2021
Personalised, image-guided, noninvasive brain stimulation in gliomas: Rationale, challenges and opportunities
Sprugnoli G, Rossi S, Rotenberg A, Pascual-Leone A, El-Fakhri G, Golby A, Santarnecchi E. Personalised, image-guided, noninvasive brain stimulation in gliomas: Rationale, challenges and opportunities. EBioMedicine 2021, 70: 103514. PMID: 34391090, PMCID: PMC8365310, DOI: 10.1016/j.ebiom.2021.103514.Peer-Reviewed Original ResearchConceptsHigh-grade gliomasNeuronal activityBrain tumorsProximity of tumor cellsSlow tumor growthAggressive human cancersMalignant brain tumorsBrain stimulationTumor mitosisHealthy brain tissuePatient survivalMechanism of actionImage-guidedTumor cellsTumor growthSynaptic activityHuman cancersTumorTherapeutic interventionsClinical settingNoninvasive brain stimulationElectrical stimulationWhole-brain levelPatientsBrain tissue
2018
Subject-specific brain tumor growth modelling via an efficient Bayesian inference framework
Chang Y, Sharp G, Li Q, Shih H, El Fakhri G, Ra J, Woo J. Subject-specific brain tumor growth modelling via an efficient Bayesian inference framework. Proceedings Of SPIE--the International Society For Optical Engineering 2018, 10574: 105742i. PMID: 30050231, PMCID: PMC6056378, DOI: 10.1117/12.2293145.Peer-Reviewed Original ResearchTumor growthOptimal treatmentExternal beam radiotherapyBrain tumor progressionBeam radiotherapyBrain tumor growthTumor growth modelTumor infiltrationTumor parametersTumor progressionEffective therapyClinical dataTherapy planningTumorIndividualized therapyTherapyTumor boundariesProliferation rateRadiotherapyNon-invasiveState-of-the-art methodsTreatmentState-of-the-artChemotherapy