2024
Associations of cerebral amyloid beta and tau with cognition from midlife
Gonzales M, O'Donnell A, Ghosh S, Thibault E, Tanner J, Satizabal C, Decarli C, Fakhri G, Johnson K, Beiser A, Seshadri S, Pase M. Associations of cerebral amyloid beta and tau with cognition from midlife. Alzheimer's & Dementia 2024, 20: 5901-5911. PMID: 39039896, PMCID: PMC11497641, DOI: 10.1002/alz.14060.Peer-Reviewed Original ResearchApolipoprotein E e4Associated with cognitionTau positron emission tomographyPositron emission tomographyWorsening cognitionCommunity-based cohortYoung adultsApolipoprotein EStudy investigated associationsPoor visuospatial skillsDementia preventionTargeted early interventionE4 statusCerebral amyloid-betaEffect modifiersHigher amyloidAPOE e4 carriersCognitive vulnerabilityAssociation of amyloidVisuospatial skillsResilience factorsEarly interventionYounger ageCognitionE4 carriers
2023
Association of Pathologic and Volumetric Biomarker Changes With Cognitive Decline in Clinically Normal Adults
Hanseeuw B, Jacobs H, Schultz A, Buckley R, Farrell M, Guehl N, Becker J, Properzi M, Sanchez J, Quiroz Y, Vannini P, Sepulcre J, Yang H, Chhatwal J, Gatchel J, Marshall G, Amariglio R, Papp K, Rentz D, Normandin M, Price J, Healy B, El Fakhri G, Sperling R, Johnson K. Association of Pathologic and Volumetric Biomarker Changes With Cognitive Decline in Clinically Normal Adults. Neurology 2023, 101: e2533-e2544. PMID: 37968130, PMCID: PMC10791053, DOI: 10.1212/wnl.0000000000207962.Peer-Reviewed Original ResearchConceptsAssociated with cognitive declineOlder adultsNon-AD pathologyCognitive declineHippocampal volumeCognitive dataPreclinical Alzheimer Cognitive CompositeInferior temporal tauProspective cohort studyClinically normal older adultsHarvard Aging Brain StudyPittsburgh compound B PET scansOvert cognitive impairmentAnalyzed dataNormal older adultsAging Brain StudyClinically normal adultsLongitudinal associationsAlzheimer's diseaseCohort studyMemory impairmentCognitive compositeCognitive impairmentHippocampal atrophyCognition
2022
Longitudinal hippocampal atrophy is associated with cognitive decline independently of amyloid and tau in neocortex
Hanseeuw B, Jacobs H, Schultz A, Buckley R, Properzi M, Becker A, Farrell M, Sanchez J, Papp K, Yang H, Chhatwal J, Price J, Fakhri G, Rentz D, Sperling R, Johnson K. Longitudinal hippocampal atrophy is associated with cognitive decline independently of amyloid and tau in neocortex. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.069271.Peer-Reviewed Original ResearchLower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals
Prokopiou P, Engels-Domínguez N, Papp K, Scott M, Schultz A, Schneider C, Farrell M, Buckley R, Quiroz Y, El Fakhri G, Rentz D, Sperling R, Johnson K, Jacobs H. Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals. Nature Communications 2022, 13: 1571. PMID: 35322012, PMCID: PMC8943159, DOI: 10.1038/s41467-022-28986-2.Peer-Reviewed Original ResearchConceptsCognitive declineLC activityLC-FCFunctional connectivityLocus coeruleusAssociated with altered neuronal activityNeuronal activityFace-name paradigmAD-related cognitive declineHuman imaging researchIn vivo neuronal activityLongitudinal cognitive dataAssociated with cognitive declineBeta-amyloid-PETIndividuals at-riskAlzheimer's diseaseCognitively unimpaired older individualsBeta-amyloidSubcortical regionsFunctional MRICognitive dataNeurofibrillary tauImaging researchHippocampusCognition