Catecholamines Regulate the Activity, Secretion, and Synthesis of Renalase
Li G, Xu J, Wang P, Velazquez H, Li Y, Wu Y, Desir GV. Catecholamines Regulate the Activity, Secretion, and Synthesis of Renalase. Circulation 2008, 117: 1277-1282. PMID: 18299506, DOI: 10.1161/circulationaha.107.732032.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseKidney diseaseExcess catecholaminesPlasma renalase concentrationSystolic pressure increaseSympathetic nervous systemRenalase gene expressionRegulation of catecholaminesAttractive therapeutic modalityRenalase concentrationCatecholamine surgeBlood pressureNormotensive ratsCatecholamine levelsHemodynamic changesPlasma levelsRecombinant renalaseSystemic abnormalitiesRenalase activityCardiac contractilityTherapeutic modalitiesCardiac hypertrophyCatecholamine metabolismHeart rateParenteral administration