2013
Models of Acute and Chronic Pancreatitis
Lerch MM, Gorelick FS. Models of Acute and Chronic Pancreatitis. Gastroenterology 2013, 144: 1180-1193. PMID: 23622127, DOI: 10.1053/j.gastro.2012.12.043.Peer-Reviewed Original ResearchConceptsChronic pancreatitisModels of AcuteInfluence of inflammationAutoimmune chronic pancreatitisChronic ethanol feedingCombination of lipopolysaccharideMechanisms of pathogenesisAcinar cell responsesHuman diseasesPancreatic cancerSevere diseaseRodent modelsEthanol feedingSupraphysiologic concentrationsPancreatitisPancreatitis modelAnimal modelsTherapeutic interventionsCell responsesDiseaseFurther characterizationEarly stagesAcuteInflammationCholecystokinin
2010
Alcohol Abuse, Endoplasmic Reticulum Stress and Pancreatitis
Pandol SJ, Gorelick FS, Gerloff A, Lugea A. Alcohol Abuse, Endoplasmic Reticulum Stress and Pancreatitis. Digestive Diseases 2010, 28: 776-782. PMID: 21525762, PMCID: PMC3211518, DOI: 10.1159/000327212.Peer-Reviewed Original ResearchConceptsX-box binding protein 1Alcohol abuseChronic pancreatitisEthanol feedingUnfolded protein responseER stressSignificant pathological responseAcinar cellsAfrican American ethnicityEndoplasmic reticulum stressPancreatic manifestationAlcoholic pancreatitisAdaptive unfolded protein responseMinority of individualsChronic inflammationMost individualsPathological responseCommon causePancreatic diseaseApparent diseasePancreatitisBinding protein 1Heavy drinkersExocrine pancreasPancreas
2008
Ethanol Exposure Depletes Hepatic Pigment Epithelium-Derived Factor, a Novel Lipid Regulator
Chung C, Shugrue C, Nagar A, Doll JA, Cornwell M, Gattu A, Kolodecik T, Pandol SJ, Gorelick F. Ethanol Exposure Depletes Hepatic Pigment Epithelium-Derived Factor, a Novel Lipid Regulator. Gastroenterology 2008, 136: 331-340.e2. PMID: 18996124, PMCID: PMC2833423, DOI: 10.1053/j.gastro.2008.09.065.Peer-Reviewed Original ResearchConceptsPigment epithelium-derived factorEthanol-induced hepatic steatosisEthanol-induced steatosisMMP-2/9 activityPEDF levelsHepatic steatosisEthanol feedingLoss of PEDFAnimal modelsTriglyceride contentRecombinant pigment epithelium-derived factorNovel lipid regulatorLiver triglyceride contentLiver biopsy specimensEpithelium-derived factorEthanol fed animalsNormal liver samplesAccumulation of lipidsHistologic steatosisBiopsy specimensClinical studiesEthanol exposureHepatocellular carcinomaSteatosisPigment epithelium