2014
Methylmercury-Induced Inhibition of Paraoxonase-1 (PON1)—Implications for Cardiovascular Risk
Ginsberg G, Sonawane B, Nath R, Lewandowski P. Methylmercury-Induced Inhibition of Paraoxonase-1 (PON1)—Implications for Cardiovascular Risk. Journal Of Toxicology And Environmental Health Part A 2014, 77: 1004-1023. PMID: 25072822, DOI: 10.1080/15287394.2014.919837.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntioxidantsAryldialkylphosphataseCarboxylic Ester HydrolasesCardiovascular DiseasesDisease Models, AnimalDose-Response Relationship, DrugFatty Acids, Omega-3FishesFood ContaminationHumansLipid MetabolismMeatMethylmercury CompoundsMiceReactive Oxygen SpeciesRisk AssessmentRisk FactorsConceptsCardiovascular riskParaoxonase 1PON1 activityDoses of MeHgAcute cardiovascular eventsSerum PON1 activityHigh-density lipoproteinCardiovascular eventsBlood lipidsMeHg doseCardiovascular healthFish-eating populationsCardiovascular diseaseCardioprotective factorPON1 levelsVascular endotheliumDisease processEpidemiology studiesClinical biomarkersPopulation riskBiochemical effectsAntioxidant defenseRiskFish consumptionDisease biomarkers
2012
Cadmium Risk Assessment in Relation to Background Risk of Chronic Kidney Disease
Ginsberg GL. Cadmium Risk Assessment in Relation to Background Risk of Chronic Kidney Disease. Journal Of Toxicology And Environmental Health Part A 2012, 75: 374-390. PMID: 22524593, DOI: 10.1080/15287394.2012.670895.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseKidney diseaseU.S. Environmental Protection Agency reference dosesStage 3 chronic kidney diseaseNoncancer effectsPopulation riskCurrent dietary exposureMinimum risk levelLower Cd doseCKD riskDisease Registry's Minimum Risk LevelDaily doseLow doseChronic daily doseSwedish womenDietary exposureLeft shiftAdverse effectsCd doseDiseaseCadmium risk assessmentDoseReference dosesDose responseGFR
2011
Benzothiazole Toxicity Assessment in Support of Synthetic Turf Field Human Health Risk Assessment
Ginsberg G, Toal B, Kurland T. Benzothiazole Toxicity Assessment in Support of Synthetic Turf Field Human Health Risk Assessment. Journal Of Toxicology And Environmental Health Part A 2011, 74: 1175-1183. PMID: 21797770, DOI: 10.1080/15287394.2011.586943.Peer-Reviewed Original ResearchConceptsHealth risk assessmentSynthetic turf fieldsHuman health risk assessmentSubchronic dietary studyHuman bladder cancerOral slope factorBladder cancerInhalation exposureRoute extrapolationRespiratory irritantsRisk assessmentDermal sensitizerMetabolic activationEffect levelRodent carcinogensChemical exposureToxicology databaseCarcinogenic potentialAcute toxicityGenetic toxicityDietary studiesUnit riskTurf fieldsRiskSlope factorHuman Health Risk Assessment of Synthetic Turf Fields Based Upon Investigation of Five Fields in Connecticut
Ginsberg G, Toal B, Simcox N, Bracker A, Golembiewski B, Kurland T, Hedman C. Human Health Risk Assessment of Synthetic Turf Fields Based Upon Investigation of Five Fields in Connecticut. Journal Of Toxicology And Environmental Health Part A 2011, 74: 1150-1174. PMID: 21797769, DOI: 10.1080/15287394.2011.586942.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAir PollutantsAir Pollution, IndoorAthletesBenzothiazolesCarcinogens, EnvironmentalChildConnecticutElastomersEnvironmental ExposureFacility Design and ConstructionGuidelines as TopicHumansNeoplasmsPlay and PlaythingsPublic FacilitiesRecyclingRespiratory RateRisk AssessmentRisk FactorsSeasonsSports EquipmentConceptsSynthetic turf fieldsGreater ventilationAdverse health risksAcute hazard indexInhalation rateAdequate ventilationSeparate risk assessmentHealth risk assessmentHuman health risk assessmentPossible exposurePotential concernTurf fieldsRisk assessmentHigh exposureExposure concentrationsHealth risksBreathing zoneHazard indexVentilationPersonal samplersExposureAdultsState of ConnecticutChildrenNew York CityDevelopment and evaluation of a harmonized physiologically based pharmacokinetic (PBPK) model for perchloroethylene toxicokinetics in mice, rats, and humans
Chiu WA, Ginsberg GL. Development and evaluation of a harmonized physiologically based pharmacokinetic (PBPK) model for perchloroethylene toxicokinetics in mice, rats, and humans. Toxicology And Applied Pharmacology 2011, 253: 203-234. PMID: 21466818, DOI: 10.1016/j.taap.2011.03.020.Peer-Reviewed Original ResearchPolymorphism in the DNA repair enzyme XRCC1: Utility of current database and implications for human health risk assessment
Ginsberg G, Angle K, Guyton K, Sonawane B. Polymorphism in the DNA repair enzyme XRCC1: Utility of current database and implications for human health risk assessment. Mutation Research/Fundamental And Molecular Mechanisms Of Mutagenesis 2011, 727: 1-15. PMID: 21352951, DOI: 10.1016/j.mrrev.2011.02.001.Peer-Reviewed Original ResearchConceptsBase excision repairDNA repairGene expressionRepair functionUpstream regulatory sequencesDNA damaging agentsHomozygous variantToxicodynamic responseXRCC1 levelsRegulatory sequencesBinding sequenceExcision repairDamaging agentsProtein structureBER genesDNA damageAllele frequenciesCurrent databasePolymorphismGenotype effectsArg399Gln variantPhenotypeGenetic polymorphismsXRCC1Environmental agents
2000
Development of a single-meal fish consumption advisory for methyl mercury.
Ginsberg G, Toal B. Development of a single-meal fish consumption advisory for methyl mercury. Risk Analysis 2000, 20: 41-7. PMID: 10795337, DOI: 10.1111/0272-4332.00004.Peer-Reviewed Original ResearchConceptsFish consumption advisoriesMaternal hair concentrationsConsumption advisoriesMethyl mercuryHair concentrationsU.S. Environmental Protection Agency reference doseEnvironmental Protection Agency reference doseFish MeHg concentrationsMercury hair concentrationFish tissue concentrationsMeHg body burdenAcute exposure to MeHgContamination of fishExposure to MeHgFish sampling programSingle-meal scenariosMeHg concentrationsRfD levelFish concentrationsBody burdenFish consumptionReference doseMeHgSampling programSeasonal differences