2021
In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker
Mody M, Petibon Y, Han P, Kuruppu D, Ma C, Yokell D, Neelamegam R, Normandin M, Fakhri G, Brownell A. In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker. Scientific Reports 2021, 11: 15897. PMID: 34354107, PMCID: PMC8342610, DOI: 10.1038/s41598-021-94967-y.Peer-Reviewed Original ResearchConceptsFragile X syndromeFragile X mental retardation proteinX syndromeLoss of fragile X mental retardation proteinMGlu5 receptor expressionMetabotropic glutamate subtype 5 receptorsDrug occupancy studiesSignificant group differencesFragile X mental retardationHealthy controlsAnterior cingulateMGluR5 availabilityVisuospatial processingMGlu5 receptorsOlfactory cortexBrain areasGroup differencesRetardation proteinGlutamate signalingImages of maleNeurodevelopmental disordersExcessive glutamate signalingGender-matched controlsDisordersMGluR5
2003
MRI-Guided SPECT Perfusion Measures and Volumetric MRI in Prodromal Alzheimer Disease
El Fakhri G, Kijewski M, Johnson K, Syrkin G, Killiany R, Becker J, Zimmerman R, Albert M. MRI-Guided SPECT Perfusion Measures and Volumetric MRI in Prodromal Alzheimer Disease. JAMA Neurology 2003, 60: 1066-1072. PMID: 12925361, DOI: 10.1001/archneur.60.8.1066.Peer-Reviewed Original ResearchConceptsRostral anterior cingulateCaudal anterior cingulateMagnetic resonance imagingAnterior cingulateSuperior temporal sulcusPosterior cingulateBasal forebrainTemporal hornEntorhinal cortexTemporal sulcusGroup differencesMemory problemsNondemented patientsFollow-upQuantitative single-photon emissionProdromal phase of Alzheimer's diseaseReceiver operating characteristic curve analysisYears of follow-upAlzheimer's diseasePhase of Alzheimer's diseaseCharacteristic curve analysisVolumetric magnetic resonance imagingMagnetic resonance imaging analysisMagnetic resonance imaging measuresSPECT analysis