2022
Clinically adjudicated deceased donor acute kidney injury and graft outcomes
Mansour SG, Khoury N, Kodali R, Virmani S, Reese PP, Hall IE, Jia Y, Yamamoto Y, Thiessen-Philbrook HR, Obeid W, Doshi MD, Akalin E, Bromberg JS, Harhay MN, Mohan S, Muthukumar T, Singh P, Weng FL, Moledina DG, Greenberg JH, Wilson FP, Parikh CR. Clinically adjudicated deceased donor acute kidney injury and graft outcomes. PLOS ONE 2022, 17: e0264329. PMID: 35239694, PMCID: PMC8893682, DOI: 10.1371/journal.pone.0264329.Peer-Reviewed Original ResearchConceptsDonor Acute Kidney InjuryAcute kidney injuryGraft failureAKI phenotypesKidney injuryUrine biomarkersLack of associationAKI casesGraft functionHigher DGFPotential kidneyGraft outcomeDeceased donorsOrgan utilizationMCP-1YKL-40Donor StudyEGFRDGFAncillary analysisAvailable chartsBiomarkersInjuryPhenotypeAssociation
2017
Group analysis identifies differentially elevated biomarkers with distinct outcomes for advanced acute kidney injury in cardiac surgery
Lin H, Scherzer R, Philbrook HT, Coca SG, Wilson FP, Garg AX, Shlipak MG, Parikh CR. Group analysis identifies differentially elevated biomarkers with distinct outcomes for advanced acute kidney injury in cardiac surgery. Biomarkers In Medicine 2017, 11: 1091-1102. PMID: 29172665, PMCID: PMC5753615, DOI: 10.2217/bmm-2017-0060.Peer-Reviewed Original ResearchConceptsAdvanced acute kidney injuryAcute kidney injuryKidney injuryCardiac surgeryPatient groupSingle biomarkerIndividual biomarkersPostoperative biomarkersDistinct biomarker patternsNT-proBNPSecondary outcomesIL-10Clinical variablesIL-6Plasma biomarkersCK-MBRisk discriminationAbstractTextH-FABPBiomarkersSignificant differencesSurgeryBiomarker patternsInjuryOutcomesEvaluating biomarkers for prognostic enrichment of clinical trials
Kerr KF, Roth J, Zhu K, Thiessen-Philbrook H, Meisner A, Wilson FP, Coca S, Parikh CR. Evaluating biomarkers for prognostic enrichment of clinical trials. Clinical Trials 2017, 14: 629-638. PMID: 28795578, PMCID: PMC5714681, DOI: 10.1177/1740774517723588.Peer-Reviewed Original ResearchConceptsPrognostic enrichmentTrial eligibility criteriaClinical trialsEligibility criteriaTrial resultsClinical trial sample sizesOutcomes of interestTrial sample sizeTrial metricsOnly patientsBACKGROUND/Prognostic biomarkerPrognostic performanceHigh riskClinical settingScreening costsBiomarkersTrialsScreening thresholdCalendar timeTrial costsSample sizePatients