2020
A Time-Updated, Parsimonious Model to Predict AKI in Hospitalized Children
Sandokji I, Yamamoto Y, Biswas A, Arora T, Ugwuowo U, Simonov M, Saran I, Martin M, Testani JM, Mansour S, Moledina DG, Greenberg JH, Wilson FP. A Time-Updated, Parsimonious Model to Predict AKI in Hospitalized Children. Journal Of The American Society Of Nephrology 2020, 31: 1348-1357. PMID: 32381598, PMCID: PMC7269342, DOI: 10.1681/asn.2019070745.Peer-Reviewed Original ResearchConceptsExternal validation cohortValidation cohortElectronic health recordsSevere AKIClinical risk stratification toolDevelopment of AKIHealth recordsRisk stratification toolInternal validation cohortLength of stayCharacteristic curveElectronic medical recordsNeonatal AKIInpatient mortalitySecondary outcomesHospital admissionPrimary outcomeHospitalized childrenCreatinine valuesMedical recordsStudy populationAKICohortChildrenPredictive variables
2018
Development of biomarker combinations for postoperative acute kidney injury via Bayesian model selection in a multicenter cohort study
Meisner A, Kerr KF, Thiessen-Philbrook H, Wilson FP, Garg AX, Shlipak MG, Kavsak P, Whitlock RP, Coca SG, Parikh CR. Development of biomarker combinations for postoperative acute kidney injury via Bayesian model selection in a multicenter cohort study. Biomarker Research 2018, 6: 3. PMID: 29344362, PMCID: PMC5767010, DOI: 10.1186/s40364-018-0117-z.Peer-Reviewed Original ResearchCardiopulmonary bypass timeMild AKISevere AKICardiac surgeryBiomarker combinationsBypass timeKidney injurySerum creatininePostoperative acute kidney injuryB-type natriuretic peptideAcute kidney injuryBackgroundAcute kidney injuryHeart-type fatty acidMethodsThe primary endpointSerum creatinine increaseMulticenter cohort studyPlasma interleukin-6Optimism-corrected AUCPostoperative biomarkersCreatinine increaseHospital stayPrimary endpointPreoperative levelsCohort studyFrequent complication
2014
Dialysis versus Nondialysis in Patients with AKI: A Propensity-Matched Cohort Study
Wilson FP, Yang W, Machado CA, Mariani LH, Borovskiy Y, Berns JS, Feldman HI. Dialysis versus Nondialysis in Patients with AKI: A Propensity-Matched Cohort Study. Clinical Journal Of The American Society Of Nephrology 2014, 9: 673-681. PMID: 24651073, PMCID: PMC3974360, DOI: 10.2215/cjn.07630713.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultAgedBiomarkersCreatinineFemaleHospitalizationHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioPatient SelectionPennsylvaniaPropensity ScoreProportional Hazards ModelsRenal DialysisRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeConceptsInitiation of dialysisSerum creatinine concentrationCreatinine concentrationDialysis initiationDialyzed patientsSevere AKICohort studyPropensity-matched cohort studyPropensity scoreElevated creatinine levelOverall hazard ratioGreater survival benefitProportional hazards analysisAcute care hospitalsTime-varying propensity scoresPennsylvania Health SystemCause mortalityCreatinine levelsHazard ratioSurvival benefitCare hospitalDL increaseNondialyzed patientsPatient factorsLaboratory variables
2013
Sundays and Mortality in Patients with AKI
Wilson FP, Yang W, Schrauben S, Machado C, Lin JJ, Feldman HI. Sundays and Mortality in Patients with AKI. Clinical Journal Of The American Society Of Nephrology 2013, 8: 1863-1869. PMID: 23970128, PMCID: PMC3817908, DOI: 10.2215/cjn.03540413.Peer-Reviewed Original Research
2012
Predictors of Death and Dialysis in Severe AKI: The UPHS-AKI Cohort
Wilson FP, Yang W, Feldman HI. Predictors of Death and Dialysis in Severe AKI: The UPHS-AKI Cohort. Clinical Journal Of The American Society Of Nephrology 2012, 8: 527-537. PMID: 23258795, PMCID: PMC3613955, DOI: 10.2215/cjn.06450612.Peer-Reviewed Original ResearchConceptsSevere AKIC-indexIntensive care unit locationPredictors of deathEffective risk stratificationEndpoint of deathMore effective therapeutic interventionsHigh-risk subgroupsHarrell's C-indexLower overall mortalityProportional hazards modelEffective therapeutic interventionsPennsylvania Health SystemBaseline creatinineHospital AKIPressor medicationsSerum creatinineClinical factorsDerivation cohortHigher creatinineHospital admissionOverall mortalityLiver diseaseRisk stratificationValidation cohort