Featured Publications
Locally delivered adjuvant biofilm‐penetrating antibiotics rescue impaired endochondral fracture healing caused by MRSA infection
Cahill SV, Kwon H, Back J, Lee I, Lee S, Alder KD, Hao Z, Yu KE, Dussik CM, Kyriakides T, Lee F. Locally delivered adjuvant biofilm‐penetrating antibiotics rescue impaired endochondral fracture healing caused by MRSA infection. Journal Of Orthopaedic Research® 2021, 39: 402-414. PMID: 33336805, DOI: 10.1002/jor.24965.Peer-Reviewed Original ResearchConceptsHigh-dose rifampinFracture healingMRSA infectionMethicillin-resistant Staphylococcus aureus osteomyelitisColony-forming unitsTissue bacterial loadStaphylococcus aureus osteomyelitisReactive bone formationRadiographic union scaleEndochondral fracture healingBacterial CFU countsPoor callus formationSoft callus formationTibia scoresRifampin therapyDevastating complicationMRSA colonizationClinical efficacyInfected fracturesTibial radiographsTreatment responseMurine modelIntramedullary pinOpen fracturesO stainIntracellular Staphylococcus aureus in bone and joint infections: A mechanism of disease recurrence, inflammation, and bone and cartilage destruction
Alder KD, Lee I, Munger AM, Kwon HK, Morris MT, Cahill SV, Back J, Yu KE, Lee FY. Intracellular Staphylococcus aureus in bone and joint infections: A mechanism of disease recurrence, inflammation, and bone and cartilage destruction. Bone 2020, 141: 115568. PMID: 32745687, DOI: 10.1016/j.bone.2020.115568.Peer-Reviewed Original ResearchConceptsArticular cartilage lossJoint infectionCartilage lossStaphylococcus aureusIntracellular Staphylococcus aureusPotential combination therapyFurther studiesPotential treatment solutionAntibiotic therapyDisease recurrenceProinflammatory stateCartilage destructionMorbidity rateCombination therapyDismal outcomeMassive boneConsequence of boneHigh mortalityMedical interventionsInfectionIntracellular infectionMusculoskeletal systemDevastating afflictionFundamental cellular componentsBone
2019
Rotational Tibio-Pelvic Constrained Hip Arthroplasty: A Surgical Technique: A Case Report.
Cahill SV, Yu KE, Dussik CM, Lee FY. Rotational Tibio-Pelvic Constrained Hip Arthroplasty: A Surgical Technique: A Case Report. JBJS Case Connector 2019, 9: e0404. PMID: 31703012, DOI: 10.2106/jbjs.cc.18.00404.Peer-Reviewed Original ResearchConceptsSoft tissue infectionsVan Nes rotationplastyExtensive debridementChronic boneHip disarticulationTissue infectionsFemur resectionDebridement proceduresRecurrent infectionsCase reportRight thighEpithelioid sarcomaSurgical techniqueHip arthroplastyIncurable infectionProsthetic hipInfectionRotationplastyResectionMultiple revisionsProsthetic devicesDebridementPatientsSarcomaArthroplasty