2024
International reproducibility study of thymic epithelial tumors staging: pT stage is an issue. proposals for improvement. A RYTHMIC/ITMIG study
Molina T, Roden A, Szolkowska M, Shimizu S, Moreira A, Chalabreysse L, Besse B, de Montpréville V, Marom E, Detterbeck F, Girard N, Nicholson A, Marx A. International reproducibility study of thymic epithelial tumors staging: pT stage is an issue. proposals for improvement. A RYTHMIC/ITMIG study. Lung Cancer 2024, 189: 107479. PMID: 38306885, DOI: 10.1016/j.lungcan.2024.107479.Peer-Reviewed Original ResearchThymic epithelial tumorsInternational Thymic Malignancy Interest GroupPT stageTNM classificationMediastinal pleuraInternational panel of pathologistsPathological tumor stagePanel of pathologistsCohort of casesEpithelial tumorsTumor stageTNM systemInterobserver reproducibilityAncillary testsExpert pathologistsPleuraValidation seriesTNMPathologistsLungPericardiumInternational panelPotential interventionsInternational levelTumor
2018
Eighth Edition Staging of Thoracic Malignancies: Implications for the Reporting Pathologist
Nicholson AG, Tsao MS, Travis WD, Patil DT, Galateau-Salle F, Marino M, Dacic S, Beasley MB, Butnor KJ, Yatabe Y, Pass HI, Rusch VW, Detterbeck FC, Asamura H, Rice TW, Rami-Porta R. Eighth Edition Staging of Thoracic Malignancies: Implications for the Reporting Pathologist. Archives Of Pathology & Laboratory Medicine 2018, 142: 645-661. PMID: 29480761, DOI: 10.5858/arpa.2017-0245-ra.Peer-Reviewed Original ResearchConceptsAmerican Joint CommitteeInternational Cancer ControlThoracic malignanciesReporting pathologistCancer controlJoint CommitteeWorldwide Esophageal Cancer CollaborationInternational Thymic Malignancy Interest GroupUS National Cancer DatabaseInternational Mesothelioma Interest GroupEighth edition stagingNational Cancer DatabaseThymic epithelial tumorsPrognostic Factors CommitteeEdition stagingStaging ManualEsophagogastric junctionThoracic cancerLung cancerCancer DatabaseRespective tumorsEpithelial tumorsEpithelial cancersCancerStaging
2017
Positron Emission Tomography in Thymic Tumors: Analysis Using a Prospective Research Database
Korst RJ, Fernando S, Catlin AC, Rutledge JR, Girard N, Huang J, Detterbeck F, Database C. Positron Emission Tomography in Thymic Tumors: Analysis Using a Prospective Research Database. The Annals Of Thoracic Surgery 2017, 104: 1815-1820. PMID: 29033016, PMCID: PMC5785101, DOI: 10.1016/j.athoracsur.2017.06.053.Peer-Reviewed Original ResearchConceptsPositron emission tomographyInternational Thymic Malignancy Interest GroupHistologic typeThymic malignanciesPretreatment workupPathologic stageEmission tomographyProspective databaseThymic tumorsTumor stageMaximum standardized uptake valueProspective research databaseHistologic tumor typeThymic epithelial tumorsStandardized uptake valueCharacteristic curveAnalysis of receiverClinicopathologic featuresRare tumorEpithelial tumorsLarge cohortResearch DatabaseUptake valueTumor typesPatients
2016
Thymic Carcinoma Management Patterns among International Thymic Malignancy Interest Group (ITMIG) Physicians with Consensus from the Thymic Carcinoma Working Group
Shepherd A, Riely G, Detterbeck F, Simone CB, Ahmad U, Huang J, Korst R, Rajan A, Rimner A. Thymic Carcinoma Management Patterns among International Thymic Malignancy Interest Group (ITMIG) Physicians with Consensus from the Thymic Carcinoma Working Group. Journal Of Thoracic Oncology 2016, 12: 745-751. PMID: 27876674, PMCID: PMC5545114, DOI: 10.1016/j.jtho.2016.11.2219.Peer-Reviewed Original ResearchConceptsInternational Thymic Malignancy Interest GroupThymic carcinomaAreas of controversyResectable diseaseMultimodality therapyClinical practiceFirst-line chemotherapy regimenDefinitive surgical resectionRare epithelial malignancyManagement of patientsCurrent clinical practiceFit patientsAdjuvant therapyChemotherapy regimenSurgical resectionThymic malignanciesHistologic confirmationTreatment courseTreatment strategiesEpithelial malignanciesGreat vesselsMultidisciplinary discussionGroup physiciansWorking GroupCarcinomaThe impact of ChART on the science of thymic malignancies
Detterbeck F. The impact of ChART on the science of thymic malignancies. Journal Of Thoracic Disease 2016, 8: 1921. PMID: 27619638, PMCID: PMC4999693, DOI: 10.21037/jtd.2016.07.64.Peer-Reviewed Original ResearchInternational Thymic Malignancy Interest GroupThymic malignanciesRare diseaseSuch rare diseasesOrphan diseaseChinese AllianceDiseasePostoperative Radiation Therapy Is Associated with Longer Overall Survival in Completely Resected Stage II and III Thymoma—An Analysis of the International Thymic Malignancies Interest Group Retrospective Database
Rimner A, Yao X, Huang J, Antonicelli A, Ahmad U, Korst RJ, Detterbeck F, Gomez DR. Postoperative Radiation Therapy Is Associated with Longer Overall Survival in Completely Resected Stage II and III Thymoma—An Analysis of the International Thymic Malignancies Interest Group Retrospective Database. Journal Of Thoracic Oncology 2016, 11: 1785-1792. PMID: 27346413, PMCID: PMC5257334, DOI: 10.1016/j.jtho.2016.06.011.Peer-Reviewed Original ResearchConceptsPostoperative radiation therapyStage IIOS benefitRadiation therapyUse of PORTMasaoka-Koga stage IIInternational Thymic Malignancy Interest GroupStage II thymomaOverall survival benefitPrimary end pointMultivariate Cox modelLonger overall survivalLog-rank testIndividual patient dataImproved OSParaneoplastic syndromeOverall survivalSurvival benefitOS ratesHistologic subtypePatient populationRetrospective databaseUnivariate analysisCox modelThymomaComparison of outcomes between neuroendocrine thymic tumours and other subtypes of thymic carcinomas: a joint analysis of the European Society of Thoracic Surgeons and the International Thymic Malignancy Interest Group†
Filosso PL, Yao X, Ruffini E, Ahmad U, Antonicelli A, Huang J, Guerrera F, Venuta F, van Raemdonck D, Travis W, Lucchi M, Rimner A, Thomas P, Weder W, Rocco G, Detterbeck F, Korst R. Comparison of outcomes between neuroendocrine thymic tumours and other subtypes of thymic carcinomas: a joint analysis of the European Society of Thoracic Surgeons and the International Thymic Malignancy Interest Group†. European Journal Of Cardio-Thoracic Surgery 2016, 50: 766-771. PMID: 27032473, PMCID: PMC6279171, DOI: 10.1093/ejcts/ezw107.Peer-Reviewed Original ResearchConceptsNeuroendocrine thymic tumoursRecurrence-free survivalThymic carcinomaOverall survivalSurvival rateThymic tumorsThoracic surgeonsFive-year recurrence-free survivalWorld Health Organization histological classificationRetrospective multicentre cohort studyInternational Thymic Malignancy Interest GroupMedian overall survivalMulticentre cohort studyEuropean SocietyKaplan-Meier methodThymic epithelial tumorsLarge clinical seriesLog-rank testComparison of outcomesGroup of tumorsR0 resectionCohort studyPrognostic factorsNET patientsTC patients
2014
Development of the International Thymic Malignancy Interest Group International Database: An Unprecedented Resource for the Study of a Rare Group of Tumors
Huang J, Ahmad U, Antonicelli A, Catlin AC, Fang W, Gomez D, Loehrer P, Lucchi M, Marom E, Nicholson A, Ruffini E, Travis W, Van Schil P, Wakelee H, Yao X, Detterbeck F, Committee and Contributors O. Development of the International Thymic Malignancy Interest Group International Database: An Unprecedented Resource for the Study of a Rare Group of Tumors. Journal Of Thoracic Oncology 2014, 9: 1573-1578. PMID: 25521402, DOI: 10.1097/jto.0000000000000269.Peer-Reviewed Original ResearchConceptsInternational Thymic Malignancy Interest GroupThymic carcinomaThymic carcinoidMedian overall survivalSingle-institution seriesOverall survivalThymic malignanciesMyasthenia gravisRare tumorHistologic classificationSex distributionThymomaCarcinoidsCarcinomaRetrospective dataType B2Rare groupTumorsPatientsMalignancyGreater proportionInternational databasesYearsGravisGroupOutcome of primary neuroendocrine tumors of the thymus: A joint analysis of the International Thymic Malignancy Interest Group and the European Society of Thoracic Surgeons databases
Filosso PL, Yao X, Ahmad U, Zhan Y, Huang J, Ruffini E, Travis W, Lucchi M, Rimner A, Antonicelli A, Guerrera F, Detterbeck F, Committee E. Outcome of primary neuroendocrine tumors of the thymus: A joint analysis of the International Thymic Malignancy Interest Group and the European Society of Thoracic Surgeons databases. Journal Of Thoracic And Cardiovascular Surgery 2014, 149: 103-109.e2. PMID: 25308116, DOI: 10.1016/j.jtcvs.2014.08.061.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overChemotherapy, AdjuvantDatabases, FactualFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisNeoadjuvant TherapyNeoplasm GradingNeoplasm Recurrence, LocalNeoplasm StagingNeuroendocrine TumorsProportional Hazards ModelsRadiotherapy, AdjuvantRetrospective StudiesRisk FactorsThymectomyThymus NeoplasmsTime FactorsTreatment OutcomeYoung AdultConceptsInternational Thymic Malignancy Interest GroupMasaoka-Koga stageOverall survivalCompleteness of resectionPrimary neuroendocrine tumorThoracic Surgeons databasePrognostic factorsHistologic subtypeSurgeons databaseNeuroendocrine tumorsHigher biologic aggressivenessMasaoka-Koga stage ICommon histologic subtypeMedian overall survivalEuropean SocietyRetrospective multicenter studyKaplan-Meier methodStrong prognostic factorLog-rank testInduction therapyAdjuvant treatmentCumulative incidenceResection statusComplete resectionMulticenter studyThe ITMIG/IASLC Thymic Epithelial Tumors Staging Project: A Proposed Lymph Node Map for Thymic Epithelial Tumors in the Forthcoming 8th Edition of the TNM Classification of Malignant Tumors
Bhora FY, Chen DJ, Detterbeck FC, Asamura H, Falkson C, Filosso PL, Giaccone G, Huang J, Kim J, Kondo K, Lucchi M, Marino M, Marom EM, Nicholson AG, Okumura M, Ruffini E, Van Schil P, Committee††† O, Boards‡‡‡ A. The ITMIG/IASLC Thymic Epithelial Tumors Staging Project: A Proposed Lymph Node Map for Thymic Epithelial Tumors in the Forthcoming 8th Edition of the TNM Classification of Malignant Tumors. Journal Of Thoracic Oncology 2014, 9: s88-s96. PMID: 25396317, DOI: 10.1097/jto.0000000000000293.Peer-Reviewed Original ResearchConceptsThymic malignanciesNodal diseaseNeck surgeryNode mapInternational Thymic Malignancy Interest GroupLymph node dissectionThymic epithelial tumorsLymph node mapPrior classification systemsPrognostic Factors CommitteeNode dissectionNodal involvementNode stagingTNM classificationLung cancerMalignant tumorsEpithelial tumorsOtolaryngology-HeadLymphatic drainageIASLC stagingAmerican AcademyMalignancyStagingAnatomical studyDiseaseA Modern Definition of Mediastinal Compartments
Carter BW, Tomiyama N, Bhora FY, de Christenson M, Nakajima J, Boiselle PM, Detterbeck FC, Marom EM. A Modern Definition of Mediastinal Compartments. Journal Of Thoracic Oncology 2014, 9: s97-s101. PMID: 25396318, DOI: 10.1097/jto.0000000000000292.Peer-Reviewed Original ResearchConceptsInternational Thymic Malignancy Interest GroupProspective clinical trialsLateral chest radiographsParavertebral compartmentMediastinal massClinical trialsDifferential diagnosisChest radiographsSurgical proceduresClinical classificationMediastinal compartmentClinical casesAnatomic boundariesArbitrary landmarksCompartmentsMediastinumBiopsyA Practical Guide from the International Thymic Malignancy Interest Group (ITMIG) Regarding the Radiographic Assessment of Treatment Response of Thymic Epithelial Tumors Using Modified RECIST Criteria
Benveniste MF, Korst RJ, Rajan A, Detterbeck FC, Marom EM. A Practical Guide from the International Thymic Malignancy Interest Group (ITMIG) Regarding the Radiographic Assessment of Treatment Response of Thymic Epithelial Tumors Using Modified RECIST Criteria. Journal Of Thoracic Oncology 2014, 9: s119-s124. PMID: 25396308, DOI: 10.1097/jto.0000000000000296.Peer-Reviewed Original ResearchConceptsInternational Thymic Malignancy Interest GroupTumor measurementsProgression-free survivalThymic epithelial tumorsStandard outcome measuresMulti-institutional studyAccurate tumor measurementsRECIST criteriaTumor responseClinical trialsRadiographic assessmentTreatment responseEpithelial tumorsOutcome measuresResponse rateInterobserver variabilityThymomaPractical guideInterest group recommendationsChemotherapyPleuraTumorsITMIG Consensus Statement on the Use of the WHO Histological Classification of Thymoma and Thymic Carcinoma: Refined Definitions, Histological Criteria, and Reporting
Marx A, Ströbel P, Badve SS, Chalabreysse L, Chan JK, Chen G, de Leval L, Detterbeck F, Girard N, Huang J, Kurrer MO, Lauriola L, Marino M, Matsuno Y, Molina TJ, Mukai K, Nicholson AG, Nonaka D, Rieker R, Rosai J, Ruffini E, Travis WD. ITMIG Consensus Statement on the Use of the WHO Histological Classification of Thymoma and Thymic Carcinoma: Refined Definitions, Histological Criteria, and Reporting. Journal Of Thoracic Oncology 2014, 9: 596-611. PMID: 24722150, DOI: 10.1097/jto.0000000000000154.Peer-Reviewed Original ResearchConceptsThymic carcinomaThymic epithelial tumorsB3 thymomaEpithelial tumorsInternational Thymic Malignancy Interest GroupWorld Health Organization classificationPoor interobserver reproducibilityHistological patternOrganization classificationConsensus statementHistological classificationHistological criteriaThymoma subtypesThymomaAtypical typeGrading systemInterobserver reproducibilityTumorsCarcinomaReproducibility studyRefined criteriaMorphological overlapSubtypesVariable proportionsThe International Thymic Malignancy Interest Group Thymic Initiative: A State-of-the-Art Study of Thymic Malignancies
Detterbeck F, Korst R. The International Thymic Malignancy Interest Group Thymic Initiative: A State-of-the-Art Study of Thymic Malignancies. Seminars In Thoracic And Cardiovascular Surgery 2014, 26: 317-322. PMID: 25837546, DOI: 10.1053/j.semtcvs.2015.02.002.Peer-Reviewed Original ResearchConceptsInternational Thymic Malignancy Interest GroupThymic malignanciesReporting of outcomesRare tumorLung cancer
2013
Historical perspectives: The evolution of the thymic epithelial tumors staging system
Filosso PL, Ruffini E, Lausi PO, Lucchi M, Oliaro A, Detterbeck F. Historical perspectives: The evolution of the thymic epithelial tumors staging system. Lung Cancer 2013, 83: 126-132. PMID: 24377980, DOI: 10.1016/j.lungcan.2013.09.013.Peer-Reviewed Original ResearchConceptsUnion Internationale Contre le CancerInternational Thymic Malignancy Interest GroupThymic epithelial tumorsStaging systemEpithelial tumorsThymoma: current diagnosis and treatment.
Detterbeck FC, Zeeshan A. Thymoma: current diagnosis and treatment. Chinese Medical Journal 2013, 126: 2186-91. PMID: 23769581, DOI: 10.3760/cma.j.issn.0366-6999.20130177.Peer-Reviewed Original ResearchConceptsComplete resectionInternational Thymic Malignancy Interest GroupMasaoka-Koga classificationMainstay of treatmentMajor prognostic factorAnterior mediastinal tumorTreatment of thymomaEarly-stage thymomaRare malignant tumorCore needle biopsyStandard diagnostic modalityFine-needle aspirationFormal systematic reviewMajor blood vesselsIVA tumorsPreoperative chemotherapyPrimary surgeryPostoperative radiationPrognostic factorsSurgical resectionThymic malignanciesMediastinal tumorMyasthenia gravisThymoma resectionIntravenous contrastThe international thymic malignancy interest group.
Detterbeck FC. The international thymic malignancy interest group. Journal Of The National Comprehensive Cancer Network 2013, 11: 589-93. PMID: 23667208, DOI: 10.6004/jnccn.2013.0074.Peer-Reviewed Original ResearchConceptsInternational Thymic Malignancy Interest GroupNCCN Clinical Practice GuidelinesMore evidence-based guidelinesSeries of patientsClinical practice guidelinesEvidence-based guidelinesSignificant clinical valueThymic tumorsTreatment recommendationsPractice guidelinesClinical valueOrphan diseaseGuidelinesPatientsGroupTumorsDiseaseOncology
2011
Standard Outcome Measures for Thymic Malignancies
Huang J, Detterbeck FC, Wang Z, Loehrer PJ. Standard Outcome Measures for Thymic Malignancies. Journal Of Thoracic Oncology 2011, 6: s1691-s1697. PMID: 21847049, DOI: 10.1097/jto.0b013e3182254ac1.Peer-Reviewed Original ResearchThymic malignanciesOutcome measuresInternational Thymic Malignancy Interest GroupPatterns of recurrenceCause of deathStandard outcome measuresDisease progressionClinical studiesMalignancyAvailable experiencePatientsRecurrence
2010
Standard Outcome Measures for Thymic Malignancies
Huang J, Detterbeck FC, Wang Z, Loehrer PJ. Standard Outcome Measures for Thymic Malignancies. Journal Of Thoracic Oncology 2010, 5: 2017-2023. PMID: 20978450, DOI: 10.1097/jto.0b013e3181f13682.Peer-Reviewed Original ResearchConceptsThymic malignanciesOutcome measuresInternational Thymic Malignancy Interest GroupPatterns of recurrenceCause of deathStandard outcome measuresDisease progressionClinical studiesMalignancyAvailable experiencePatientsRecurrence