation therapyLocal elemental compositionBiological washoutScan timeTreatment headTreatment verificationRange uncertaintiesTarget volumePET scan timePET scannerPET systemComputed tomographyMC results
2011
Nonrigid PET motion compensation in the lower abdomen using simultaneous tagged‐MRI and PET imaging
Guérin B, Cho S, Chun S, Zhu X, Alpert N, Fakhri G, Reese T, Catana C. Nonrigid PET motion compensation in the lower abdomen using simultaneous tagged‐MRI and PET imaging. Medical Physics 2011, 38: 3025-3038. PMID: 21815376, PMCID: PMC3125080, DOI: 10.1118/1.3589136.Peer-Reviewed Original ResearchConceptsPET-MRI acquisitionsMotion correctionPET motion compensationPET motion correctionRespiratory motion correctionMotion-corrected reconstructionMotion correction strategiesWhole-body PET studiesSignal-to-noise ratioPET reconstruction algorithmDeformable phantomNCAT phantomEffects of motionAttenuation mapDetected coincidencesPET-MRIGated framesBrain scannerSimulations of tumorsSignal-to-noisePhantomSusceptibility artifactsReconstruction algorithmPhase domainsNonrigid deformation
2008
Improved activity estimation with MC‐JOSEM versus TEW‐JOSEM in SPECT
Ouyang J, Fakhri G, Moore S. Improved activity estimation with MC‐JOSEM versus TEW‐JOSEM in SPECT. Medical Physics 2008, 35: 2029-2040. PMID: 18561679, PMCID: PMC2673642, DOI: 10.1118/1.2907561.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsEquipment DesignImage Processing, Computer-AssistedIndium RadioisotopesLungModels, StatisticalMonte Carlo MethodPhantoms, ImagingRadiotherapy Planning, Computer-AssistedReproducibility of ResultsScattering, RadiationSoftwareTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsMC-JOSEMWater-filled torso phantomMC scatter estimationTriple-energy-windowActivity estimationIterative reconstruction algorithmTorso phantomPhantom studyBackground compartmentScatter estimationActivity distributionAverage relative biasPhantomReconstruction algorithmActivity concentrationsSynthetic projectionsSphere locationScattering
2000
Relative impact of scatter, collimator response, attenuation, and finite spatial resolution corrections in cardiac SPECT.
El Fakhri G, Buvat I, Benali H, Todd-Pokropek A, Di Paola R. Relative impact of scatter, collimator response, attenuation, and finite spatial resolution corrections in cardiac SPECT. Journal Of Nuclear Medicine 2000, 41: 1400-8. PMID: 10945534.Peer-Reviewed Original ResearchConceptsDepth-dependent collimator responseSpatial resolution correctionCollimator responseFinite spatial resolutionBull's-eye mapCardiac SPECTActivity quantitationAttenuation correctionScatter correctionResolution correctionSpatial resolutionCollimator response correctionsSignal-to-noise ratioFrequency-distance principleImpact of scatteringLeft ventricleMonte Carlo simulationsCardiac phantomScatteringCarlo simulationsLV cavityAbsolute quantitationImproved contrastLV regionsProcessing schemeShould scatter be corrected in both transmission and emission data for accurate quantitation in cardiac SPET?
El Fakhri G, Buvat I, Almeida P, Bendriem B, Todd-Pokropek A, Benali H. Should scatter be corrected in both transmission and emission data for accurate quantitation in cardiac SPET? European Journal Of Nuclear Medicine And Molecular Imaging 2000, 27: 1356-1364. PMID: 11007518, DOI: 10.1007/s002590000304.Peer-Reviewed Original ResearchConceptsTransmission dataSingle-photon emission tomographyActivity distributionSignal-to-noise ratioCardiac single-photon emission tomographyAttenuation-corrected imagesAmount of scatterNarrow transmission windowHot compartmentActivity quantitationTransmission scanEmission dataEmission acquisitionTransmission windowReduced signal-to-noise ratioTransmission scatteringScatteringScattering componentPhantomQuantitative accuracyReduced scatteringAttenuating mediaReconstructed imagesLine sourceEmission
1998
Artificial neural network as a tool to compensate for scatter and attenuation in radionuclide imaging.
Maksud P, Fertil B, Rica C, El Fakhri G, Aurengo A. Artificial neural network as a tool to compensate for scatter and attenuation in radionuclide imaging. Journal Of Nuclear Medicine 1998, 39: 735-45. PMID: 9544691.Peer-Reviewed Original ResearchMeSH KeywordsBone and BonesHumansImage EnhancementMaleMiddle AgedMonte Carlo MethodNeural Networks, ComputerPhantoms, ImagingRadionuclide ImagingScattering, RadiationConceptsEnergy spectrumCompton scatteringRadioactive sourcesImages of radioactive sourcesScatter correctionArtificial neural networkNeural networkNumerical Monte Carlo simulationsMonte Carlo simulationsPelvis scansIncident photonsMultilayer neural networkProjection imagesScatteringComptonCarlo simulationsDiffusion mediaSource distributionSpectrum acquisitionEnergyGeometric sourcesHomogeneous mediumCorrectionSpectraNetwork