2024
Predictive modeling of gene mutations for the survival outcomes of epithelial ovarian cancer patients
C. M, Lavi E, Altwerger G, Lin Z, Ratner E. Predictive modeling of gene mutations for the survival outcomes of epithelial ovarian cancer patients. PLOS ONE 2024, 19: e0305273. PMID: 38976671, PMCID: PMC11230535, DOI: 10.1371/journal.pone.0305273.Peer-Reviewed Original ResearchConceptsEpithelial ovarian cancerEpithelial ovarian cancer patientsEpithelial ovarian cancer casesGene mutation signaturesPlatinum-based chemotherapyThe Cancer Genome AtlasResponse to treatmentOverall survivalGene mutationsMutational signaturesHomologous recombinationSurvival outcomesIncreased sensitivity to platinum-based chemotherapySensitivity to platinum-based chemotherapyAssociated with increased chemoresistanceResistance to platinum-based chemotherapySurvival timeSurvival rateFavorable response to treatmentPlatinum-induced DNA damageKaplan-Meier survival analysisPrediction of survival outcomesOvarian cancer patientsOverall survival ratePrediction of treatment outcome
2023
Surgical and oncologic outcomes in surgically treated women 80 years and older with endometrioid endometrial cancer as a function of their comorbidities
AlAshqar A, Ghazarian M, Webster E, Upadhyay A, Azodi M, Schwartz P, Ratner E, Altwerger G. Surgical and oncologic outcomes in surgically treated women 80 years and older with endometrioid endometrial cancer as a function of their comorbidities. Gynecologic Oncology Reports 2023, 49: 101240. PMID: 37636496, PMCID: PMC10450407, DOI: 10.1016/j.gore.2023.101240.Peer-Reviewed Original ResearchEndometrioid endometrial cancerOldest-old womenOncologic outcomesEndometrial cancerOlder womenComorbidity statusEarly-stage endometrioid endometrial cancerKaplan-Meier survival analysisLymph node dissectionRetrospective cohort studyFive-year survivalTimes higher riskCounseling of patientsComorbidity burdenPreoperative optimizationComorbidity indexNode dissectionCohort studyIndependent predictorsMedian agePostoperative infectionSurgical treatmentRisk diseaseSurgical managementWomen 80