2019
Real‐Time Imaging of Vaccine Biodistribution Using Zwitterionic NIR Nanoparticles
Katagiri W, Lee J, Tétrault M, Kang H, Jeong S, Evans C, Yokomizo S, Santos S, Jones C, Hu S, Fakhri G, Tsukada K, Choi H, Kashiwagi S. Real‐Time Imaging of Vaccine Biodistribution Using Zwitterionic NIR Nanoparticles. Advanced Healthcare Materials 2019, 8: e1900035. PMID: 31165556, PMCID: PMC6687515, DOI: 10.1002/adhm.201900035.Peer-Reviewed Original ResearchConceptsNIR fluorescence imaging systemLymph nodesVaccine antigensClinical vaccine candidatesOptimization of vaccine designFluorescence imaging systemAntigen presenting cellsInduce protective immune responsesSecondary lymphoid tissuesDelivery of vaccine antigensProtective immune responsesZwitterionic NIR fluorophoreFlow cytometry analysisPresenting cellsLymphoid tissueIntradermal administrationAdverse reactionsBioconjugate vaccineImmune responseVaccine designVaccine candidatesModel vaccineCytometry analysisZwitterionic fluorophoresAntigen
2015
Heat‐Induced Radiolabeling of Nanoparticles for Monocyte Tracking by PET
Normandin M, Yuan H, Wilks M, Chen H, Kinsella J, Cho H, Guehl N, Absi‐Halabi N, Hosseini S, Fakhri G, Sosnovik D, Josephson L. Heat‐Induced Radiolabeling of Nanoparticles for Monocyte Tracking by PET. Angewandte Chemie 2015, 127: 13194-13198. DOI: 10.1002/ange.201505525.Peer-Reviewed Original ResearchPositron emission tomographyRadiolabelling of nanoparticlesStandardized uptake valueMonocytes in vitroNP pharmacokineticsSlow uptake processUptake valueLymph nodesCirculating monocytesMonocyte traffickingIV injectionImmune responseBlood clearanceEmission tomographyHepatic uptakeMonocytesPharmacokineticsLymphUptake processHeat‐Induced Radiolabeling of Nanoparticles for Monocyte Tracking by PET
Normandin M, Yuan H, Wilks M, Chen H, Kinsella J, Cho H, Guehl N, Absi‐Halabi N, Hosseini S, Fakhri G, Sosnovik D, Josephson L. Heat‐Induced Radiolabeling of Nanoparticles for Monocyte Tracking by PET. Angewandte Chemie International Edition 2015, 54: 13002-13006. PMID: 26368132, PMCID: PMC4754124, DOI: 10.1002/anie.201505525.Peer-Reviewed Original ResearchConceptsPositron emission tomographyRadiolabelling of nanoparticlesStandardized uptake valueNP pharmacokineticsSlow uptake processUptake valueLymph nodesCirculating monocytesMonocyte traffickingIV injectionImmune responseBlood clearanceEmission tomographyHepatic uptakeMonocytesPharmacokineticsLymphUptake processCytometry