2017
Academic Pancreas Centers of Excellence: Guidance from a multidisciplinary chronic pancreatitis working group at PancreasFest
Sheth SG, Conwell DL, Whitcomb DC, Alsante M, Anderson MA, Barkin J, Brand R, Cote GA, Freedman SD, Gelrud A, Gorelick F, Lee LS, Morgan K, Pandol S, Singh VK, Yadav D, Wilcox CM, Hart PA. Academic Pancreas Centers of Excellence: Guidance from a multidisciplinary chronic pancreatitis working group at PancreasFest. Pancreatology 2017, 17: 419-430. PMID: 28268158, PMCID: PMC5525332, DOI: 10.1016/j.pan.2017.02.015.Peer-Reviewed Original ResearchMeSH KeywordsGuidelines as TopicHumansPancreasPancreatic Function TestsPancreatitis, ChronicPatient Care TeamConceptsChronic pancreatitisPancreas centerManagement of CPDisease-related morbidityProgressive inflammatory diseaseMultidisciplinary managementSurgical treatmentPancreatic functionInflammatory diseasesMedical treatmentGuidance statementsConsensus opinionPancreatitisAcademic physiciansTreatmentWorking GroupLiterature reviewMorbidityGroupEpidemiologyDiseasePhysiciansDiagnosis
2013
Models of Acute and Chronic Pancreatitis
Lerch MM, Gorelick FS. Models of Acute and Chronic Pancreatitis. Gastroenterology 2013, 144: 1180-1193. PMID: 23622127, DOI: 10.1053/j.gastro.2012.12.043.Peer-Reviewed Original ResearchConceptsChronic pancreatitisModels of AcuteInfluence of inflammationAutoimmune chronic pancreatitisChronic ethanol feedingCombination of lipopolysaccharideMechanisms of pathogenesisAcinar cell responsesHuman diseasesPancreatic cancerSevere diseaseRodent modelsEthanol feedingSupraphysiologic concentrationsPancreatitisPancreatitis modelAnimal modelsTherapeutic interventionsCell responsesDiseaseFurther characterizationEarly stagesAcuteInflammationCholecystokinin
2011
The Emerging Role of Smoking in the Development of Pancreatitis
Alexandre M, Pandol SJ, Gorelick FS, Thrower EC. The Emerging Role of Smoking in the Development of Pancreatitis. Pancreatology 2011, 11: 469-474. PMID: 21986098, PMCID: PMC3222114, DOI: 10.1159/000332196.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalDisease ProgressionFemaleHumansMaleNicotinePancreasPancreatitisPancreatitis, ChronicRisk FactorsSmokingTobacco Smoke PollutionConceptsDevelopment of pancreatitisTobacco smokingChronic pancreatitisAcute pancreatitisCigarette smokingPancreatic cancerBACKGROUND/Cigarette smokeElectronic searchSmokingPancreatitisOnly articlesEmerging RolePancreasNicotineOriginal articlesRiskMetabolitesSpecific constituentsPubMedCancerDiseaseDoseProgression
2010
Molecular and cellular mechanisms of pancreatic injury
Thrower EC, Gorelick FS, Husain SZ. Molecular and cellular mechanisms of pancreatic injury. Current Opinion In Gastroenterology 2010, 26: 484-489. PMID: 20651589, PMCID: PMC3023172, DOI: 10.1097/mog.0b013e32833d119e.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisEndoplasmic ReticulumHumansPancreasPancreatitis, Acute NecrotizingPancreatitis, ChronicTrypsinTrypsinogenConceptsPancreatic injuryCellular mechanismsFibroblast growth factor 21Antiapoptotic effectGrowth factor 21Ameliorate injuryEndoplasmic reticulum stressChronic pancreatitisFactor 21Immune cellsExendin-4Endogenous trypsin inhibitorBile acidsDisease severityInjuryPancreatitisCausative factorsSensitizing factorTrypsinogen activationProtein CReticulum stressTrypsinogen mutationsBcl-2Intracellular eventsUpregulation of proteins
2009
New Insights Into the Mechanisms of Pancreatitis
Gaisano HY, Gorelick FS. New Insights Into the Mechanisms of Pancreatitis. Gastroenterology 2009, 136: 2040-2044. PMID: 19379751, DOI: 10.1053/j.gastro.2009.04.023.Peer-Reviewed Original Research
2008
Molecular basis for pancreatitis
Thrower E, Husain S, Gorelick F. Molecular basis for pancreatitis. Current Opinion In Gastroenterology 2008, 24: 580-585. PMID: 19122498, PMCID: PMC3030809, DOI: 10.1097/mog.0b013e32830b10e6.Peer-Reviewed Original ResearchConceptsChronic pancreatitisAcute pancreatitisPain responseAnimal modelsToll-like receptor 4Transient receptor potential vanilloid subtype 1Specific neural receptorsSevere acute pancreatitisBasic science studiesChymotrypsin CShock protein 70Neural receptorsReceptor 4Chronic diseasesPancreatitisAlcohol abuseReceptor 2Subtype 1Potential treatmentPilot studyProtective mechanismAcinar cellsProtein 70Genetic factorsYear findings