2023
Parathyroid hormone therapy improves MRSA-infected fracture healing in a murine diabetic model
Kwon H, Cahill S, Yu K, Alder K, Dussik C, Jeong J, Back J, Lee F. Parathyroid hormone therapy improves MRSA-infected fracture healing in a murine diabetic model. Frontiers In Cellular And Infection Microbiology 2023, 13: 1230568. PMID: 37829606, PMCID: PMC10565816, DOI: 10.3389/fcimb.2023.1230568.Peer-Reviewed Original ResearchConceptsFracture healingTeriparatide treatmentType 2 diabetic mouse modelType 2 diabetes mellitus miceBone volume/total volumeMurine diabetic modelTotal mineral densityIntermittent parathyroid hormoneSystemic antibiotic therapyImpairs fracture healingPoor fracture healingAdjuvant therapeutic agentDiabetes mellitus miceDiabetic mouse modelBlood glucose levelsCombination of antibioticsRadiographic union scaleTibia fracture modelIPTH treatmentSeptic nonunionNondiabetic counterpartsT2DM miceHormone therapyAntibiotic therapyMRSA infection
2019
Bone Quality and Fracture-Healing in Type-1 and Type-2 Diabetes Mellitus.
Henderson S, Ibe I, Cahill S, Chung YH, Lee FY. Bone Quality and Fracture-Healing in Type-1 and Type-2 Diabetes Mellitus. Journal Of Bone And Joint Surgery 2019, 101: 1399-1410. PMID: 31393433, DOI: 10.2106/jbjs.18.01297.Peer-Reviewed Original ResearchConceptsType 2 diabetesPerioperative complicationsDiabetic patientsGlycemic controlBone healthType 1Type 2 diabetes mellitusNormal bone mineral densityPerioperative glycemic controlNon-diabetic patientsEarly bone lossSurgical site infectionAppropriate glycemic controlUnion of fractureRisk of fractureBone mineral densityType 1 diabetesAntiresorptive therapyOperative interventionDiabetes mellitusSclerostin antibodySite infectionMedical managementParathyroid hormonePostoperative management