2017
Performance of Serum Creatinine and Kidney Injury Biomarkers for Diagnosing Histologic Acute Tubular Injury
Moledina DG, Hall IE, Thiessen-Philbrook H, Reese PP, Weng FL, Schröppel B, Doshi MD, Wilson FP, Coca SG, Parikh CR. Performance of Serum Creatinine and Kidney Injury Biomarkers for Diagnosing Histologic Acute Tubular Injury. American Journal Of Kidney Diseases 2017, 70: 807-816. PMID: 28844586, PMCID: PMC5701867, DOI: 10.1053/j.ajkd.2017.06.031.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultArea Under CurveBiomarkersCohort StudiesCreatinineCross-Sectional StudiesFatty Acid-Binding ProteinsFemaleHepatitis A Virus Cellular Receptor 1HumansInterleukin-18Kidney TransplantationKidney TubulesLipocalin-2MaleMiddle AgedProspective StudiesROC CurveSeverity of Illness IndexTissue DonorsConceptsSevere acute tubular injuryAcute kidney injuryAcute tubular injuryTubular injurySCr concentrationNGAL concentrationsUrinary biomarkersDeceased donorsOrgan procurementMulticenter prospective cohortUrinary L-FABPUrinary NGAL concentrationsDeceased kidney donorsKidney injury biomarkersSerum creatinine concentrationPoor diagnostic performanceAKI casesAKI causesDonor hospitalizationKidney injuryProspective cohortSerum creatinineInjury biomarkersKidney biopsyIL-18Renal tubular resistance is the primary driver for loop diuretic resistance in acute heart failure
Maaten J, Rao VS, Hanberg JS, Wilson F, Bellumkonda L, Assefa M, Broughton J, D'Ambrosi J, Tang W, Damman K, Voors AA, Ellison DH, Testani JM. Renal tubular resistance is the primary driver for loop diuretic resistance in acute heart failure. European Journal Of Heart Failure 2017, 19: 1014-1022. PMID: 28105769, PMCID: PMC6231236, DOI: 10.1002/ejhf.757.Peer-Reviewed Original ResearchConceptsAcute heart failureLoop diuretic resistanceRenal tubular responseDiuretic resistanceDiuretic responseRenal tubulesAHF patientsHeart failureLoop diureticsTubular responseRenal tubular resistanceBumetanide doseEffective decongestionIntravenous bumetanidePoor outcomeUrine collectionTubular resistanceSum of defectsPatient variabilityUrea clearancePatientsCommon barriersDoseClearanceDiuretics
2016
Urine biomarkers of tubular injury do not improve on the clinical model predicting chronic kidney disease progression
Hsu CY, Xie D, Waikar SS, Bonventre JV, Zhang X, Sabbisetti V, Mifflin TE, Coresh J, Diamantidis CJ, He J, Lora CM, Miller ER, Nelson RG, Ojo AO, Rahman M, Schelling JR, Wilson FP, Kimmel PL, Feldman HI, Vasan RS, Liu KD, Investigators C, Appel L, Feldman H, Go A, He J, Kusek J, Lash J, Ojo A, Rahman M, Townsend R, Consortium C. Urine biomarkers of tubular injury do not improve on the clinical model predicting chronic kidney disease progression. Kidney International 2016, 91: 196-203. PMID: 28029431, PMCID: PMC5362331, DOI: 10.1016/j.kint.2016.09.003.Peer-Reviewed Original ResearchMeSH KeywordsAcetylglucosaminidaseAgedAlbuminuriaBiomarkersCreatinineDisease ProgressionFatty Acid-Binding ProteinsFemaleFollow-Up StudiesGlomerular Filtration RateHepatitis A Virus Cellular Receptor 1HumansKidney Failure, ChronicKidney TubulesLipocalin-2MaleMiddle AgedProportional Hazards ModelsProspective StudiesRenal Insufficiency, ChronicRisk AssessmentRisk FactorsConceptsGlomerular filtration rateUrinary albumin/creatinine ratioAlbumin/creatinine ratioKidney disease progressionTubular injury biomarkersCKD progressionInjury biomarkersFiltration rateClinical modelSerum creatinineCreatinine ratioDisease progressionProspective Chronic Renal Insufficiency Cohort StudyChronic Renal Insufficiency Cohort (CRIC) StudyIncident end-stage renal diseaseUnadjusted Cox proportional hazards modelUrinary kidney injury molecule-1Renal tubular injury biomarkersChronic kidney disease progressionKidney injury molecule-1End-stage renal diseaseNeutrophil gelatinase-associated lipocalinCox proportional hazards modelBase clinical modelInjury molecule-1