2011
Diffusion Tensor Imaging in Autism Spectrum Disorders: Preliminary Evidence of Abnormal Neural Connectivity
Jou RJ, Jackowski AP, Papademetris X, Rajeevan N, Staib LH, Volkmar FR. Diffusion Tensor Imaging in Autism Spectrum Disorders: Preliminary Evidence of Abnormal Neural Connectivity. Australian & New Zealand Journal Of Psychiatry 2011, 45: 153-162. PMID: 21128874, PMCID: PMC3123660, DOI: 10.3109/00048674.2010.534069.Peer-Reviewed Original Research
2010
Functional impact of global rare copy number variation in autism spectrum disorders
Pinto D, Pagnamenta AT, Klei L, Anney R, Merico D, Regan R, Conroy J, Magalhaes TR, Correia C, Abrahams BS, Almeida J, Bacchelli E, Bader GD, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bölte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Bryson SE, Carson AR, Casallo G, Casey J, Chung BH, Cochrane L, Corsello C, Crawford EL, Crossett A, Cytrynbaum C, Dawson G, de Jonge M, Delorme R, Drmic I, Duketis E, Duque F, Estes A, Farrar P, Fernandez BA, Folstein SE, Fombonne E, Freitag CM, Gilbert J, Gillberg C, Glessner JT, Goldberg J, Green A, Green J, Guter SJ, Hakonarson H, Heron EA, Hill M, Holt R, Howe JL, Hughes G, Hus V, Igliozzi R, Kim C, Klauck SM, Kolevzon A, Korvatska O, Kustanovich V, Lajonchere CM, Lamb JA, Laskawiec M, Leboyer M, Le Couteur A, Leventhal BL, Lionel AC, Liu XQ, Lord C, Lotspeich L, Lund SC, Maestrini E, Mahoney W, Mantoulan C, Marshall CR, McConachie H, McDougle CJ, McGrath J, McMahon WM, Merikangas A, Migita O, Minshew NJ, Mirza GK, Munson J, Nelson SF, Noakes C, Noor A, Nygren G, Oliveira G, Papanikolaou K, Parr JR, Parrini B, Paton T, Pickles A, Pilorge M, Piven J, Ponting CP, Posey DJ, Poustka A, Poustka F, Prasad A, Ragoussis J, Renshaw K, Rickaby J, Roberts W, Roeder K, Roge B, Rutter ML, Bierut LJ, Rice JP, Salt J, Sansom K, Sato D, Segurado R, Sequeira AF, Senman L, Shah N, Sheffield VC, Soorya L, Sousa I, Stein O, Sykes N, Stoppioni V, Strawbridge C, Tancredi R, Tansey K, Thiruvahindrapduram B, Thompson AP, Thomson S, Tryfon A, Tsiantis J, Van Engeland H, Vincent JB, Volkmar F, Wallace S, Wang K, Wang Z, Wassink TH, Webber C, Weksberg R, Wing K, Wittemeyer K, Wood S, Wu J, Yaspan BL, Zurawiecki D, Zwaigenbaum L, Buxbaum JD, Cantor RM, Cook EH, Coon H, Cuccaro ML, Devlin B, Ennis S, Gallagher L, Geschwind DH, Gill M, Haines JL, Hallmayer J, Miller J, Monaco AP, Nurnberger Jr J, Paterson AD, Pericak-Vance MA, Schellenberg GD, Szatmari P, Vicente AM, Vieland VJ, Wijsman EM, Scherer SW, Sutcliffe JS, Betancur C. Functional impact of global rare copy number variation in autism spectrum disorders. Nature 2010, 466: 368-372. PMID: 20531469, PMCID: PMC3021798, DOI: 10.1038/nature09146.Peer-Reviewed Original ResearchConceptsUnderlying genetic determinantsRare copy number variationsCopy number variationsNovel genesWide analysisIndividual genomesASD candidatesCopy numberNumber variationsGenetic determinantsCellular proliferationFunctional impactDe novoGenomeGenesGeneticsDNAPathwayNovoMotilityProliferationAutism spectrum disorderLimited Attentional Bias for Faces in Toddlers With Autism Spectrum Disorders
Chawarska K, Volkmar F, Klin A. Limited Attentional Bias for Faces in Toddlers With Autism Spectrum Disorders. JAMA Psychiatry 2010, 67: 178-185. PMID: 20124117, PMCID: PMC4871149, DOI: 10.1001/archgenpsychiatry.2009.194.Peer-Reviewed Original ResearchConceptsAttention disengagementVisual attentionRelevant stimuliDeep processingFace-processing difficultiesPoor face recognitionFace processing deficitsDisengagement of attentionCentral fixation stimulusAutism spectrum disorderSaccadic reaction timesBetween-groups factorAttentional biasSocial cognitionAttention taskAttentional mechanismsNonfacial stimuliAttentional levelStimulus typeSpectrum disorderTypical individualsReactive saccadesFixation stimulusASDGeneralized impairment
2009
A genome-wide linkage and association scan reveals novel loci for autism
Daly M, Chakravarti A, Arking D, Brune C, West K, O’Connor A, Hilton G, Tomlinson R, West A, Cook Jr E, Chakravarti A, Weiss L, Green T, Chang S, Gabriel S, Gates C, Hanson E, Kirby A, Korn J, Kuruvilla F, McCarroll S, Morrow E, Neale B, Purcell S, Sasanfar R, Sougnez C, Stevens C, Altshuler D, Gusella J, Santangelo S, Sklar P, Tanzi R, Daly M, Anney R, Bailey A, Baird G, Battaglia A, Berney T, Betancur C, Bölte S, Bolton P, Brian J, Bryson S, Buxbaum J, Cabrito I, Cai G, Cantor R, Cook Jr E, Coon H, Conroy J, Correia C, Corsello C, Crawford E, Cuccaro M, Dawson G, de Jonge M, Devlin B, Duketis E, Ennis S, Estes A, Farrar P, Fombonne E, Freitag C, Gallagher L, Geschwind D, Gilbert J, Gill M, Gillberg C, Goldberg J, Green A, Green J, Guter S, Haines J, Hallmayer J, Hus V, Klauck S, Korvatska O, Lamb J, Laskawiec M, Leboyer M, Le Couteur A, Leventhal B, Liu X, Lord C, Lotspeich L, Maestrini E, Magalhaes T, Mahoney W, Mantoulan C, McConachie H, McDougle C, McMahon W, Marshall C, Miller J, Minshew N, Monaco A, Munson J, Nurnberger Jr J, Oliveira G, Pagnamenta A, Papanikolaou K, Parr J, Paterson A, Pericak-Vance M, Pickles A, Pinto D, Piven J, Posey D, Poustka A, Poustka F, Regan R, Reichert J, Renshaw K, Roberts W, Roge B, Rutter M, Salt J, Schellenberg G, Scherer S, Sheffield V, Sutcliffe J, Szatmari P, Tansey K, Thompson A, Tsiantis J, Van Engeland H, Vicente A, Vieland V, Volkmar F, Wallace S, Wassink T, Wijsman E, Wing K, Wittemeyer K, Yaspan B, Zwaigenbaum L, Morrow E, Yoo S, Sean Hill R, Mukaddes N, Balkhy S, Gascon G, Al-Saad S, Hashmi A, Ware J, Joseph R, LeClair E, Partlow J, Barry B, Walsh C, Pauls D, Moilanen I, Ebeling H, Mattila M, Kuusikko S, Jussila K, Ignatius J, Sasanfar R, Tolouei A, Ghadami M, Rostami M, Hosseinipour A, Valujerdi M, Santangelo S, Andresen K, Winkloski B, Haddad S, Kunkel L, Kohane Z, Tran T, Won Kong S, O’Neil S, Hanson E, Hundley R, Holm I, Peters H, Baroni E, Cangialose A, Jackson L, Albers L, Becker R, Bridgemohan C, Friedman S, Munir K, Nazir R, Palfrey J, Schonwald A, Simmons E, Rappaport L, Gauthier J, Mottron L, Joober R, Fombonne E, Rouleau G, Rehnstrom K, von Wendt L, Peltonen L. A genome-wide linkage and association scan reveals novel loci for autism. Nature 2009, 461: 802-808. PMID: 19812673, PMCID: PMC2772655, DOI: 10.1038/nature08490.Peer-Reviewed Original ResearchConceptsGenome-wide SNPsSusceptibility genesGenome-wide linkageGenome-wide scanSpecific susceptibility genesAutism susceptibility genesExpression of SEMA5AHeritable neurodevelopmental disorderAssociation scanNovel lociChromosome 5p15Multiplex autism familiesLinkage regionAutism familiesSignificant linkageNovel associationsGenesSEMA5ARare variationNeurodevelopmental disordersCommon setLociSNPsExpressionTAS2R1Social Skills Interventions for Individuals with Autism: Evaluation for Evidence-Based Practices within a Best Evidence Synthesis Framework
Reichow B, Volkmar FR. Social Skills Interventions for Individuals with Autism: Evaluation for Evidence-Based Practices within a Best Evidence Synthesis Framework. Journal Of Autism And Developmental Disorders 2009, 40: 149-166. PMID: 19655240, DOI: 10.1007/s10803-009-0842-0.Peer-Reviewed Original Research
2002
Editorial Preface
Volkmar F. Editorial Preface. Journal Of Autism And Developmental Disorders 2002, 32: 1-1. PMID: 11916336, DOI: 10.1023/a:1017954721441.Peer-Reviewed Original Research
2001
Methodological Issues in Designing a Multisite Trial of Risperidone in Children and Adolescents with Autism
Scahill L, McCracken J, McDougle C, Aman M, Arnold L, Tierney E, Cronin P, Davies M, Ghuman J, Gonzalez N, Koenig K, Lindsay R, Martin A, McGough J, Posey D, Swiezy N, Volkmar F, Ritz L, Vitiello B. Methodological Issues in Designing a Multisite Trial of Risperidone in Children and Adolescents with Autism. Journal Of Child And Adolescent Psychopharmacology 2001, 11: 377-388. PMID: 11838820, DOI: 10.1089/104454601317261555.Peer-Reviewed Original ResearchConceptsPlacebo-controlled studyPlacebo-controlled discontinuation studyAutistic disorderSafety of risperidoneStudy of RisperidoneStandard pharmacological treatmentSelf-injurious behaviorDiscontinuation studyPharmacological treatmentClinical trialsInclusion criteriaLong-term effectsSevere tantrumsTrial designClinical relevanceClinical practiceLength of trialRisperidoneMultisite trialStudy designContinuous treatmentTrialsTreatment effectsDisordersMaintenance phaseSpeech and Prosody Characteristics of Adolescents and Adults With High-Functioning Autism and Asperger Syndrome
Shriberg L, Paul R, McSweeny J, Klin A, Cohen D, Volkmar F. Speech and Prosody Characteristics of Adolescents and Adults With High-Functioning Autism and Asperger Syndrome. Journal Of Speech Language And Hearing Research 2001, 44: 1097-1115. PMID: 11708530, DOI: 10.1044/1092-4388(2001/087).Peer-Reviewed Original ResearchConceptsHigh functioning autismPervasive developmental disorderAsperger syndromeDevelopmental disordersMale speakersGroups of speakersAffective aspectsTypical speakersProsody characteristicsSocial sourcesDiscourse constraintsSpeakersAutismSpeechUtterancesMore participantsDistortion errorsAge rangeProsodyDisordersAdolescentsFindingsParticipantsPhrasingAdultsDiversity and Challenges of Child Psychiatry
Volkmar F. Diversity and Challenges of Child Psychiatry. American Journal Of Psychiatry 2001, 158: 987-988. PMID: 11431217, DOI: 10.1176/appi.ajp.158.7.987.Peer-Reviewed Original ResearchLanguage regression in childhood.
Shinnar S, Rapin I, Arnold S, Tuchman R, Shulman L, Ballaban-Gil K, Maw M, Deuel R, Volkmar F. Language regression in childhood. Pediatric Neurology 2001, 24: 183-9. PMID: 11301218, DOI: 10.1016/s0887-8994(00)00266-6.Peer-Reviewed Original ResearchMeSH KeywordsBrainChildChild Behavior DisordersChild LanguageChild, PreschoolCognition DisordersElectroencephalographyFemaleHumansInfantLandau-Kleffner SyndromeLanguage DisordersLanguage TestsMagnetic Resonance ImagingMaleProspective StudiesRegression, PsychologySeverity of Illness IndexTomography, Emission-Computed, Single-PhotonVerbal BehaviorConceptsYears of ageLanguage regressionAutistic regressionMajor medical centersMonths of ageClinical characteristicsEpileptic aphasiaSpecialist referralMean ageElectroencephalogram abnormalitiesMedical CenterEarly identificationMost childrenSeizuresMean timeAutistic featuresAgeAutistic behaviorChildrenLanguage functionReferralMonthsRegressionPatientsYears
2000
How unspecified are disorders of children with a pervasive developmental disorder not otherwise specified? A study of social problems in children with PDD-NOS and ADHD
Luteijn E, Serra M, Jackson S, Steenhuis M, Althaus M, Volkmar F, Minderaa R. How unspecified are disorders of children with a pervasive developmental disorder not otherwise specified? A study of social problems in children with PDD-NOS and ADHD. European Child & Adolescent Psychiatry 2000, 9: 168-179. PMID: 11095039, DOI: 10.1007/s007870070040.Peer-Reviewed Original ResearchPractice parameter: Screening and diagnosis of autism Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Child Neurology Society
Filipek P, Accardo P, Ashwal S, Baranek G, Cook E, Dawson G, Gordon B, Gravel J, Johnson C, Kallen R, Levy S, Minshew N, Ozonoff S, Prizant B, Rapin I, Rogers S, Stone W, Teplin S, Tuchman R, Volkmar F. Practice parameter: Screening and diagnosis of autism Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Child Neurology Society. Neurology 2000, 55: 468-479. PMID: 10953176, DOI: 10.1212/wnl.55.4.468.Peer-Reviewed Original ResearchConceptsQuality Standards SubcommitteeRoutine developmental screeningRoutine developmental surveillanceChild Neurology SocietyLate preschool ageIdentification of childrenCommon disorderDevelopmental screeningPractice parametersDevelopmental surveillanceMost young childrenEarly interventionEarly identificationAmerican AcademyYoung childrenChildrenDevelopmental disordersPreschool ageDisordersRiskSpecific recommendationsScreeningAutismPreschool yearsAutism reportThe Children's Social Behavior Questionnaire for Milder Variants of PDD Problems: Evaluation of the Psychometric Characteristics
Luteijn E, Luteijn F, Jackson S, Volkmar F, Minderaa R. The Children's Social Behavior Questionnaire for Milder Variants of PDD Problems: Evaluation of the Psychometric Characteristics. Journal Of Autism And Developmental Disorders 2000, 30: 317-330. PMID: 11039858, DOI: 10.1023/a:1005527300247.Peer-Reviewed Original ResearchConceptsChildren's Social Behavior QuestionnaireSocial Behavior QuestionnaireChild Behavior ChecklistADHD groupAutism Behavior ChecklistPDDNOS groupBehavior ChecklistBehavior QuestionnaireGood psychometric qualitiesSignificant group differencesChild psychiatric disordersAutism groupInsight ScaleInsight problemBehavior problemsPsychometric qualitiesGroup differencesPsychometric characteristicsStereotypical behaviorsHigher scoresLarge sampleRigid behaviorComparison of groupsScale constructionChildrenToward a Developmental Operational Definition of Autism
Gillham J, Carter A, Volkmar F, Sparrow S. Toward a Developmental Operational Definition of Autism. Journal Of Autism And Developmental Disorders 2000, 30: 269-278. PMID: 11039854, DOI: 10.1023/a:1005571115268.Peer-Reviewed Original ResearchConceptsMental ageSocialization scoresChronological ageDevelopmental disordersVineland Adaptive Behavior ScalesLarge normative sampleDaily living skillsAdaptive behavior scoresTraditional diagnostic schemeDiagnosis of autismAdaptive Behavior ScalesAutism groupIntellectual functioningNormative sampleMaladaptive behaviorsChild communicationVineland scoresDevelopmental levelBasis of socializationSerious maladaptive behaviorsLiving skillsStandardized measuresAutismBehavior ScaleAdaptive behaviorBrief Report: Interrater Reliability of Clinical Diagnosis and DSM-IV Criteria for Autistic Disorder: Results of the DSM-IV Autism Field Trial
Klin A, Lang J, Cicchetti D, Volkmar F. Brief Report: Interrater Reliability of Clinical Diagnosis and DSM-IV Criteria for Autistic Disorder: Results of the DSM-IV Autism Field Trial. Journal Of Autism And Developmental Disorders 2000, 30: 163-167. PMID: 10832781, DOI: 10.1023/a:1005415823867.Peer-Reviewed Original ResearchVerbal Bias in Recognition of Facial Emotions in Children with Asperger Syndrome
Grossman J, Klin A, Carter A, Volkmar F. Verbal Bias in Recognition of Facial Emotions in Children with Asperger Syndrome. Journal Of Child Psychology And Psychiatry 2000, 41: 369-379. PMID: 10784084, DOI: 10.1111/1469-7610.00621.Peer-Reviewed Original ResearchConceptsFacial emotionsAsperger syndromeFacial expressionsAffective processing taskVerbal mediationSimple emotionsVerbal labelsVerbal IQAsperger groupVerbal biasNonclinical populationsEmotionsCompensatory strategiesProcessing tasksControl childrenChronological ageChildrenQualitative differencesIQAdolescentsBiasWordsTaskControl groupMediationPDDNOS in DSM-IV.
Volkmar F, Shaffer D, First M. PDDNOS in DSM-IV. Journal Of Autism And Developmental Disorders 2000, 30: 74-5. PMID: 10819126.Peer-Reviewed Original ResearchAspergers Disorder
Volkmar F, Klin A, Schultz R, Rubin E, Bronen R. Aspergers Disorder. American Journal Of Psychiatry 2000, 157: 262-267. PMID: 10671397, DOI: 10.1176/appi.ajp.157.2.262.Peer-Reviewed Educational MaterialsResearch Units on Pediatric Psychopharmacology (Rupp) Autism Network Background and Rationale for an Initial Controlled Study of Risperidone
McDougle C, Scahill L, McCracken J, Aman M, Tierney E, Arnold L, Freeman B, Martin A, McGough J, Cronin P, Posey D, Riddle M, Ritz L, Swiezy N, Vitiello B, Volkmar F, Votolato N, Walson P. Research Units on Pediatric Psychopharmacology (Rupp) Autism Network Background and Rationale for an Initial Controlled Study of Risperidone. Child And Adolescent Psychiatric Clinics Of North America 2000, 9: 201-224. PMID: 10674197, DOI: 10.1016/s1056-4993(18)30142-1.Peer-Reviewed Original ResearchConceptsOpen-label trialDA neuronal systemsSafety of risperidoneStudy of RisperidonePlacebo-controlled studyUse of risperidoneExtrapyramidal side effectsTarget of pharmacotherapyTreatment of childrenImpaired social behaviorLong-term effectivenessPreclinical evidenceReceptor blockadeTypical antipsychoticsControlled StudyFirst drugPathophysiology of autismLower riskShort-term benefitsSide effectsRisperidonePotent effectsSymptoms of autismNeuronal systemsEnhanced efficacy
1999
Lessons from Secretin
Volkmar F. Lessons from Secretin. New England Journal Of Medicine 1999, 341: 1842-1845. PMID: 10588973, DOI: 10.1056/nejm199912093412412.Peer-Reviewed Original Research