How to Identify the Asymptomatic High-Risk Patient?
Schuijf J, Achenbach S, Zoghbi W, Boersma E, Raggi P, Weber M, Nagel E, Narula J, Wackers F, Poldermans D, Bax J. How to Identify the Asymptomatic High-Risk Patient? Current Problems In Cardiology 2009, 34: 539-577. PMID: 19804855, DOI: 10.1016/j.cpcardiol.2009.07.001.Peer-Reviewed Original ResearchConceptsElevated riskAsymptomatic high-risk patientsCardiovascular disease eventsHigh-risk patientsCause of mortalityUse of biomarkersNoninvasive imaging modalityIntermediate riskAsymptomatic individualsCardiovascular diseaseHigh riskDisease eventsPreventive measuresImaging modalitiesSubstantial proportionMorbidityPatientsRisk assessmentAdditional strategiesRiskMortalityTraditional risk assessmentLarge proportionGreat benefitIndividualsDetection of coronary artery disease with perfusion stress echocardiography using a novel ultrasound imaging agent: two Phase 3 international trials in comparison with radionuclide perfusion imaging
Senior R, Monaghan M, Main M, Zamorano J, Tiemann K, Agati L, Weissman N, Klein A, Marwick T, Ahmad M, DeMaria A, Zabalgoitia M, Becher H, Kaul S, Udelson J, Wackers F, Walovitch R, Picard M. Detection of coronary artery disease with perfusion stress echocardiography using a novel ultrasound imaging agent: two Phase 3 international trials in comparison with radionuclide perfusion imaging. European Heart Journal - Cardiovascular Imaging 2009, 10: 26-35. PMID: 19131498, DOI: 10.1093/ejechocard/jen321.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overArea Under CurveContrast MediaCoronary Artery DiseaseDipyridamoleEchocardiography, StressFemaleFluorocarbonsGated Blood-Pool ImagingHumansImage EnhancementImage Interpretation, Computer-AssistedInternational CooperationMaleMiddle AgedObserver VariationROC CurveSensitivity and SpecificityStatistics, NonparametricTomography, Emission-Computed, Single-PhotonYoung AdultConceptsChest pain patientsPain patientsStress echocardiographyPerfusion imagingNon-inferior sensitivityPhase 3 trialCoronary artery diseaseCoronary artery disease detectionQuantitative coronary angiographyNon-inferiority analysisRadionuclide perfusion imagingSingle photon emissionAdverse eventsArtery diseaseCoronary angiographyBlinded cardiologistsClinical reviewDipyridamole stressMyocardial perfusionSPECT perfusionInternational trialRAMP 1Diagnostic performanceSPECTCharacteristic curve