2013
Renalase protects against cisplatin acute kidney injury in mice
Desir G, Wang L, Velazquez H, Moeckel G, Safirstein R. Renalase protects against cisplatin acute kidney injury in mice. The FASEB Journal 2013, 27: 910.7-910.7. DOI: 10.1096/fasebj.27.1_supplement.910.7.Peer-Reviewed Original ResearchCisplatin acute kidney injuryAcute kidney injuryRenalase expressionKidney injuryCisplatin-induced acute kidney injuryIschemic acute kidney injuryRenal injury scoreUseful therapeutic optionHK-2 cellsImportant clinical syndromeRenalase deficiencyTubular necrosisPro-survival signalsTherapeutic optionsClinical syndromeInjury scorePlasma creatinineKO miceEffective therapyRenalaseBCL2 expressionMarked reductionProtective actionCaspase-3InjuryRenalase Protects against Ischemic AKI
Lee HT, Kim JY, Kim M, Wang P, Tang L, Baroni S, D’Agati V, Desir GV. Renalase Protects against Ischemic AKI. Journal Of The American Society Of Nephrology 2013, 24: 445-455. PMID: 23393318, PMCID: PMC3582209, DOI: 10.1681/asn.2012090943.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdrenergic alpha-AntagonistsAnimalsApoptosisGene ExpressionHumansInflammation MediatorsIschemiaKidney Tubular Necrosis, AcuteMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutMonoamine OxidaseNeutrophil InfiltrationNorepinephrinePhentolamineRecombinant ProteinsReperfusion InjuryRNA, MessengerConceptsRenal ischemia-reperfusion injuryIschemia-reperfusion injuryIschemic AKIWild-type miceReperfusion injuryCatecholamine levelsRenal tubular inflammationTreatment of AKIRenal ischemia reperfusionSham-operated micePlasma catecholamine levelsRenal tubular necrosisRecombinant human renalasePlasma renalaseTubular inflammationTubular necrosisIschemia reperfusionNE levelsPlasma catecholaminesMyocardial necrosisInflammatory responseProximal tubulesAKIRenalaseMice
1990
The Clinical Utility of Indium-111 Labeled Platelet Scintigraphy in the Diagnoses of Renal Transplant Rejection
Desir G, Bia M, Lange R, Smith E, Flye W, Kashgarian M, Schiff M, Ezekowitz M. The Clinical Utility of Indium-111 Labeled Platelet Scintigraphy in the Diagnoses of Renal Transplant Rejection. Developments In Nuclear Medicine 1990, 264-277. DOI: 10.1007/978-94-009-0581-8_24.Peer-Reviewed Original ResearchAcute rejectionPost-operative acute tubular necrosisDiagnostic biochemical parametersAcute tubular necrosisKidney transplant recipientsRenal transplant rejectionNon-invasive testsGraft functionGraft painGraft survivalTransplant recipientsAllograft rejectionRenal damageSerum creatinineTubular necrosisKidney biopsyMajor complicationsUrine outputClinical groundsClinical parametersTransplant rejectionPlatelet scintigraphyEarly treatmentInvasive testsClinical utility