2017
Do Animal Models of Acute Pancreatitis Reproduce Human Disease?
Gorelick FS, Lerch MM. Do Animal Models of Acute Pancreatitis Reproduce Human Disease? Cellular And Molecular Gastroenterology And Hepatology 2017, 4: 251-262. PMID: 28752114, PMCID: PMC5518169, DOI: 10.1016/j.jcmgh.2017.05.007.Peer-Reviewed Original ResearchAcute pancreatitisBiological disease mechanismsNonmalignant gastrointestinal diseasesPathophysiological disease mechanismsDisease mechanismsPotential therapeutic targetPaucity of dataHospital admissionCommon causeExperimental pancreatitis modelGastrointestinal diseasesPancreatitis modelTherapeutic targetAnimal modelsNatural historySpecific causesDiseaseDisease modelsPancreatitisDisease developmentUnderlying cellMolecular mechanismsHuman diseasesCauseLimited information
2011
Investigating the Pathobiology of Alcoholic Pancreatitis
Pandol SJ, Lugea A, Mareninova OA, Smoot D, Gorelick FS, Gukovskaya AS, Gukovsky I. Investigating the Pathobiology of Alcoholic Pancreatitis. Alcohol Clinical And Experimental Research 2011, 35: 830-837. PMID: 21284675, PMCID: PMC3083481, DOI: 10.1111/j.1530-0277.2010.01408.x.Peer-Reviewed Original ResearchConceptsAlcoholic pancreatitisAlcohol-induced pancreatitisPotential therapeutic strategyDuration of drinkingKey cellular organellesEffects of alcoholCigarette smokingClinical benefitDietary factorsCommon causeEpidemiologic studiesPancreatitisTherapeutic strategiesAlcohol abuseAnimal modelsHeavy drinkersDisease initiationPathobiologic processesAlcohol effectsCellular organellesMolecular mechanismsEndoplasmic reticulumRecent findingsCurrent studySmoking
2010
Alcohol Abuse, Endoplasmic Reticulum Stress and Pancreatitis
Pandol SJ, Gorelick FS, Gerloff A, Lugea A. Alcohol Abuse, Endoplasmic Reticulum Stress and Pancreatitis. Digestive Diseases 2010, 28: 776-782. PMID: 21525762, PMCID: PMC3211518, DOI: 10.1159/000327212.Peer-Reviewed Original ResearchConceptsX-box binding protein 1Alcohol abuseChronic pancreatitisEthanol feedingUnfolded protein responseER stressSignificant pathological responseAcinar cellsAfrican American ethnicityEndoplasmic reticulum stressPancreatic manifestationAlcoholic pancreatitisAdaptive unfolded protein responseMinority of individualsChronic inflammationMost individualsPathological responseCommon causePancreatic diseaseApparent diseasePancreatitisBinding protein 1Heavy drinkersExocrine pancreasPancreas