2006
Alcohol-related seizures
Rathlev NK, Ulrich AS, Delanty N, D’Onofrio G. Alcohol-related seizures. Journal Of Emergency Medicine 2006, 31: 157-163. PMID: 17044577, DOI: 10.1016/j.jemermed.2005.09.012.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol Withdrawal SeizuresAnticonvulsantsBenzodiazepinesBrainDiagnostic ImagingHumansRisk FactorsConceptsAlcohol-related seizuresDiagnostic evaluationAdult-onset seizuresPre-existing epilepsyCause of seizuresStructural brain lesionsThorough diagnostic evaluationDevelopment of seizuresConcurrent risk factorsChronic alcohol dependenceHigh-risk periodNew onsetAlcohol withdrawalStatus epilepticusFocal seizuresSeizure activityRisk factorsCurrent seizuresBrain lesionsSeizuresPatientsAlcohol dependenceEpilepticusIllicit drugsCurrent literature
2000
Clinical Characteristics as Predictors of Recurrent Alcohol‐related Seizures
Rathlev N, Ulrich A, Fish S, D'Onofrio G. Clinical Characteristics as Predictors of Recurrent Alcohol‐related Seizures. Academic Emergency Medicine 2000, 7: 886-891. PMID: 10958128, DOI: 10.1111/j.1553-2712.2000.tb02066.x.Peer-Reviewed Original ResearchConceptsAlcohol-related seizuresClinical characteristicsBlood pressureEthanol levelsRecurrent seizuresLower riskLower-risk clinical characteristicsPlacebo-treated patientsDiastolic blood pressureSubset of patientsSystolic blood pressureRetrospective secondary analysisDaily ethanol consumptionRecurrent alcoholPlacebo armRandomized trialsPrevious seizuresEmergency departmentEthanol abuseClinical dataDrug treatmentHeart rateEthanol consumptionSeizuresRespiratory rate
1999
Lorazepam for the Prevention of Recurrent Seizures Related to Alcohol
D'Onofrio G, Rathlev N, Ulrich A, Fish S, Freedland E. Lorazepam for the Prevention of Recurrent Seizures Related to Alcohol. New England Journal Of Medicine 1999, 340: 915-919. PMID: 10094637, DOI: 10.1056/nejm199903253401203.Peer-Reviewed Original ResearchConceptsPlacebo groupRecurrent seizuresSecond seizureLorazepam groupEmergency departmentNormal salineAlcohol abusePrimary end pointDouble-blind studyChronic alcohol abuseYears of ageIntravenous lorazepamHospital dischargeConsecutive patientsGeneralized seizuresEntry criteriaCommon causePatientsSeizuresEnd pointLorazepamObservation periodSignificant reductionHospitalSaline