2022
Natural history of bicuspid aortic valves and ascending aortic aneurysms: Aortic center experience
Bellaire CP, Tharakan SM, Roy J, Puskas JD, Di Luozzo G. Natural history of bicuspid aortic valves and ascending aortic aneurysms: Aortic center experience. Journal Of Cardiac Surgery 2022, 37: 2326-2335. PMID: 35535018, DOI: 10.1111/jocs.16597.Peer-Reviewed Original ResearchConceptsBicuspid aortic valveAdverse event ratesTAV patientsEntire cohortAortic aneurysmAortic valveComputerized tomographyLow adverse event ratesOverall adverse event rateNatural historyEvent ratesTricuspid aortic valve patientsValve typeRoutine computerized tomographyMore CT scansAortic valve patientsCoronary artery diseaseMean aneurysm sizeAneurysm growth rateAortic valve typeSimilar natural historyAortic eventsConservative managementSmoking historyUnmatched cohortSpinal cord protection in open and endovascular approaches to thoracoabdominal aortic aneurysms
Amabile A, Lewis E, Costa V, Tadros RO, Han DK, Di Luozzo G. Spinal cord protection in open and endovascular approaches to thoracoabdominal aortic aneurysms. Vascular 2022, 31: 874-883. PMID: 35507464, DOI: 10.1177/17085381221094411.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCord injuryAortic aneurysmSpinal cordDistal aortic perfusionSubclavian artery revascularizationSpinal cord protectionThoracoabdominal aortic aneurysmsCerebrospinal fluid drainageThoracic aortic aneurysmArtery revascularizationAortic repairEndovascular repairAortic perfusionAortic proceduresEndovascular approachSystemic hypothermiaPostoperative managementExtracorporeal circulationLocal edemaPersistent complicationsFluid drainageCurrent evidenceInjuryAdjunct
2019
Paraspinous muscle gene expression profiling following simulated staged endovascular repair of thoracoabdominal aortic aneurysm: exploring potential therapeutic pathways
Lewis ER, Geisbüsch S, Chang YJ, Costa V, Husain S, Soteropoulos P, Griepp RB, Di Luozzo G. Paraspinous muscle gene expression profiling following simulated staged endovascular repair of thoracoabdominal aortic aneurysm: exploring potential therapeutic pathways. European Journal Of Cardio-Thoracic Surgery 2019, 57: 30-38. PMID: 31006003, DOI: 10.1093/ejcts/ezz113.Peer-Reviewed Original ResearchConceptsAneurysm repairGene expression profilingCollateral networkThoracoabdominal aortic aneurysm repairSpinal collateral networkSpinal segmental arteriesSuch extensive proceduresThoracoabdominal aortic aneurysmsAortic aneurysm repairSpinal cord perfusionSpinal cord injuryPotential therapeutic pathwayExpression profilingArteriolar remodellingTAAA repairCord perfusionNeurological complicationsEndovascular repairNeuroprotective effectsEndovascular techniquesCord injuryAortic aneurysmCoil embolizationEndovascular coilingEndovascular intervention
2016
Planned Staged Repair of Thoracoabdominal Aortic Aneurysms to Minimize Spinal Cord Injury: A Proof of Concept
Di Luozzo G, Wilderman M, Pawale A, McCullough J, Griepp R. Planned Staged Repair of Thoracoabdominal Aortic Aneurysms to Minimize Spinal Cord Injury: A Proof of Concept. Aorta 2016, 3: 177-180. DOI: 10.12945/j.aorta.2016.15.003.Peer-Reviewed Original Research
2015
LONG-TERM SURVIVAL AND FOLLOW-UP IN PATIENTS WITH CONNECTIVE TISSUE DISORDERS UNDERGOING EXTENSIVE OPEN REPAIRS OF THORACOABDOMINAL AORTIC ANEURYSMS
Di Luozzo G, Lewis E, Geisbuesch S, Nyirenda T, Weiss A, Pawale A, Griepp R, Spielvogel D. LONG-TERM SURVIVAL AND FOLLOW-UP IN PATIENTS WITH CONNECTIVE TISSUE DISORDERS UNDERGOING EXTENSIVE OPEN REPAIRS OF THORACOABDOMINAL AORTIC ANEURYSMS. Journal Of The American College Of Cardiology 2015, 65: a2114. DOI: 10.1016/s0735-1097(15)62114-3.Peer-Reviewed Original Research
2013
A prospective study of growth and rupture risk of small-to-moderate size ascending aortic aneurysms
Geisbüsch S, Stefanovic A, Schray D, Oyfe I, Lin HM, Di Luozzo G, Griepp RB. A prospective study of growth and rupture risk of small-to-moderate size ascending aortic aneurysms. Journal Of Thoracic And Cardiovascular Surgery 2013, 147: 68-74. PMID: 23953716, DOI: 10.1016/j.jtcvs.2013.06.030.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnticoagulantsAortaAortic AneurysmAortic RuptureAortographyCase-Control StudiesChi-Square DistributionDisease ProgressionFemaleFibrinolytic AgentsHumansLeast-Squares AnalysisLinear ModelsMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesRisk AssessmentRisk FactorsTime FactorsTomography, X-Ray ComputedVascular Surgical ProceduresConceptsTotal aortic volumeAscending Aortic AneurysmAortic aneurysmAortic volumeModerate size aneurysmsReference groupML/yearAntithrombotic medicationAortic pathologySurgical indicationsUnderwent operationAortic sizeProspective studyEmergency departmentAortic growthSurveillance groupLarge aneurysmsRisk factorsSinotubular junctionTomography scanTomography volume measurementsDissection riskPatientsCompelling indicationsAneurysmsHypothermia for aortic surgery
Griepp RB, Di Luozzo G. Hypothermia for aortic surgery. Journal Of Thoracic And Cardiovascular Surgery 2013, 145: s56-s58. PMID: 23410782, DOI: 10.1016/j.jtcvs.2012.11.072.Peer-Reviewed Original ResearchConceptsHypothermic circulatory arrestCirculatory arrestAcceptable neurologic outcomesAortic arch repairThoracoabdominal aortic aneurysmsAortic surgeryNeurologic outcomeArch repairSurgical patientsBrain metabolismOrgan protectionAortic aneurysmDeep hypothermiaClinical practicePig modelRoutine useHypothermiaArrestRepairPatientsSurgeryAneurysmsPerfusion
2012
Imaging of vascular remodeling after simulated thoracoabdominal aneurysm repair
Geisbüsch S, Schray D, Bischoff MS, Lin HM, Griepp RB, Di Luozzo G. Imaging of vascular remodeling after simulated thoracoabdominal aneurysm repair. Journal Of Thoracic And Cardiovascular Surgery 2012, 144: 1471-1478. PMID: 23010582, PMCID: PMC3496032, DOI: 10.1016/j.jtcvs.2012.08.062.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortic Aneurysm, ThoracicArteriesBarium SulfateBehavior, AnimalCollateral CirculationContrast MediaDilatation, PathologicDisease Models, AnimalFemaleLatexLigationMammary ArteriesMultidetector Computed TomographyNeovascularization, PhysiologicParaplegiaReplica TechniquesSpinal CordSpinal Cord IschemiaSwineTime FactorsVascular Surgical ProceduresConceptsAnterior spinal arterySpinal cord blood supplySmall collateral vesselsAneurysm repairCollateral vesselsBlood supplyJuvenile Yorkshire pigsRisk of paraplegiaThoracoabdominal aneurysm repairThoracoabdominal aortic aneurysmsSpinal cord circulationEndovascular repairSpinal arteryArtery sacrificeIntercostal arteriesCord circulationInternal thoracicAortic aneurysmTomographic scanTomographic scanningVascular remodelingGroup 2Group 1Group 3Previous interventionsOpen Repair of Descending and Thoracoabdominal Aortic Aneurysms and Dissections in Patients Aged Younger Than 60 Years: Superior to Endovascular Repair?
Di Luozzo G, Geisbüsch S, Lin HM, Bischoff MS, Schray D, Pawale A, Griepp RB. Open Repair of Descending and Thoracoabdominal Aortic Aneurysms and Dissections in Patients Aged Younger Than 60 Years: Superior to Endovascular Repair? The Annals Of Thoracic Surgery 2012, 95: 12-19. PMID: 22785215, DOI: 10.1016/j.athoracsur.2012.05.071.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAortic Aneurysm, ThoracicAortic DissectionBlood Vessel Prosthesis ImplantationCirculatory Arrest, Deep Hypothermia InducedFemaleFollow-Up StudiesHospital MortalityHumansMaleMiddle AgedNew YorkRetrospective StudiesStentsSurvival RateTime FactorsTreatment OutcomeYoung AdultConceptsThoracoabdominal aortic aneurysmsEndovascular repairOpen repairStent graftingAortic aneurysmDeep hypothermic circulatory arrestPrevious aortic operationHypothermic circulatory arrestOpen surgical repairNeurologic complication rateCerebrospinal fluid drainageModality of choiceChronic dissectionAcute dissectionAortic complicationsAortic operationsDiversity of patientsYounger patientsCirculatory arrestCommon indicationComplication rateNeurologic monitoringSurgical repairEarly mortalityLinearized rate
2010
Experimental Basis and Clinical Studies of Brain Protection in Aortic Arch Surgery
Di Luozzo G, Griepp R. Experimental Basis and Clinical Studies of Brain Protection in Aortic Arch Surgery. 2010, 219-228. DOI: 10.1007/978-1-84996-293-3_18.Peer-Reviewed Original ResearchBrain protection strategiesHypothermic circulatory arrestBrain protectionComplex aortic arch diseaseAntegrade brain perfusionAortic arch surgeryAortic arch diseasePediatric cardiac surgeonsArch diseaseArch surgeryCirculatory arrestBrain metabolismAortic aneurysmAortic archBrain perfusionSurgical techniqueClinical studiesCardiac surgeonsClinical practiceResectionSurgeryAneurysmsHypothermiaCommon denominatorPerfusionPredicting the Risk of Paraplegia After Thoracic and Thoracoabdominal Aneurysm Repair
Zoli S, Roder F, Etz CD, Brenner RM, Bodian CA, Lin HM, Di Luozzo G, Griepp RB. Predicting the Risk of Paraplegia After Thoracic and Thoracoabdominal Aneurysm Repair. The Annals Of Thoracic Surgery 2010, 90: 1237-1245. PMID: 20868820, DOI: 10.1016/j.athoracsur.2010.04.091.Peer-Reviewed Original ResearchConceptsSpinal cord injuryRisk of paraplegiaSegmental arteriesParaplegia riskEndovascular repairAneurysm repairCord injuryThoracoabdominal aortic aneurysm repairMotor-evoked potential monitoringPrevious aortic surgeryThoracoabdominal aneurysm repairIndependent risk factorThoracoabdominal aortic aneurysmsAortic aneurysm repairStandard surgical approachCerebrospinal fluid drainageCrawford classificationHospital mortalitySCI riskAortic surgeryEmergent operationSurgical approachAortic aneurysmRisk factorsAbdominal aortaStaged repair significantly reduces paraplegia rate after extensive thoracoabdominal aortic aneurysm repair
Etz CD, Zoli S, Mueller CS, Bodian CA, Di Luozzo G, Lazala R, Plestis KA, Griepp RB. Staged repair significantly reduces paraplegia rate after extensive thoracoabdominal aortic aneurysm repair. Journal Of Thoracic And Cardiovascular Surgery 2010, 139: 1464-1472. PMID: 20494193, DOI: 10.1016/j.jtcvs.2010.02.037.Peer-Reviewed Original ResearchConceptsExtensive thoracoabdominal aortic aneurysm repairExtensive segmental artery sacrificeThoracoabdominal aortic aneurysm repairThoracoabdominal aortic aneurysmsAortic aneurysm repairSpinal cord injuryArtery sacrificeAneurysm repairCord injuryAortic aneurysmCrawford type II thoracoabdominal aortic aneurysmType II thoracoabdominal aortic aneurysmIschemic spinal cord damageChronic obstructive pulmonary diseasePermanent spinal cord injuryExtensive thoracoabdominal aortic aneurysmsCrawford type ICrawford type IIIOverall hospital mortalityPrevious cerebrovascular accidentYear of procedureHypothermic circulatory arrestObstructive pulmonary diseaseOpen surgical repairMotor-evoked potentials
2009
Aortic Arch Resection and Ligation of the Descending Thoracic Aorta to Manage a Ruptured Thoracoabdominal Aneurysm
Weiss A, Di Luozzo G, Etz CD, Griepp RB. Aortic Arch Resection and Ligation of the Descending Thoracic Aorta to Manage a Ruptured Thoracoabdominal Aneurysm. Vascular And Endovascular Surgery 2009, 43: 614-616. PMID: 19640920, DOI: 10.1177/1538574409335273.Peer-Reviewed Original ResearchConceptsThoracoabdominal aortic aneurysmsAcute type B aortic dissectionType B aortic dissectionAortic arch resectionRuptured thoracoabdominal aneurysmHigh-risk patientsOpen surgical interventionOpen surgical repairB aortic dissectionThoracoabdominal aneurysmsAortic dissectionAortic ruptureEndovascular approachSurgical repairArch resectionSurgical interventionAortic aneurysmThoracic aortaPrimary operationPatientsAneurysmsLess conventional approachesRuptureReoperationResectionDirect Spinal Cord Perfusion Pressure Monitoring in Extensive Distal Aortic Aneurysm Repair
Etz CD, Di Luozzo G, Zoli S, Lazala R, Plestis KA, Bodian CA, Griepp RB. Direct Spinal Cord Perfusion Pressure Monitoring in Extensive Distal Aortic Aneurysm Repair. The Annals Of Thoracic Surgery 2009, 87: 1764-1774. PMID: 19463592, DOI: 10.1016/j.athoracsur.2009.02.101.Peer-Reviewed Original ResearchConceptsSpinal cord perfusion pressureDeep hypothermic circulatory arrestThoracoabdominal aortic aneurysmsAortic aneurysm repairHypothermic circulatory arrestNonpulsatile cardiopulmonary bypassCardiopulmonary bypassPerfusion pressureSegmental arteriesEndovascular repairAneurysm repairCirculatory arrestAortic aneurysmThoracoabdominal aortic aneurysm repairNormal spinal cord functionPerfusion pressure monitoringThoracic segmental arteriesMean arterial pressureSpinal cord functionSpinal cord recoveryParaspinal collateral networkArterial pressureCord functionCollateral networkPressure monitoring