1991
Localization of the cystic fibrosis transmembrane conductance regulator in pancreas.
Marino CR, Matovcik LM, Gorelick FS, Cohn JA. Localization of the cystic fibrosis transmembrane conductance regulator in pancreas. Journal Of Clinical Investigation 1991, 88: 712-716. PMID: 1713921, PMCID: PMC295422, DOI: 10.1172/jci115358.Peer-Reviewed Original ResearchConceptsCF transmembrane conductance regulatorCystic fibrosisTransmembrane conductance regulatorCFTR peptidesPancreatic secretory functionDouble-label immunofluorescence studiesConductance regulatorDuct epithelial cellsCystic fibrosis transmembrane conductance regulatorFibrosis transmembrane conductance regulatorPancreatic insufficiencyIntralobular duct cellsSecretory functionHuman pancreasCFTR moleculesChloride transportMonoclonal antibodiesApical domainDuct cellsAntibodiesEpithelial cellsAcinar cellsCFTR proteinImmunofluorescence studiesProtein products
1986
Phytohemagglutinin from red kidney bean (Phaseolus vulgaris) inhibits sodium and chloride absorption in the rabbit ileum
Dobbins J, Laurenson J, Gorelick F, Banwell J. Phytohemagglutinin from red kidney bean (Phaseolus vulgaris) inhibits sodium and chloride absorption in the rabbit ileum. Gastroenterology 1986, 90: 1907-1913. PMID: 3009261, DOI: 10.1016/0016-5085(86)90260-x.Peer-Reviewed Original ResearchConceptsRabbit ileumTissue conductanceCyclic guanosine monophosphateEffects of phytohemagglutininIndicator of absorptionAmino acid absorptionSerosal calciumMucosal levelSerosal additionCyclic adenosine monophosphatePhytohemagglutininControl tissuesChloride absorptionCrypt cellsAcid absorptionIleumRabbit colonDietary lectinsGuanosine monophosphateEpithelial surfaceVillus cellsElectrolyte transportLuminal borderNet NaMucosal solution
1982
Somatostatin Decreases Diarrhea in Patients with the Short-Bowel Syndrome
Dharmsathaphorn K, Gorelick FS, Sherwin RS, Cataland S, Dobbins JW. Somatostatin Decreases Diarrhea in Patients with the Short-Bowel Syndrome. Journal Of Clinical Gastroenterology 1982, 4: 521-524. PMID: 6131090, DOI: 10.1097/00004836-198212000-00008.Peer-Reviewed Original ResearchConceptsShort bowel syndromeCrohn's diseaseStool weightMultiple small bowel resectionsPostprandial glucose levelsSmall bowel resectionAbstract Four patientsFour patientsRefractory diarrheaSomatostatin infusionWatery diarrheaGlucose levelsFecal fatDecrease diarrheaDiarrheaPatientsSomatostatinDiseaseInfusionSyndromeResection