Featured Publications
Percutaneous Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Pain and Ambulatory Function in Periacetabular Osteolytic Malignancies.
Dussik C, Toombs C, Alder K, Yu K, Berson E, Ibe I, Li F, Lindskog D, Friedlaender G, Latich I, Lee F. Percutaneous Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Pain and Ambulatory Function in Periacetabular Osteolytic Malignancies. Radiology 2023, 307: e221401. PMID: 36916888, DOI: 10.1148/radiol.221401.Peer-Reviewed Original ResearchConceptsOsteolytic neoplasmAmbulatory functionInternal fixationEastern Cooperative Oncology Group scoreIndex scoreConversion hip arthroplastyRetrospective observational studySurgical site infectionKaplan-Meier analysisLong-term painQuality of lifeLong-term improvementWilcoxon signed-rank testNonambulatory patientsSecondary outcomesPrimary outcomeSite infectionOncologic careECOG scorePercutaneous ablationPeriacetabular metastasisProtrusio acetabuliFunctional improvementSigned-rank testClinical data
2020
Minimally Invasive Image-Guided Ablation, Osteoplasty, Reinforcement, and Internal Fixation (AORIF) for Osteolytic Lesions in the Pelvis and Periarticular Regions of Weight-Bearing Bones
Lee FY, Latich I, Toombs C, Mungur A, Conway D, Alder K, Ibe I, Lindskog D, Friedlaender G. Minimally Invasive Image-Guided Ablation, Osteoplasty, Reinforcement, and Internal Fixation (AORIF) for Osteolytic Lesions in the Pelvis and Periarticular Regions of Weight-Bearing Bones. Journal Of Vascular And Interventional Radiology 2020, 31: 649-658.e1. PMID: 32139256, DOI: 10.1016/j.jvir.2019.11.029.Peer-Reviewed Original ResearchMeSH KeywordsAblation TechniquesAdultAgedAged, 80 and overBone CementsBone NeoplasmsBone RemodelingBone ScrewsCalcaneusCementoplastyFemaleFemoral NeoplasmsFemurFracture Fixation, InternalHumansMaleMiddle AgedOsteolysisPelvic BonesPostoperative ComplicationsProspective StudiesRecovery of FunctionTibiaTime FactorsTreatment OutcomeWeight-BearingConceptsOsteolytic lesionsInternal fixationVisual analog scale pain scoreMusculoskeletal Tumor Society scoreProspective clinical cohort studyFunctional ambulation scoreOsteolytic skeletal lesionsPainful osteolytic lesionsScale pain scoresClinical cohort studyInvasive percutaneous approachWeight-bearing boneInternal fixation screwsBalloon osteoplastyPain scoresCohort studyProphylactic stabilizationSevere painSociety ScoreConsecutive patientsSurgical treatmentEarly outcomesTreatment optionsPercutaneous approachFunctional improvement
2015
Optimal internal fixation of anatomically shaped synthetic bone grafts for massive segmental defects of long bones
Vorys GC, Bai H, Chandhanayingyong C, Lee CH, Compton JT, Caldwell JM, Gardner TR, Mao JJ, Lee FY. Optimal internal fixation of anatomically shaped synthetic bone grafts for massive segmental defects of long bones. Clinical Biomechanics 2015, 30: 1114-1118. PMID: 26386637, PMCID: PMC9004608, DOI: 10.1016/j.clinbiomech.2015.08.016.Peer-Reviewed Original ResearchConceptsTorsional stiffnessHydroxyapatite composite scaffoldsCyclic torsional testsNon-locking fixationMassive segmental defectsTissue engineering strategiesLarge segmental bone defectsComposite scaffoldsLoading cyclesTorque controlSynthetic bone graftAxial stiffnessAngular rotationAxial compressionTorsional testsNon-destructive mannerGeometry representativeOptimal screw fixationSegmental bone defectsSuch scaffoldsTorque levelsStiffnessBiomechanical testingHuman tibiaEngineering strategies
2006
Stromal cell‐derived factor 1 (SDF‐1, CXCL12) is increased in subacromial bursitis and downregulated by steroid and nonsteroidal anti‐inflammatory agents
Kim Y, Bigliani LU, Fujisawa M, Murakami K, Chang S, Lee H, Lee FY, Blaine TA. Stromal cell‐derived factor 1 (SDF‐1, CXCL12) is increased in subacromial bursitis and downregulated by steroid and nonsteroidal anti‐inflammatory agents. Journal Of Orthopaedic Research® 2006, 24: 1756-1764. PMID: 16779827, DOI: 10.1002/jor.20197.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalBursa, SynovialBursitisCells, CulturedChemokine CXCL12Chemokines, CXCCyclooxygenase 2 InhibitorsDexamethasoneDown-RegulationEnzyme-Linked Immunosorbent AssayHumansIn Vitro TechniquesMiddle AgedOligonucleotide Array Sequence AnalysisReverse Transcriptase Polymerase Chain ReactionRNA, MessengerRotator CuffTendinopathyConceptsReal-time reverse transcription-polymerase chain reactionSDF-1 proteinEnzyme-linked immunosorbent assayCOX-2 inhibitorsStromal cell-derived factor-1Cell-derived factor-1SDF-1 expressionSubacromial bursaSDF-1Subacromial bursitisReal-time RT-PCRBursal cellsBursal tissueNormal bone marrow stromal cellsNonsteroidal anti-inflammatory agentsSDF-1 expression levelsAnti-inflammatory medicationsUse of steroidsAnti-inflammatory agentsFactor 1Reverse transcription-polymerase chain reactionSubacromial bursal tissueRotator cuff diseaseTranscription-polymerase chain reactionSubacromial bursa tissue
1999
Chondrosarcoma of bone: an assessment of outcome.
Lee FY, Mankin HJ, Fondren G, Gebhardt MC, Springfield DS, Rosenberg AE, Jennings LC. Chondrosarcoma of bone: an assessment of outcome. Journal Of Bone And Joint Surgery 1999, 81: 326-38. PMID: 10199270, DOI: 10.2106/00004623-199903000-00004.Peer-Reviewed Original ResearchConceptsGrade 3 lesionsIntralesional resectionLocal recurrenceHistological gradePostoperative adjuvant radiationLimb-sparing proceduresPredictor of metastasisGroup of patientsHigh-grade lesionsLow-grade tumorsPredictors of outcomeHigh-grade tumorsAssessment of outcomesAdjuvant radiationPathological fracturesRecurrent diseasePulmonary metastasesDistant metastasisAdjunctive chemotherapyMarginal resectionMean ageMean durationPelvic locationPrevalent siteGrade 3
1998
Reconstruction Of The Shoulder Joint Using An Acetabular Allograft
Lee FY, Hornicek FJ, Hazan EJ, Kloen P, Wolfe MA, Mankin HJ. Reconstruction Of The Shoulder Joint Using An Acetabular Allograft. Clinical Orthopaedics And Related Research® 1998, 357: 120-121. PMID: 9917707, DOI: 10.1097/00003086-199812000-00015.Peer-Reviewed Original ResearchConceptsShoulder jointAcetabular allograftWide resectionMusculoskeletal Tumor Society systemStable shoulder jointAggressive lesionsOsteoarticular allograftsAggressive tumorsCosmetic resultsFunctional resultsSurgical reconstructionAllograftsSecure reattachmentPatientsSoft tissueResectionCenter of motionSelect groupScapulaTumorsGlenoid regionJointsLesions