2019
CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation
Esteghamat F, Broughton JS, Smith E, Cardone R, Tyagi T, Guerra M, Szabó A, Ugwu N, Mani MV, Azari B, Kayingo G, Chung S, Fathzadeh M, Weiss E, Bender J, Mane S, Lifton RP, Adeniran A, Nathanson MH, Gorelick FS, Hwa J, Sahin-Tóth M, Belfort-DeAguiar R, Kibbey RG, Mani A. CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation. Nature Genetics 2019, 51: 1233-1243. PMID: 31358993, PMCID: PMC6675645, DOI: 10.1038/s41588-019-0470-3.Peer-Reviewed Original ResearchConceptsEarly-onset atherosclerosisMetabolic syndromeMetabolic syndrome traitsWhole-exome sequence analysisAttractive therapeutic targetPlatelet hyperactivationInsulin levelsPlasma insulinPlasma levelsInsulin sensitivityInsulin secretionTherapeutic targetPlatelet activationDisease mechanismsSyndrome traitsAtherosclerosisFunction mutationsSyndromeNovel lossInsulinMutationsSecretion
1997
Serologic Assay for Secretory Component Distinguishes Mechanical from Hepatocellular Cholestasis in Humans
Versland M, Wu G, Gorelick F, Larkin J. Serologic Assay for Secretory Component Distinguishes Mechanical from Hepatocellular Cholestasis in Humans. Digestive Diseases And Sciences 1997, 42: 2246-2253. PMID: 9398802, DOI: 10.1023/a:1018810500006.Peer-Reviewed Original Research
1982
Somatostatin Decreases Diarrhea in Patients with the Short-Bowel Syndrome
Dharmsathaphorn K, Gorelick FS, Sherwin RS, Cataland S, Dobbins JW. Somatostatin Decreases Diarrhea in Patients with the Short-Bowel Syndrome. Journal Of Clinical Gastroenterology 1982, 4: 521-524. PMID: 6131090, DOI: 10.1097/00004836-198212000-00008.Peer-Reviewed Original ResearchConceptsShort bowel syndromeCrohn's diseaseStool weightMultiple small bowel resectionsPostprandial glucose levelsSmall bowel resectionAbstract Four patientsFour patientsRefractory diarrheaSomatostatin infusionWatery diarrheaGlucose levelsFecal fatDecrease diarrheaDiarrheaPatientsSomatostatinDiseaseInfusionSyndromeResectionBiliary tract abnormalities in patients with arteriohepatic dysplasia
Gorelick F, Dobbins J, Burrell M, Riely C. Biliary tract abnormalities in patients with arteriohepatic dysplasia. Digestive Diseases And Sciences 1982, 27: 815-820. PMID: 7105953, DOI: 10.1007/bf01391375.Peer-Reviewed Original ResearchConceptsEndoscopic retrograde cholangiopancreatogramBiliary tract abnormalitiesIntrahepatic ductsTract abnormalitiesArteriohepatic dysplasiaExtrahepatic biliary tract obstructionBiliary tract obstructionTract obstructionExtrahepatic ductsCongenital syndromePatientsFocal areasCholestasisDysplasiaSyndromeAbnormalitiesDuctLatter findingCholangiopancreatogramCirrhosisGallstonesDilatationObstructionSymptoms