1992
Assessment of global and regional left ventricular performance at rest and during exercise after thrombolytic therapy for acute myocardial infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI) II study
Zaret B, Wackers F, Terrin M, Ross R, Weiss M, Slater J, Morrison J, Bourge R, Passamani E, Knatterud G, Braunwald E, Investigators. Assessment of global and regional left ventricular performance at rest and during exercise after thrombolytic therapy for acute myocardial infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI) II study. The American Journal Of Cardiology 1992, 69: 1-9. PMID: 1729855, DOI: 10.1016/0002-9149(92)90667-n.Peer-Reviewed Original ResearchConceptsLV ejection fractionLeft ventricular performanceEjection fractionRegional left ventricular performanceRegional ejection fractionHospital dischargeThrombolytic therapyVentricular performanceTreatment strategiesStrategies patientsComparable work loadNormal exercise responseRegional LV performanceMyocardial Infarction (TIMI) II trialAcute myocardial infarctionHospital-discharged patientsConservative strategyII studyII trialDischarge patientsConservative patientsClinical benefitLV performanceExercise studiesMyocardial infarction
1989
Quantitative radionuclide assessment of regional ventricular function after thrombolytic therapy for acute myocardial infarction: Results of phase I Thrombolysis in Myocardial Infarction (TIMI) trial
Wackers F, Terrin M, Kayden D, Knatterud G, Forman S, Braunwald E, Zaret B, Investigators. Quantitative radionuclide assessment of regional ventricular function after thrombolytic therapy for acute myocardial infarction: Results of phase I Thrombolysis in Myocardial Infarction (TIMI) trial. Journal Of The American College Of Cardiology 1989, 13: 998-1005. PMID: 2494246, DOI: 10.1016/0735-1097(89)90250-7.Peer-Reviewed Original ResearchConceptsRecombinant tissue-type plasminogen activatorLeft ventricular ejection fractionInfarct-related arteryVentricular ejection fractionGlobal left ventricular ejection fractionRegional left ventricular functionLeft ventricular functionEjection fractionAcute myocardial infarctionRegional ejection fractionVentricular functionMyocardial infarctionMean global left ventricular ejection fractionIntravenous recombinant tissue-type plasminogen activatorRegional left ventricular ejection fractionEffect of thrombolysisMyocardial Infarction trialRegional ventricular functionTissue-type plasminogen activatorPatients 185Sustained reperfusionIntravenous streptokinaseAngiographic reperfusionThrombolytic therapyPatency rates