2019
A Recurrence Predictive Model for Thymic Tumors and Its Implication for Postoperative Management: a Chinese Alliance for Research in Thymomas Database Study
Liu H, Gu Z, Qiu B, Detterbeck FC, Roden AC, Ruffini E, Okumura M, Girard N, Xiang Y, Liu Y, Du Z, Hao Y, Fu J, Zhang P, Pang L, Chen K, Wang Y, Yu Z, Mao T, Fang W, Group A. A Recurrence Predictive Model for Thymic Tumors and Its Implication for Postoperative Management: a Chinese Alliance for Research in Thymomas Database Study. Journal Of Thoracic Oncology 2019, 15: 448-456. PMID: 31726106, DOI: 10.1016/j.jtho.2019.10.018.Peer-Reviewed Original ResearchConceptsHigh-risk patientsAdjuvant therapyPostoperative yearThymic carcinomaComplete resectionPostoperative managementNeuroendocrine tumorsBootstrap-corrected C-indexChinese AlliancePostoperative adjuvant therapyIndependent predictive factorsLow-risk patientsMultivariate Cox regressionOverall survival rateAppropriate postoperative managementThymic epithelial tumorsHigh-risk groupLow-risk groupIIIA tumorsLocoregional recurrenceDisease recurrenceB3 thymomaHistologic typeNomogram modelT stage
2017
Paraneoplastic Syndromes and Thymic Malignancies: An Examination of the International Thymic Malignancy Interest Group Retrospective Database
Padda SK, Yao X, Antonicelli A, Riess JW, Shang Y, Shrager JB, Korst R, Detterbeck F, Huang J, Burt BM, Wakelee HA, Badve SS. Paraneoplastic Syndromes and Thymic Malignancies: An Examination of the International Thymic Malignancy Interest Group Retrospective Database. Journal Of Thoracic Oncology 2017, 13: 436-446. PMID: 29191778, PMCID: PMC5983900, DOI: 10.1016/j.jtho.2017.11.118.Peer-Reviewed Original ResearchConceptsThymic epithelial tumorsIndependent prognostic factorOverall survivalPrognostic factorsPrognostic roleRetrospective databaseCox proportional hazards modelKaplan-Meier methodRecurrence-free survivalProportional hazards modelParaneoplastic syndromeCumulative incidenceResection statusTotal thymectomyMyasthenia gravisThymic malignanciesHistologic typeSyndrome statusFemale sexTreatment characteristicsEpithelial tumorsHazards modelLower CIRSyndromeMultivariate analysisInterobserver Variation among Pathologists and Refinement of Criteria in Distinguishing Separate Primary Tumors from Intrapulmonary Metastases in Lung
Nicholson AG, Torkko K, Viola P, Duhig E, Geisinger K, Borczuk AC, Hiroshima K, Tsao MS, Warth A, Lantuejoul S, Russell PA, Thunnissen E, Marchevsky A, Mino-Kenudson M, Beasley MB, Botling J, Dacic S, Yatabe Y, Noguchi M, Travis WD, Kerr K, Hirsch FR, Chirieac LR, Wistuba II, Moreira A, Chung JH, Chou TY, Bubendorf L, Chen G, Pelosi G, Poleri C, Detterbeck FC, Franklin WA. Interobserver Variation among Pathologists and Refinement of Criteria in Distinguishing Separate Primary Tumors from Intrapulmonary Metastases in Lung. Journal Of Thoracic Oncology 2017, 13: 205-217. PMID: 29127023, PMCID: PMC6276791, DOI: 10.1016/j.jtho.2017.10.019.Peer-Reviewed Original ResearchConceptsSecond primary lung cancerIntrapulmonary metastasesComprehensive histologic assessmentHistologic featuresHistologic patternLung pathologistsHistologic assessmentNuclear pleomorphismMitotic rateSeparate primary tumorsPrimary lung cancerMain histologic typesPredominant patternDistinctive histologic featuresMultiple tumor nodulesClear cell changeRefinement of criteriaLepidic growthHistologic subtypeHistologic typeVascular invasionPrimary tumorLung cancerTumor extentLung tumorsPositron Emission Tomography in Thymic Tumors: Analysis Using a Prospective Research Database
Korst RJ, Fernando S, Catlin AC, Rutledge JR, Girard N, Huang J, Detterbeck F, Database C. Positron Emission Tomography in Thymic Tumors: Analysis Using a Prospective Research Database. The Annals Of Thoracic Surgery 2017, 104: 1815-1820. PMID: 29033016, PMCID: PMC5785101, DOI: 10.1016/j.athoracsur.2017.06.053.Peer-Reviewed Original ResearchConceptsPositron emission tomographyInternational Thymic Malignancy Interest GroupHistologic typeThymic malignanciesPretreatment workupPathologic stageEmission tomographyProspective databaseThymic tumorsTumor stageMaximum standardized uptake valueProspective research databaseHistologic tumor typeThymic epithelial tumorsStandardized uptake valueCharacteristic curveAnalysis of receiverClinicopathologic featuresRare tumorEpithelial tumorsLarge cohortResearch DatabaseUptake valueTumor typesPatients
2016
The IASLC Lung Cancer Staging Project: Methodology and Validation Used in the Development of Proposals for Revision of the Stage Classification of NSCLC in the Forthcoming (Eighth) Edition of the TNM Classification of Lung Cancer
Detterbeck FC, Chansky K, Groome P, Bolejack V, Crowley J, Shemanski L, Kennedy C, Krasnik M, Peake M, Rami-Porta R, Goldstraw P, Rami-Porta R, Asamura H, Ball D, Beer D, Beyruti R, Bolejack V, Chansky K, Crowley J, Detterbeck F, Eberhardt W, Edwards J, Galateau-Sallé F, Giroux D, Gleeson F, Groome P, Huang J, Kennedy C, Kim J, Kim Y, Kingsbury L, Kondo H, Krasnik M, Kubota K, Lerut A, Lyons G, Marino M, Marom E, van Meerbeeck J, Mitchell A, Nakano T, Nicholson A, Nowak A, Peake M, Rice T, Rosenzweig K, Ruffini E, Rusch V, Saijo N, Van Schil P, Sculier J, Shemanski L, Stratton K, Suzuki K, Tachimori Y, Thomas C, Travis W, Tsao M, Turrisi A, Vansteenkiste J, Watanabe H, Wu Y, Baas P, Erasmus J, Hasegawa S, Inai K, Kernstine K, Kindler H, Krug L, Nackaerts K, Pass H, Rice D, Falkson C, Filosso P, Giaccone G, Kondo K, Lucchi M, Okumura M, Blackstone E, Cavaco F, Barrera E, Arca J, Lamelas I, Obrer A, Jorge R, Ball D, Bascom G, Orozco A, Castro M, Blum M, Chimondeguy D, Cvijanovic V, Defranchi S, de Olaiz Navarro B, Campuzano I, Vidueira I, Araujo E, García F, Fong K, Corral G, González S, Gilart J, Arangüena L, Barajas S, Girard P, Goksel T, Budiño M, Casaurrán G, Blanco J, Hernández J, Rodríguez H, Collantes J, Heras M, Elena J, Jakobsen E, Kostas S, Atance P, Ares A, Liao M, Losanovscky M, Lyons G, Magaroles R, De Esteban Júlvez L, Gorospe M, McCaughan B, Kennedy C, Íñiguez R, Sorribes L, Gozalo S, de Arriba C, Delgado M, Alarcón J, Cuesta J, Park J, Pass H, Fernández M, Rosenberg M, Ruffini E, Rusch V, de Cos Escuín J, Vinuesa A, Mitjans M, Strand T, Subotic D, Swisher S, Terra R, Thomas C, Tournoy K, Van Schil P, Velasquez M, Wu Y, Yokoi K, Rami-Porta R, Ball D, Bolejack V, Crowley J, Giroux D, Kim J, Lyons G, Rice T, Suzuki K, Thomas C, Travis W, Wu Y, Asamura H, Ball D, Chansky K, Crowley J, Goldstraw P, Rusch V, van Schil P, Vansteenkiste J, Watanabe H, Wu Y, Zielinski M, Eberhardt W, Chansky K, Crowley J, Kim Y, Kondo H, Mitchell A, Turrisi A, Groome P, Detterbeck F, Bolejack V, Crowley J, Kennedy C, Krasnik M, Peake M, Sculier J, Chansky K, Crowley J, Giroux D, Gleeson F, van Meeerbeeck J, Travis W, Asamura H, Chansky K, Crowley J, Giroux D, Nicholson A, Beyruti R, Chansky K, Crowley J, Kubota K, Turrisi A, Tsao M, Beer D, Crowley J, Wu Y, Travis W, Asamura H, Bankier A, Beasley M, Detterbeck F, Flieder D, Goo J, MacMahon H, Naidich D, Nicholson A, Powell C, Prokop M, Rami-Porta R, Rusch V, van Schil P, Yatabe Y, Detterbeck F, Arenberg D, Asamura H, Bolejack V, Crowley J, Donington J, Franklin W, Girard N, Marom E, Mazzone P, Nicholson A, Rusch V, Tanoue L, Travis W. The IASLC Lung Cancer Staging Project: Methodology and Validation Used in the Development of Proposals for Revision of the Stage Classification of NSCLC in the Forthcoming (Eighth) Edition of the TNM Classification of Lung Cancer. Journal Of Thoracic Oncology 2016, 11: 1433-1446. PMID: 27448762, DOI: 10.1016/j.jtho.2016.06.028.Peer-Reviewed Original ResearchConceptsLung cancerLung cancer stage classificationIASLC Lung Cancer Staging ProjectLung Cancer Staging ProjectDifferent patient cohortsCancer stage classificationPrognostic Factors CommitteeAnatomic extentHistologic typeTNM classificationDefinition of tumorMetastasis classificationPatient cohortMetastasis categoryStage groupingEnough patientsStage classificationEighth editionCancerPatientsDiscriminatory abilityExternal validationTumorsInternational databasesEvidence of applicabilityThe IASLC Lung Cancer Staging Project: Summary of Proposals for Revisions of the Classification of Lung Cancers with Multiple Pulmonary Sites of Involvement in the Forthcoming Eighth Edition of the TNM Classification
Detterbeck FC, Nicholson AG, Franklin WA, Marom EM, Travis WD, Girard N, Arenberg DA, Bolejack V, Donington JS, Mazzone PJ, Tanoue LT, Rusch VW, Crowley J, Asamura H, Rami-Porta R, Committee I, Goldstraw P, Rami-Porta R, Asamura H, Ball D, Beer D, Beyruti R, Bolejack V, Chansky K, Crowley J, Detterbeck F, Eberhardt W, Edwards J, Galateau-Sallé F, Giroux D, Gleeson F, Groome P, Huang J, Kennedy C, Kim J, Kim Y, Kingsbury L, Kondo H, Krasnik M, Kubota K, Lerut A, Lyons G, Marino M, Marom E, van Meerbeeck J, Mitchell A, Nakano T, Nicholson A, Nowak A, Peake M, Rice T, Rosenzweig K, Ruffini E, Rusch V, Saijo N, Van Schil P, Sculier J, Shemanski L, Stratton K, Suzuki K, Tachimori Y, Thomas C, Travis W, Tsao M, Turrisi A, Vansteenkiste J, Watanabe H, Wu Y, Boards A, Baas P, Erasmus J, Hasegawa S, Inai K, Kernstine K, Kindler H, Krug L, Nackaerts K, Pass H, Rice D, Falkson C, Filosso P, Giaccone G, Kondo K, Lucchi M, Okumura M, Blackstone E, Workgroup M, Flieder D, Godoy M, Goo J, Goodman L, Jett J, de Leyn P, Marchevsky A, MacMahon H, Naidich D, Okada M, Perlman M, Powell C, van Schil P, Warth A, Institutions P, Cavaco F, Barrera E, Arca J, Lamelas I, Obrer A, Jorge R, Ball D, Bascom G, Orozco A, Castro M, Blum M, Chimondeguy D, Cvijanovic V, Defranchi S, de Olaiz Navarro B, Campuzano I, Vidueira I, Araujo E, García F, Fong K, Corral G, González S, Gilart J, Arangüena L, Barajas S, Girard P, Goksel T, Budiño M, Casaurrán G, Blanco J, Hernández J, Rodríguez H, Collantes J, Heras M, Elena J, Jakobsen E, Kostas S, Atance P, Ares A, Liao M, Losanovscky M, Lyons G, Magaroles R, De Esteban Júlvez L, Gorospe M, McCaughan B, Kennedy C, Íñiguez R, Sorribes L, Gozalo S, de Arriba C, Delgado M, Alarcón J, Cuesta J, Park J, Pass H, Fernández M, Rosenberg M, Ruffini E, Rusch V, de Cos Escuín J, Vinuesa A, Mitjans M, Strand T, Subotic D, Swisher S, Terra R, Thomas C, Tournoy K, Van Schil P, Velasquez M, Wu Y, Yokoi K. The IASLC Lung Cancer Staging Project: Summary of Proposals for Revisions of the Classification of Lung Cancers with Multiple Pulmonary Sites of Involvement in the Forthcoming Eighth Edition of the TNM Classification. Journal Of Thoracic Oncology 2016, 11: 639-650. PMID: 26940528, DOI: 10.1016/j.jtho.2016.01.024.Peer-Reviewed Original ResearchConceptsMultiple pulmonary sitesLung cancerPulmonary sitesM categoryTNM classificationSecond primary lung cancerEighth editionIASLC Lung Cancer Staging ProjectLung Cancer Staging ProjectForthcoming Eighth EditionSame histologic typePrimary lung cancerLung cancer stagingLung cancer databaseSeparate tumor nodulesArea of involvementPatterns of diseasePrognostic Factors CommitteeClinical presentationHistologic typePathologic correlatesMetastasis classificationOptimal treatmentT categoryCancer Database
2014
How many names for a rose: Inconsistent classification of multiple foci of lung cancer due to ambiguous rules
Fonseca A, Detterbeck FC. How many names for a rose: Inconsistent classification of multiple foci of lung cancer due to ambiguous rules. Lung Cancer 2014, 85: 7-11. PMID: 24768582, DOI: 10.1016/j.lungcan.2014.02.014.Peer-Reviewed Original ResearchConceptsLung cancerPulmonary fociSeparate primary cancersOutcomes of patientsComparison of outcomesDifferent histologic typesMultifocal lung cancerSuch patientsHistologic typePrimary cancerPatient groupClinical scenariosPatientsCancerMultiple fociStage classificationMarked variabilityOutcomesInconsistent classificationClinicians