2021
A cross-scanner and cross-tracer deep learning method for the recovery of standard-dose imaging quality from low-dose PET
Xue S, Guo R, Bohn K, Matzke J, Viscione M, Alberts I, Meng H, Sun C, Zhang M, Zhang M, Sznitman R, El Fakhri G, Rominger A, Li B, Shi K. A cross-scanner and cross-tracer deep learning method for the recovery of standard-dose imaging quality from low-dose PET. European Journal Of Nuclear Medicine And Molecular Imaging 2021, 49: 1843-1856. PMID: 34950968, PMCID: PMC9015984, DOI: 10.1007/s00259-021-05644-1.Peer-Reviewed Original ResearchConceptsStructural similarity index measurePET imagingGenerative adversarial networkNuclear medicine physiciansArtificial intelligenceLow-dose scansBaseline image qualityDose reductionConditional generative adversarial networkClinical imaging assessmentSimilarity index measureDiversity of clinical practiceDevelopment of AI technologyDeep learning developmentDose acquisitionImaging assessmentMedicine physiciansImage qualityResultsThe improvementPatientsClinical acceptanceClinical practiceClinical settingAdversarial networkLow-dose PETQuantitative PET in the 2020s: a roadmap
Meikle S, Sossi V, Roncali E, Cherry S, Banati R, Mankoff D, Jones T, James M, Sutcliffe J, Ouyang J, Petibon Y, Ma C, El Fakhri G, Surti S, Karp J, Badawi R, Yamaya T, Akamatsu G, Schramm G, Rezaei A, Nuyts J, Fulton R, Kyme A, Lois C, Sari H, Price J, Boellaard R, Jeraj R, Bailey D, Eslick E, Willowson K, Dutta J. Quantitative PET in the 2020s: a roadmap. Physics In Medicine And Biology 2021, 66: 06rm01. PMID: 33339012, PMCID: PMC9358699, DOI: 10.1088/1361-6560/abd4f7.Peer-Reviewed Original ResearchMeSH KeywordsArtificial IntelligenceHistory, 20th CenturyHistory, 21st CenturyHumansImage Processing, Computer-AssistedImaging, Three-DimensionalKineticsMedical OncologyNeoplasmsPositron Emission Tomography Computed TomographyPositron-Emission TomographyPrognosisRadiopharmaceuticalsSystems BiologyTomography, X-Ray ComputedConceptsTime-of-flight positron emission tomographyStatistical image reconstructionTotal-body positron emission tomographyPositron emission tomographyQuantitative positron emission tomographyImage reconstructionWhole-body positron emission tomographySensitivity of positron emission tomographyCapabilities of positron emission tomographyImage qualityClinical applicationTracer principleRelevant parametersOncology applicationsPhysicsStatistical qualityExpansion of applicationsEmission tomographyClinical practicePET/MRBiologically relevant parametersSensitive biomarkerPositron
2016
A novel approach to assess the treatment response using Gaussian random field in PET
Wang M, Guo N, Hu G, El Fakhri G, Zhang H, Li Q. A novel approach to assess the treatment response using Gaussian random field in PET. Medical Physics 2016, 43: 833-842. PMID: 26843244, PMCID: PMC4714995, DOI: 10.1118/1.4939879.Peer-Reviewed Original ResearchConceptsTherapy response assessmentStandardized uptake valuePositron emission tomographyEarly treatment responseResponse assessmentPositron emission tomography imagingTreatment responseTherapy responsePrediction of early treatment responseTreatment planningResponse to anticancer therapyTherapy response evaluationTumor-to-background contrastPost-therapy imagingClinical practiceEvaluate therapy responseReceiver operating characteristic curveDevelopment of personalized treatment plansEvaluate therapy effectsPersonalized treatment plansUptake valuePretherapy imagingClinical oncologyPatient managementAnticancer therapy
2014
Effect of time‐of‐flight and point spread function modeling on detectability of myocardial defects in PET
Schaefferkoetter J, Ouyang J, Rakvongthai Y, Nappi C, El Fakhri G. Effect of time‐of‐flight and point spread function modeling on detectability of myocardial defects in PET. Medical Physics 2014, 41: 062502. PMID: 24877836, PMCID: PMC4032408, DOI: 10.1118/1.4875725.Peer-Reviewed Original ResearchConceptsSignal-to-noise ratioDetection signal-to-noise ratioPoint spread functionObserver signal-to-noise ratioEffects of time-of-flightMyocardial defectsHuman observer performanceDefect detectionSlow convergenceTime-of-flight (TOFNon-PSFPostreconstruction smoothingFDG-PET dataTime-of-flightPSF reconstructionCombination of TOFNon-TOFIterationObserver performanceClinical practiceSpread functionReconstruction parametersReconstruction protocolsIterative methodDetection