2015
Mapping 15O Production Rate for Proton Therapy Verification
Grogg K, Alpert N, Zhu X, Min C, Testa M, Winey B, Normandin M, Shih H, Paganetti H, Bortfeld T, Fakhri G. Mapping 15O Production Rate for Proton Therapy Verification. International Journal Of Radiation Oncology • Biology • Physics 2015, 92: 453-459. PMID: 25817530, PMCID: PMC4431894, DOI: 10.1016/j.ijrobp.2015.01.023.Peer-Reviewed Original ResearchConceptsDecay constantProton treatment planningMonte Carlo predictionsProton therapyPhantom materialTreatment deliveryPhantomThigh activityPositron emission tomographyProduction rateDynamic PET measurementsTreatment planningRabbit thigh muscleClearance rateProtonIsotopesChanges due to therapyRadionuclide speciesOxygen-15ConstantDecayImaging targetsMontePositronEffects of perfusion
2013
Determination of elemental tissue composition following proton treatment using positron emission tomography
Cho J, Ibbott G, Gillin M, Gonzalez-Lepera C, Min C, Zhu X, Fakhri G, Paganetti H, Mawlawi O. Determination of elemental tissue composition following proton treatment using positron emission tomography. Physics In Medicine And Biology 2013, 58: 3815-3835. PMID: 23681070, PMCID: PMC3763743, DOI: 10.1088/0031-9155/58/11/3815.Peer-Reviewed Original ResearchConceptsIn-room PET scannerProton treatmentSOBP beamPET scannerMonte Carlo simulationsTissue elemental compositionComposite decay curvePristine Bragg peakProton treatment planningIn-roomElemental tissue compositionCarlo simulationsDecay curvesRange verificationMonoenergetic beamsBeam rangeProton dosePhantom sectionsEmitted positronsPositron emission tomographyProton therapyBragg peakPhantom compositionDelivered dosePositron emission tomography imaging