2011
Targeting ST2L Potentiates CpG-Mediated Therapeutic Effects in a Chronic Fungal Asthma Model
Ramaprakash H, Shibata T, Duffy KE, Ismailoglu UB, Bredernitz RM, Moreira AP, Coelho AL, Das AM, Fursov N, Chupp GL, Hogaboam CM. Targeting ST2L Potentiates CpG-Mediated Therapeutic Effects in a Chronic Fungal Asthma Model. American Journal Of Pathology 2011, 179: 104-115. PMID: 21640974, PMCID: PMC3123853, DOI: 10.1016/j.ajpath.2011.03.032.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAspergillosis, Allergic BronchopulmonaryAspergillus fumigatusAsthmaBlotting, WesternBronchial HyperreactivityCase-Control StudiesChemokine CXCL9Chronic DiseaseDisease Models, AnimalEnzyme-Linked Immunosorbent AssayFemaleFibrosisHumansImmunoenzyme TechniquesImmunoglobulin GLungMiceMice, Inbred C57BLOligodeoxyribonucleotidesReceptors, Interleukin-1Reverse Transcriptase Polymerase Chain ReactionRNA, MessengerToll-Like Receptor 9ConceptsAsthmatic miceExperimental asthmaDendritic cellsTherapeutic effectDay 28Live A. fumigatus conidiaControl dendritic cellsMucus cell metaplasiaKey pathological featureCell-associated receptorsA. fumigatus conidiaProtein expression levelsAirway hyperresponsivenessCXCL9 levelsFungal asthmaPeribronchial fibrosisAsthma modelIL-12p70Time-dependent mannerAllergic inflammationAsthma severityCell metaplasiaIL-33Therapeutic blockadeC57BL/6 mice
2006
Hyperoxia causes angiopoietin 2–mediated acute lung injury and necrotic cell death
Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA. Hyperoxia causes angiopoietin 2–mediated acute lung injury and necrotic cell death. Nature Medicine 2006, 12: 1286-1293. PMID: 17086189, PMCID: PMC2768268, DOI: 10.1038/nm1494.Peer-Reviewed Original ResearchMeSH KeywordsAngiopoietin-2AnimalsCell DeathHyperoxiaMicePulmonary EdemaRNA, MessengerRNA, Small InterferingConceptsAcute lung injuryHyperoxic acute lung injuryLung injuryPulmonary edemaEpithelial necrosisAlveolar edema fluidSiRNA-treated miceCell deathLung epithelial cellsEndothelial cell apoptosisBronchopulmonary dysplasiaVascular leakAngiopoietin-2Edema fluidOxidant injuryAng2 expressionHyperoxiaAng2Vascular regressionBlood vesselsCell apoptosisInjuryNecrotic cell deathEpithelial cellsCell death pathways