2024
PET imaging of M4 muscarinic acetylcholine receptors in rhesus macaques using [11C]MK-6884: Quantification with kinetic modeling and receptor occupancy by CVL-231 (emraclidine), a novel positive allosteric modulator
Belov V, Guehl N, Duvvuri S, Iredale P, Moon S, Dhaynaut M, Chakilam S, MacDonagh A, Rice P, Yokell D, Renger J, Fakhri G, Normandin M. PET imaging of M4 muscarinic acetylcholine receptors in rhesus macaques using [11C]MK-6884: Quantification with kinetic modeling and receptor occupancy by CVL-231 (emraclidine), a novel positive allosteric modulator. Cerebrovascular And Brain Metabolism Reviews 2024, 44: 1329-1342. PMID: 38477292, PMCID: PMC11342722, DOI: 10.1177/0271678x241238820.Peer-Reviewed Original ResearchConceptsPositive allosteric modulatorsReceptor occupancyNon-human primatesBinding potentialPositron emission tomographyMuscarinic acetylcholine receptorsAllosteric modulatorsNon-human primate brainM4 muscarinic acetylcholine receptorStriatal hyperdopaminergiaAcetylcholine receptorsBrain regionsCaudate nucleusTotal volume of distributionDose-dependent blockReference regionVolume of distributionPositron emission tomography imagingEmission tomographyReceptor levelsFunction of dosePET scansClinical trialsBlood-basedRhesus macaques
2012
In Vivo Treatment Verification Using In-room PET in Proton Radiation Therapy: First Clinical Trials and Evaluation of Short-length Scan
Min C, Zhu X, Winey B, Grogg K, Fakhri G, Bortfeld T, Paganetti H, Shih H. In Vivo Treatment Verification Using In-room PET in Proton Radiation Therapy: First Clinical Trials and Evaluation of Short-length Scan. International Journal Of Radiation Oncology • Biology • Physics 2012, 84: s53-s54. DOI: 10.1016/j.ijrobp.2012.07.347.Peer-Reviewed Original ResearchMO‐A‐213AB‐07: Evaluation of Distal Dose Surface with In‐Room PET for Proton Therapy Monitoring
Min C, Zhu X, Grogg K, Winey B, Fakhri G, Bortfeld T, Shih H, Paganetti H. MO‐A‐213AB‐07: Evaluation of Distal Dose Surface with In‐Room PET for Proton Therapy Monitoring. Medical Physics 2012, 39: 3860-3860. PMID: 28517508, DOI: 10.1118/1.4735759.Peer-Reviewed Original ResearchProton dose distributionsMeasured PET imagesDose surfaceDose distributionIn-roomMonte CarloProton therapy monitoringBeam's eye viewPET activitySimulated PET imagesPET imagingGantry roomsTreatment verificationTreatment headBeam deliveryClinical trialsProton therapyPassive scatteringMC simulationsBeam directionTreated volumeRoot-mean-square deviationBeamImage registrationSimulated PET