2008
Sequential and simultaneous dual‐isotope brain SPECT: Comparison with PET for estimation and discrimination tasks in early Parkinson disease
Trott C, Fakhri G. Sequential and simultaneous dual‐isotope brain SPECT: Comparison with PET for estimation and discrimination tasks in early Parkinson disease. Medical Physics 2008, 35: 3343-3353. PMID: 18697558, PMCID: PMC2673561, DOI: 10.1118/1.2940605.Peer-Reviewed Original ResearchConceptsEnergy resolutionTime-of-flight PET scannerRealistic Monte Carlo simulationsAcquisition energy windowSequential SPECTSystem energy resolutionGamma cameraEnergy windowThree-head cameraPET scannerEmission energyMonte Carlo simulationsDual-isotope SPECTSimultaneous SPECTBrain PETTwo-headed cameraCarlo simulationsProdromal disease stagesIdentical physiological conditionsSpatial resolutionDiscrimination taskStriatal sizeActivity concentrationsEarly identification of PDCamera head
2007
Comparison of Brain PET and Sequential and Simultaneous Dual-isotope SPECT for Estimation Tasks in Normal and Parkinson Subjects
Trott C, Fakhri G. Comparison of Brain PET and Sequential and Simultaneous Dual-isotope SPECT for Estimation Tasks in Normal and Parkinson Subjects. 2007, 5: 3616-3620. DOI: 10.1109/nssmic.2007.4436906.Peer-Reviewed Original ResearchDopamine transporterEarly stages of PDDual-isotope SPECTStages of PDSequential SPECTDisease stageSimultaneous dual-isotope studyStriatal sizeBrain functionImprove patient managementEstimation taskDual-isotope studiesBrain PETDopamineClinical symptomsParkinson's diseasePatient managementSPECT imagesSpecific bindingMotor functionSPECTBrainEarly detectionActivity concentrationsIdentical physiological conditions
2005
Quantitative simultaneous 99mTc-ECD/123I-FP-CIT SPECT in Parkinson’s disease and multiple system atrophy
El Fakhri G, Habert M, Maksud P, Kas A, Malek Z, Kijewski M, Lacomblez L. Quantitative simultaneous 99mTc-ECD/123I-FP-CIT SPECT in Parkinson’s disease and multiple system atrophy. European Journal Of Nuclear Medicine And Molecular Imaging 2005, 33: 87-92. PMID: 16180033, DOI: 10.1007/s00259-005-1920-y.Peer-Reviewed Original ResearchConceptsMultiple system atrophyIdiopathic Parkinson's diseaseDopamine transporterDopamine transporter binding potentialNormal controlsVoxel-based statistical parametric mappingAsymmetry indexMultiple system atrophy patientsCompared to normal controlsCaudate nucleusDifferential diagnosis of idiopathic Parkinson’s diseaseDiagnosis of parkinsonian syndromesPatient-specific attenuationDiagnosis of idiopathic Parkinson's diseaseBinding potentialIdiopathic Parkinson's disease patientsDual-isotope SPECTVariable collimator responseParkinson's diseaseDifferential diagnosisDecreased perfusionStatistical parametric mappingPurposeThe purposeSystem atrophyParkinsonian syndromes