2018
Development of biomarker combinations for postoperative acute kidney injury via Bayesian model selection in a multicenter cohort study
Meisner A, Kerr KF, Thiessen-Philbrook H, Wilson FP, Garg AX, Shlipak MG, Kavsak P, Whitlock RP, Coca SG, Parikh CR. Development of biomarker combinations for postoperative acute kidney injury via Bayesian model selection in a multicenter cohort study. Biomarker Research 2018, 6: 3. PMID: 29344362, PMCID: PMC5767010, DOI: 10.1186/s40364-018-0117-z.Peer-Reviewed Original ResearchCardiopulmonary bypass timeMild AKISevere AKICardiac surgeryBiomarker combinationsBypass timeKidney injurySerum creatininePostoperative acute kidney injuryB-type natriuretic peptideAcute kidney injuryBackgroundAcute kidney injuryHeart-type fatty acidMethodsThe primary endpointSerum creatinine increaseMulticenter cohort studyPlasma interleukin-6Optimism-corrected AUCPostoperative biomarkersCreatinine increaseHospital stayPrimary endpointPreoperative levelsCohort studyFrequent complication
2012
Creatinine generation is reduced in patients requiring continuous venovenous hemodialysis and independently predicts mortality
Wilson FP, Sheehan JM, Mariani LH, Berns JS. Creatinine generation is reduced in patients requiring continuous venovenous hemodialysis and independently predicts mortality. Nephrology Dialysis Transplantation 2012, 27: 4088-4094. PMID: 22273668, PMCID: PMC3529547, DOI: 10.1093/ndt/gfr809.Peer-Reviewed Original ResearchConceptsAcute kidney injuryCreatinine generation rateContinuous venovenous hemodialysisSeverity of AKISerum creatinine concentrationCreatinine concentrationHospital mortalityTertiary care hospital settingSerum creatinine increaseGlomerular filtration rateLength of hospitalizationMeasures of severityAKI severityCreatinine increaseKidney injuryHospital dischargeMultivariable adjustmentSerum creatinineCohort studyMultivariable analysisPatient populationUnadjusted analysesCreatinine generationFiltration rateOncologic diagnosis