2016
Defining outcomes of patients with clinical stage I small cell lung cancer upstaged at surgery
Thomas DC, Arnold BN, Rosen JE, Salazar MC, Blasberg JD, Detterbeck FC, Boffa DJ, Kim AW. Defining outcomes of patients with clinical stage I small cell lung cancer upstaged at surgery. Lung Cancer 2016, 103: 75-81. PMID: 28024700, DOI: 10.1016/j.lungcan.2016.11.016.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCarcinoma, Non-Small-Cell LungChemotherapy, AdjuvantCombined Modality TherapyDatabases, FactualFemaleGuidelines as TopicHumansLung NeoplasmsLymphatic MetastasisMaleMiddle AgedNeoplasm StagingOutcome Assessment, Health CarePneumonectomyPostoperative PeriodRadiotherapySmall Cell Lung CarcinomaSurvival AnalysisConceptsStage I small cell lung cancerClinical stage ISmall cell lung cancerCell lung cancerAdjuvant chemotherapySurgical resectionPathologic upstagingStage IRadiation therapyNodal diseaseLung cancerPositive lymph node involvementNational Cancer DatabaseOutcomes of patientsLymph node involvementProportion of patientsCurative intentNodal upstagingSCLC patientsUpstaged patientsAdjuvant therapyNode involvementIndependent predictorsInferior survivalT descriptorDetection of Occult Micrometastases in Patients With Clinical Stage I Non–Small-Cell Lung Cancer: A Prospective Analysis of Mature Results of CALGB 9761 (Alliance)
Martin LW, D'Cunha J, Wang X, Herzan D, Gu L, Abraham N, Demmy TL, Detterbeck FC, Groth SS, Harpole DH, Krasna MJ, Kernstine K, Kohman LJ, Patterson GA, Sugarbaker DJ, Vollmer RT, Maddaus MA, Kratzke RA. Detection of Occult Micrometastases in Patients With Clinical Stage I Non–Small-Cell Lung Cancer: A Prospective Analysis of Mature Results of CALGB 9761 (Alliance). Journal Of Clinical Oncology 2016, 34: 1484-1491. PMID: 26926677, PMCID: PMC4872306, DOI: 10.1200/jco.2015.63.4543.Peer-Reviewed Original ResearchConceptsN2 lymph nodesStage I NSCLCDisease-free survivalOccult micrometastasesLymph nodesCell lung cancerOverall survivalLung cancerStage IClinical stage I NSCLCPathologic stage I NSCLCComplete surgical stagingClinical stage IRT-PCRDecreased overall survivalNegative lymph nodesWorse survival rateSquamous cell carcinomaReal-time reverse transcriptase-polymerase chain reactionMulti-institutional trialReverse transcriptase-polymerase chain reactionTranscriptase-polymerase chain reactionWarrants further investigationSurgical stagingPrognostic significance
2014
The IASLC/ITMIG Thymic Epithelial Tumors Staging Project: Proposals for the N and M Components for the Forthcoming (8th) Edition of the TNM Classification of Malignant Tumors
Kondo K, Van Schil P, Detterbeck FC, Okumura M, Stratton K, Giroux D, Asamura H, Crowley J, Falkson C, Filosso PL, Giaccone G, Huang J, Kim J, Lucchi M, Marino M, Marom EM, Nicholson AG, Ruffini E, Committee††† O, Boards‡‡‡ M, Domain§§§ P. The IASLC/ITMIG Thymic Epithelial Tumors Staging Project: Proposals for the N and M Components for the Forthcoming (8th) Edition of the TNM Classification of Malignant Tumors. Journal Of Thoracic Oncology 2014, 9: s81-s87. PMID: 25396316, DOI: 10.1097/jto.0000000000000291.Peer-Reviewed Original ResearchMeSH KeywordsHumansLymphatic MetastasisNeoplasm MetastasisNeoplasm StagingNeoplasms, Glandular and EpithelialPrognosisSurvival AnalysisThymus NeoplasmsThe ITMIG/IASLC Thymic Epithelial Tumors Staging Project: A Proposed Lymph Node Map for Thymic Epithelial Tumors in the Forthcoming 8th Edition of the TNM Classification of Malignant Tumors
Bhora FY, Chen DJ, Detterbeck FC, Asamura H, Falkson C, Filosso PL, Giaccone G, Huang J, Kim J, Kondo K, Lucchi M, Marino M, Marom EM, Nicholson AG, Okumura M, Ruffini E, Van Schil P, Committee††† O, Boards‡‡‡ A. The ITMIG/IASLC Thymic Epithelial Tumors Staging Project: A Proposed Lymph Node Map for Thymic Epithelial Tumors in the Forthcoming 8th Edition of the TNM Classification of Malignant Tumors. Journal Of Thoracic Oncology 2014, 9: s88-s96. PMID: 25396317, DOI: 10.1097/jto.0000000000000293.Peer-Reviewed Original ResearchMeSH KeywordsHumansLymph NodesLymphatic MetastasisNeoplasms, Glandular and EpithelialThymus NeoplasmsConceptsThymic malignanciesNodal diseaseNeck surgeryNode mapInternational Thymic Malignancy Interest GroupLymph node dissectionThymic epithelial tumorsLymph node mapPrior classification systemsPrognostic Factors CommitteeNode dissectionNodal involvementNode stagingTNM classificationLung cancerMalignant tumorsEpithelial tumorsOtolaryngology-HeadLymphatic drainageIASLC stagingAmerican AcademyMalignancyStagingAnatomical studyDiseaseTreating Locally Advanced Disease: An Analysis of Very Large, Hilar Lymph Node Positive Non-Small Cell Lung Cancer Using the National Cancer Data Base
Moreno AC, Morgensztern D, Boffa DJ, Decker RH, Yu JB, Detterbeck FC, Wang Z, Rose MG, Kim AW. Treating Locally Advanced Disease: An Analysis of Very Large, Hilar Lymph Node Positive Non-Small Cell Lung Cancer Using the National Cancer Data Base. The Annals Of Thoracic Surgery 2014, 97: 1149-1155. PMID: 24582051, DOI: 10.1016/j.athoracsur.2013.12.045.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerNational Cancer Data BaseCell lung cancerOverall survivalPostoperative radiotherapyLung cancerRadiation therapyLymph Node-positive Non-small Cell Lung CancerNode-positive non-small cell lung cancerLarge non-small cell lung cancersAdvanced non-small cell lung cancerPositive non-small cell lung cancerFive-year overall survivalHilar lymph node involvementPrimary surgical therapyPrimary surgical treatmentLymph node involvementKaplan-Meier methodSurvival of patientsCox regression modelLog-rank testAdjuvant chemoradiationAdjuvant fashionAdvanced diseaseNeoadjuvant chemoradiation
2013
Lung Cancer: Is It Node Number or Location? Pardon Me, but What Is the Question?
Detterbeck FC. Lung Cancer: Is It Node Number or Location? Pardon Me, but What Is the Question? CHEST Journal 2013, 143: 1527-1529. PMID: 23732576, DOI: 10.1378/chest.13-0275.Peer-Reviewed Original ResearchSpecial Treatment Issues in Non-small Cell Lung Cancer Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
Kozower BD, Larner JM, Detterbeck FC, Jones DR. Special Treatment Issues in Non-small Cell Lung Cancer Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. CHEST Journal 2013, 143: e369s-e399s. PMID: 23649447, DOI: 10.1378/chest.12-2362.Peer-Reviewed Original ResearchConceptsSecond primary lung cancerChest wall involvementPrimary lung cancerLung cancerSurgical resectionPancoast tumorWall involvementAmerican CollegeChest Physicians Evidence-Based Clinical Practice GuidelinesMetachronous second primary lung cancerEvidence-based clinical practice guidelinesNon-small cell lung cancer diagnosisNon-small cell lung cancerLonger disease-free intervalCell lung cancer diagnosisIpsilateral different lobeMediastinal node involvementN2 nodal diseaseSpecial clinical casesThoracic Oncology NetworkAggressive surgical approachDisease-free intervalPrimary surgical resectionExperienced multidisciplinary teamLarge prospective studies
2010
Should the 7th Edition of the Lung Cancer Stage Classification System Change Treatment Algorithms in Non-small Cell Lung Cancer?
Boffa DJ, Detterbeck FC, Smith EJ, Rami-Porta R, Crowley J, Zelterman D, Tanoue L, Kim AW, Goldstraw P. Should the 7th Edition of the Lung Cancer Stage Classification System Change Treatment Algorithms in Non-small Cell Lung Cancer? Journal Of Thoracic Oncology 2010, 5: 1779-1783. PMID: 20975377, DOI: 10.1097/jto.0b013e3181ee80c7.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsCarcinoma, Non-Small-Cell LungHumansLung NeoplasmsLymphatic MetastasisNeoplasm StagingPrognosisConceptsNational Cancer DatabaseCancer DatabaseLung cancer databaseOverall prognosisPatient managementStage shiftNon-small cell lung cancer patientsNon-small cell lung cancerCell lung cancer patientsLung cancer staging systemDownstaging of tumorsLung cancer cliniciansCancer (AJCC) staging systemCell lung cancerLung cancer patientsEdition of TNMCancer SymposiumCancer cliniciansTreatment algorithmStaging systemCancer patientsLung cancerSpecific treatmentTreatment approachesTreatment changesCoping with the unexpected at surgery
Detterbeck FC, Terrien CM. Coping with the unexpected at surgery. Expert Review Of Respiratory Medicine 2010, 4: 115-122. PMID: 20387297, DOI: 10.1586/ers.09.59.Peer-Reviewed Original ResearchConceptsLung cancer surgeryMultidisciplinary tumor boardN2 node involvementPN2 diseaseNode involvementT4 tumorsExperienced centersSuch patientsCancer surgeryPreoperative assessmentTumor boardChest wallBetter outcomesIntraoperative surprisesSurgeryResectionMediastinalPatientsTumorsCareful planningDiseaseClassification of the Thoroughness of Mediastinal Staging of Lung Cancer
Detterbeck F, Puchalski J, Rubinowitz A, Cheng D. Classification of the Thoroughness of Mediastinal Staging of Lung Cancer. CHEST Journal 2010, 137: 436-442. PMID: 20133290, DOI: 10.1378/chest.09-1378.Books
2009
New TNM classification for non-small-cell lung cancer
Tanoue LT, Detterbeck FC. New TNM classification for non-small-cell lung cancer. Expert Review Of Anticancer Therapy 2009, 9: 413-423. PMID: 19374596, DOI: 10.1586/era.09.11.Peer-Reviewed Original Research
2008
Management Algorithms for Stage IIIA Non–Small Cell Lung Cancer with N2 Node Involvement
Detterbeck F, Sukumar MS. Management Algorithms for Stage IIIA Non–Small Cell Lung Cancer with N2 Node Involvement. Thoracic Surgery Clinics 2008, 18: 437-441. PMID: 19086612, DOI: 10.1016/j.thorsurg.2008.08.006.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsCarcinoma, Non-Small-Cell LungCombined Modality TherapyHumansLung NeoplasmsLymphatic MetastasisMediastinumNeoplasm StagingInvited Commentary
Detterbeck F. Invited Commentary. The Annals Of Thoracic Surgery 2008, 86: 1631. PMID: 19049762, DOI: 10.1016/j.athoracsur.2008.08.055.Peer-Reviewed Original ResearchWhat to do with “Surprise” N2?: Intraoperative Management of Patients with Non-small Cell Lung Cancer
Detterbeck F. What to do with “Surprise” N2?: Intraoperative Management of Patients with Non-small Cell Lung Cancer. Journal Of Thoracic Oncology 2008, 3: 289-302. PMID: 18317073, DOI: 10.1097/jto.0b013e3181630ebd.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Non-Small-Cell LungHumansIntraoperative CareLung NeoplasmsLymph Node ExcisionLymphatic MetastasisMediastinumNeoplasm StagingPrognosisConceptsNon-small cell lung cancerMediastinal lymph node dissectionLymph node dissectionMediastinal lymph nodesPositive prognostic factorCell lung cancerAdjuvant therapyNode dissectionLung resectionLymph nodesMalignant involvementPrognostic factorsIntraoperative managementLung cancerPatientsConflicting dataResectionTherapyCancerDiseaseDissectionComprehensive review
2007
Invasive Mediastinal Staging of Lung Cancer ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition)
Detterbeck FC, Jantz MA, Wallace M, Vansteenkiste J, Silvestri GA. Invasive Mediastinal Staging of Lung Cancer ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition). CHEST Journal 2007, 132: 202s-220s. PMID: 17873169, DOI: 10.1378/chest.07-1362.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerLymph nodesInvasive stagingMediastinal nodesClinical stage I non-small cell lung cancerLung Cancer ACCP Evidence-Based Clinical Practice GuidelinesACCP Evidence-Based Clinical Practice GuidelinesStage I non-small cell lung cancerNeedle techniqueEvidence-based clinical practice guidelinesLeft upper lobe tumorsNormal-sized lymph nodesPositron emission tomography scanningPET scan findingsUpper lobe tumorsMediastinal lymph nodesCell lung cancerClinical practice guidelinesStaging of patientsInvasive mediastinal stagingHigher FN rateInvasive confirmationMediastinal infiltrationNode enlargementScan findingsNoninvasive Staging of Non-small Cell Lung Cancer ACCP Evidenced-Based Clinical Practice Guidelines (2nd Edition)
Silvestri GA, Gould MK, Margolis ML, Tanoue LT, McCrory D, Toloza E, Detterbeck F. Noninvasive Staging of Non-small Cell Lung Cancer ACCP Evidenced-Based Clinical Practice Guidelines (2nd Edition). CHEST Journal 2007, 132: 178s-201s. PMID: 17873168, DOI: 10.1378/chest.07-1360.Peer-Reviewed Original ResearchConceptsChest CT scanningPET scanningCT scanningMediastinal metastasesMetastatic diseaseStaging studiesLung cancerPractice guidelinesLung Cancer ACCP Evidence-Based Clinical Practice GuidelinesACCP Evidence-Based Clinical Practice GuidelinesEvidence-based clinical practice guidelinesMediastinal lymph node metastasisPositron emission tomography scanningTest characteristicsLung cancer guidelinesDistant metastatic diseaseLymph node metastasisClinical practice guidelinesMalignant lymph nodesNoninvasive imaging studiesAbnormal findingsCancer guidelinesLymph nodesNode metastasisAccurate stagingEvolution and science, progress and change
Detterbeck FC. Evolution and science, progress and change. Thorax 2007, 62: 654. PMID: 17687093, PMCID: PMC2117279, DOI: 10.1136/thx.2007.077594.Peer-Reviewed Original Research
2006
Postoperative Radiotherapy for Stage II or III Non–Small-Cell Lung Cancer Using the Surveillance, Epidemiology, and End Results Database
Lally BE, Zelterman D, Colasanto JM, Haffty BG, Detterbeck FC, Wilson LD. Postoperative Radiotherapy for Stage II or III Non–Small-Cell Lung Cancer Using the Surveillance, Epidemiology, and End Results Database. Journal Of Clinical Oncology 2006, 24: 2998-3006. PMID: 16769986, DOI: 10.1200/jco.2005.04.6110.Peer-Reviewed Original ResearchConceptsT3-4 tumour stageUse of PORTN2 nodal diseaseEnd Results (SEER) databasePostoperative radiotherapyCell lung cancerLymph nodesNodal diseaseResults databaseTumor stageLung cancerNode stageStage IIHigher American Joint CommitteeAdvanced node stageAmerican Joint CommitteePopulation-based cohortLarger tumor sizeMedian followPerioperative mortalityMale sexTumor sizeSubset analysisCancer stageInclusion criteriaInvited commentary
Detterbeck FC. Invited commentary. The Annals Of Thoracic Surgery 2006, 81: 330. PMID: 16368393, DOI: 10.1016/j.athoracsur.2005.08.024.Peer-Reviewed Original Research
2003
Invasive Staging* The Guidelines
Detterbeck FC, DeCamp MM, Kohman LJ, Silvestri GA. Invasive Staging* The Guidelines. CHEST Journal 2003, 123: 167s-175s. PMID: 12527576, DOI: 10.1378/chest.123.1_suppl.167s.Peer-Reviewed Original ResearchConceptsInvasive staging proceduresTransbronchial needle aspirationTransthoracic needle aspirationStaging procedureNeedle aspirationInvasive staging testsMediastinal lymph nodesFine-needle aspirationInvasive stagingLow morbidityLymph nodesMalignant involvementMediastinal nodesRadiographic stagingLung cancerStaging testsEndoscopic ultrasoundMultidisciplinary discussionPhysiologic considerationsFalse negative rateMediastinoscopyParticular riskLow false negative rateReasonable alternative