2017
Tendon stem/progenitor cells regulate inflammation in tendon healing via JNK and STAT3 signaling
Tarafder S, Chen E, Jun Y, Kao K, Sim KH, Back J, Lee FY, Lee CH. Tendon stem/progenitor cells regulate inflammation in tendon healing via JNK and STAT3 signaling. The FASEB Journal 2017, 31: 3991-3998. PMID: 28533328, PMCID: PMC5572690, DOI: 10.1096/fj.201700071r.Peer-Reviewed Original ResearchConceptsConnective tissue growth factorTendon stem/progenitor cellsIL-10 expressionStem/progenitor cellsIL-10TIMP-3 expressionTendon healingIL-1βProgenitor cellsTendon cellsElevated IL-10 expressionAnti-inflammatory IL-10Number of iNOSRat patellar tendonAnti-inflammatory roleAcute tendon injuryIL-6 expressionRegulation of inflammationTissue growth factorMMP-3 expressionNumber of CD146Improved tendon healingDifferent anatomic locationsWestern blot analysisPromising regenerative potential
2015
Harnessing endogenous stem/progenitor cells for tendon regeneration
Lee CH, Lee FY, Tarafder S, Kao K, Jun Y, Yang G, Mao JJ. Harnessing endogenous stem/progenitor cells for tendon regeneration. Journal Of Clinical Investigation 2015, 125: 2690-2701. PMID: 26053662, PMCID: PMC4563693, DOI: 10.1172/jci81589.Peer-Reviewed Original ResearchMeSH KeywordsAdult Stem CellsAnimalsCD146 AntigenCell DifferentiationCell ProliferationColony-Forming Units AssayConnective Tissue Growth FactorFocal Adhesion Kinase 1MAP Kinase Signaling SystemMultipotent Stem CellsRatsRats, Sprague-DawleyRegenerationTendon InjuriesTendonsTissue EngineeringWound HealingConceptsStem/progenitor cellsEndogenous stem/progenitor cellsProgenitor cellsCell transplantationTendon regenerationStem cell markers CD146Stem cell-based strategiesFAK/ERK1/2Cell-based strategiesRat modelTendon healingFunctional restorationNormal levelsMultilineage differentiation abilityClonogenic capacityCD146Tendon cellsSiRNA knockdownTransplantationVivo manipulation
2009
Improving bone density at the rotator cuff footprint increases supraspinatus tendon failure stress in a rat model
Cadet ER, Vorys GC, Rahman R, Park S, Gardner TR, Lee FY, Levine WN, Bigliani LU, Ahmad CS. Improving bone density at the rotator cuff footprint increases supraspinatus tendon failure stress in a rat model. Journal Of Orthopaedic Research® 2009, 28: 308-314. PMID: 19743506, DOI: 10.1002/jor.20972.Peer-Reviewed Original ResearchConceptsBone densityRotator cuff footprintOVX groupRat modelSupraspinatus tendonCuff footprintQuantitative micro-computed tomographyMonths of ageBisphosphonate treatmentOVX ratsBilateral ovariectomyProximal humerusDawley ratsAdditional ratsOVXRatsTendonOvariectomyMicro-computed tomographyTreatmentGroupBisphosphonatesSpragueHumerusMonths